Did you know that the vast majority of Americans have lived within a few hundred yards of an illicit
drug lab at some point in their lives?
Did you know that the vast majority of Americans have lived within a few hundred yards of an illicit
drug lab at some point in their lives?
Not exact matches
The US Food and
Drug Administration issued a «preliminary finding» that the genetically modified insects, produced by Oxitec
at its
labs in Oxford, England, and shipped as eggs to Florida, would have essentially «no significant impact» on human health, animal health, or the ecosystem.
Armed with new methods for detecting EPO, Graham Trout and his colleagues
at Australia's Sports
Drug Testing
lab have Olympic cheaters in their crosshairs
burned their home in 98 by meth
lab & daughter now goin thru trial — molested & abused
at 4 & 5 — still bein left with single, unstable, alcoholics &
drug abusers — no one including cps cares.
While there are
at - home
drug test kits available for steroid use, they are expensive and have to be sent to a
lab to get your results.
That's why Science recognized the idea of «treatment as prevention» as its scientific breakthrough of the year, crediting the
lab of infectious diseases researcher Myron Cohen, a physician - scientist
at the University of North Carolina School (UNC) of Medicine in Chapel Hill, with discovering and investigating one of the most promising antiretroviral
drugs, HPTN 052.
This juncture between basic research and the
drug development process first began to interest Conley when she was still a postdoc
at Michigan, where she had an «amazing experience» in a «world - renowned research
lab.»
While clinicians have been looking
at different ways to prevent higher blood glucose levels by prescribing anti-diabetic
drugs, Wright said his
lab is interested in exercise physiology and trying to figure out how exercise can improve glucose homeostasis.
«It's particularly encouraging in this study that even
at relatively low concentrations the liver
drug still had an effect on Parkinson's cells grown in the
lab.
Doug Mahoney's
lab at the University of Calgary recently discovered an immunotherapy that uses existing cancer
drugs in a whole new way.
Roughly 1200 of these are research
labs, which are often housed
at major academic centers or run by government agencies themselves, including the National Institutes of Health, the Food and
Drug Administration, and the Centers for Disease Control and Prevention.
«The ongoing line of work with this
drug is an excellent example of the bench getting even closer to the bedside — our
lab work with the
drug in patient - derived xenograft models of disease makes possible the clinical trials taking place
at the University of Colorado Hospital next door,» Jimeno says.
«Having the structure of the full - length Zika NS1 provides new information that can help guide the design of a potential vaccine or antiviral
drugs,» said senior author Janet Smith, director of the Center for Structural Biology
at the U-M Life Sciences Institute, where her
lab is located, and professor of biological chemistry
at the U-M Medical School.
According to U.S. and European records, another one of the
drugs approved based on research
at Cetero's troubled Houston
lab was a chemotherapy
drug known as Temodar for Injection.
In
lab experiments using tissue samples cultured from cystic fibrosis patients, scientists
at the UNC School of Medicine and the UNC Marsico Lung Institute have shown that a new CF
drug counteracts the intended beneficial molecular effect of another CF
drug.
«We Should Have Been Told» Cross-checking U.S. and European public records, including regulatory filings, scientific studies and civil lawsuits, ProPublica was able to identify a few of the
drugs that are on the U.S. market because of tests performed
at Cetero's Houston
lab (see chart.)
Dr Dusko Ilic, leader of the team
at King's College London, says: «Our new method can be used to grow much greater quantities of
lab - grown human epidermal equivalents, and thus could be scaled up for commercial testing of
drugs and cosmetics.
Houses formerly used as meth
labs, called meth houses, put their residents
at risk of serious health consequences, says Stan Smith, a doctoral student
at the University of California, Los Angeles, and director of the
Drug Endangered Children Task Force, a division of the California
Drug Enforcement Agency.
However, CiRA researchers from Professor Junya Tochuchda's
lab instead looked
at molecules related with inflammation, finding Activin - A as a candidate
drug target.
During her final two years
at the agency, she had directed the
Lab of Antiviral
Drug Mechanisms, where she studied therapies for AIDS as well as one of its associated cancers, Kaposi's sarcoma.
Realizing they might have a potentially effective
drug on their hands, Bogyo and his colleagues brought in Sonnenburg, whose
lab is adept
at using mouse models of C. difficile infection.
They tested these
drugs one
at a time for lethal interaction with 112 different tumor - suppressor gene mutations in human cancer cells growing in the
lab.
The model, described in a study published this week in Biomicrofluidics, from AIP Publishing, will enable researchers to study potential disease causes and test new
drugs to treat IBD, said study author Amy Dawson, a postdoctoral researcher in the
lab of John Greenman
at the University of Hull, U.K..
Studying how genes affect different
drugs manufactured by different companies gives Poirier greater influence on future
drug development, he feels, which would not be possible if he was employed
at any one pharmaceutical research
lab.
Using an XPS instrument
at the synchrotron
lab MAX IV in Sweden, they found that the antibacterial silver coating actually breaks down the
drugs.
Detecting explosives and
drugs will not be easy, warns Rachel Cunningham of the innovation
lab at Thames Water, which manages London's sewers.
