Sentences with phrase «drug library screening»

The team plans to accomplish this goal by expanding whole genome or exome sequencing for patients, using patient - derived cells to discover new disease mechanisms, and personalized drug library screening.

Not exact matches

«The next step is screening the Takeda libraries to find a similar drug that doesn't affect the human proteasome.

When researchers screened a library of more than 200 drugs and related compounds for activity against embryonal subtype tumor cells from three patients, the most promising results involved drugs that increased oxidative stress in tumor cells.

Using a robotics - based screening approach, researchers screened a library of 1,192 FDA - approved drugs for any that suppressed tumors in the fly and identified several that improved overall survival.

Companies in the partnership supply compound libraries and drug discovery expertise to the effort, while academic partners contribute knowledge about the disease and facilities for screens and assays.

As part of drug discovery, one of the earlier stages is you take a huge library of chemical compounds and you screen them with an assay for malaria or TB and you see if that chemical compound kills the parasite or bacteria.

«It will allow us to screen libraries of drug compounds relatively quickly.

Specifically, the research team used a miniaturized, high - speed technology to screen through sample libraries of 2,816 compounds already approved by the US Food and Drug Administration for other uses.

«After screening a natural compound library, we developed an unbiased look at combinations of nutrients that have a better effect on prostate cancer than existing drugs,» says corresponding author Stefano Tiziani, assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at UT Austin.

Robotized «high - throughput screens» like this are a growing trend in drug development as they can work through massive libraries of candidate drugs quickly and accurately in a day, as opposed to the months required by manual methods.

Seeking to exploit this weakness and develop a new class of antifungals, an international group of researchers screened a synthetic drug library for compounds that target the synthesis of fungal but not mammalian GlcCer.

The process of drug discovery has been dominated in recent years by the screening of large libraries of structurally diverse small molecules for effects on target proteins associated with disease.

We are going to screen a larger library of chemicals to identify molecules that either boost or weaken NMD, which should help develop better and more targeted drugs for treating ALS, muscular dystrophy and cystic fibrosis.»

It has assembled an extensive library of commercially available compounds and natural products that can be screened in seconds using its proprietary Avalanche tool to jumpstart its drug discovery programs.

The facility maintains a small molecule library of ~ 100,000 drug - like small molecules for high - throughput screening and provides access to liquid handling robotics and a multilabel plate reader.

UniChem supports the integration of high - throughput screening data on small molecules with chemical libraries and chemical resources for drug discovery and optimization.

The collaboration is based on expanding Pelago's CETSA technology capabilities and will enable screening of large chemical libraries for identification of novel chemical leads with high drug potential.

Screen novel chemical compound libraries to identify effective drugs to treat active disease.

The self - renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells...), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.

Researchers screened a comprehensive library of approved drugs for anti-HCV activity and found a common over-the-counter allergy drug that lowered HCV levels in infected mice.

Used in experiments to understand biological processes and diseases and as part of the initial drug - discovery process, Tocris life science reagents include receptor ligands, ion channel modulators, enzyme inhibitors, caged compounds, fluorescent probes, and screening libraries.

His previous work at IDRI has included investigations into the physiology of the M.tuberculosis (Mtb) cell wall, the development of an overexpression library for high throughput target identification, and the development of target based high throughput screens for potential drug candidates against Mtb.

After developing and optimizing assays in - house, Gladstone scientists can transfer these assays to the SMDC or other external facilities to perform high - throughput screening with large compound libraries to identify potential drugs that may lead to therapies.

Phenotypic screening of small molecule libraries using iPSC - based models to identify novel drug candidates and disease mechanisms.

Targeting intracellular human thymidylate synthase in live cells, their pilot screen identified all drugs within the library known to act on this enzyme.

Towards that goal, the Foundation invested heavily in essential drug discovery assets like animal models and in vitro systems to screen existing drugs and compound libraries.

The team screened a small molecule compound library and identify a drug, which they call CLP257.