The Food and
Drug Administration approved the trial in January 2009 but put it on hold last September because of safety concerns after
lab animals injected with stem cells developed small cysts
at the injury site.
«Essentially, we took a step back and said instead of creating yet another cocktail of multiple
drugs to stop the different mechanisms of HIV, we thought we could design one that hit multiple targets
at once,» says Anthony Prosser, a graduate student in Liotta's
lab.
If we can use coconut oil as a safe, dietary alternative, we could decrease the amount of antifungal
drugs used, reserving antifungal
drugs for critical situations,» said first author Kearney Gunsalus, Ph.D., an Institutional Research and Academic Career Development (IRACDA) postdoctoral fellow
at the Sackler School in Kumamoto's
lab.
«
Drugs of abuse target the pathways of the pleasure centers very effectively,» said first author Gabriel Bossé, Ph.D., a postdoctoral researcher in Randall Peterson's
lab at U of U Health.
The couple, cancer biologists Renata Pasqualini and Wadih Arap, who run a
lab together
at M. D. Anderson Cancer Center in Houston, Texas, has a unique way of thinking about
drug development.
«We have bioengineered micro-scale heart tissues with a method that can easily be reproduced, which will enable scientists in stem cell biology and the
drug industry to study heart cells in their proper context,» said first author Nathaniel Huebsch, PhD, a postdoctoral fellow in the Conklin
lab at Gladstone.
In the
lab of Nir Barzilai, director of the Institute for Aging Research
at the Albert Einstein College of Medicine, Francine Einstein (not a descendant) has given an experimental
drug to 30 rats while shining a light on their visceral fat.
At the same time, new
drugs have been slow to emerge from research
labs, even after Pfizer's efforts to beef up its pipeline following a takeover of Wyeth in 2009.
The physiologist and her team
at Michigan State University (MSU) in East Lansing were testing how a certain
drug affects bone density, and they found that treated
lab mice lost bone compared with controls.
Almost every animal behavior studied in the
lab, from the effectiveness of experimental
drugs to the ability of monkeys to do math, is affected by stress, notes Paul Flecknell, a veterinary anesthesiologist
at Newcastle University in the United Kingdom who researches ways to alleviate pain in animals.
«Our research adds weight to the idea that effective antifungal
drugs can target even those mitochondrial proteins that are highly conserved in humans and fungi, and that this could be a way to make a broad spectrum antifungal combination therapy that would be less susceptible to resistance,» says Benjamin Vincent, a former graduate student in Whitehead Member Susan Lindquist's
lab who is now a scientist
at Yumanity Therapeutics.
Back in the
lab, Vaquer, along with Elisabet Cuyás, a biochemistry Ph.D. student
at IMIM, will determine how well the transporters did their job of storing the
drug inside the vesicles, compared with a control experiment on Earth.
Vaquer designed experiments to test the behavior of
drugs in microgravity during his spare time, while he was working in the
lab of pharmacologist Rafael de la Torre
at IMIM, focusing on a family of membrane proteins called ABC transporters.
Now a team of researchers, led by a biomedical scientist
at the University of California, Riverside, reports in this week's issue of the Proceedings of the National Academy of Sciences that it has identified just such a
drug in the
lab: indazole chloride (Ind - Cl).
An oral
drug used to treat an illness unrelated to HIV eradicated infectious HIV - producing cells in
lab cultures while sparing uninfected cells — and suppressed the virus in patients during treatment and for
at least eight weeks after the
drug was stopped, according to results of a clinical pilot trial and researchers
at Rutgers University and Dartmouth College.
In addition, a study published last year found that administering an opioid blocker decreased people's feelings of social connectedness — both when they were in the
lab receiving e-mails of support from close friends or relatives and when they were
at home during the four days they took the
drug — compared with when they took a placebo.
The molecular graphics software called Chimera, written and supported by a team of scientists in Tom Ferrin's
lab at the University of California, San Francisco (UCSF), has been cited over 7000 times and helps biologists and
drug developers visualize molecules and biological structures in 3D
at various resolutions.
Dr. Levin's
lab is investigating a new class of
drugs that are highly effective
at keeping RGCs alive when the optic nerve is damaged by glaucoma.
Following that he moved back to the United States to join the Neuroscience Discovery department
at Amgen in San Francisco, where he applied his wet
lab (molecular and cellular neurobiology) and dry
lab (human genetics and integrative genomics) expertise to
drug hunting for AD.
«In our
lab, we investigate the brain mechanisms behind
drug addiction — a common and devastating disease with limited treatment options,» explained Christopher Cowan, PhD, director of the Integrative Neurobiology Laboratory
at McLean and an associate professor of psychiatry
at Harvard Medical School.
Scientists
at the Bar Harbor - based MDI Biological Laboratory have been awarded a patent — the first for the
lab — for MSI - 1436, a potential new heart disease
drug that stimulates the repair and regeneration of heart tissue damaged by injuries and heart attacks.
«The right
drug at the right dose, taken for the right duration, is life - saving,» says Alison Halpin, a molecular epidemiologist
at the CDC whose
lab produced the study.
He joined the
lab of Stephen Fesik, who is now
at Vanderbilt but
at the time was developing structure - activity relationship (SAR) by NMR, an approach to
drug discovery using NMR.