Sentences with phrase «drug molecules»

The researchers made their candidate drug molecules from three chemical sections, which can be thought of as «heads», «bodies» and «tails».

That connection creates a path for drug molecules to exit the cell.

Different drug molecules make it possible to affect the function of these receptors and, consequently, to prevent cell activation and mediator release.

The pharmaceutical industry is research and development driven, given that company growth and viability are dependent on the discovery of new drug molecules.

Much research is trying to design drug molecules able to cross such barriers, which can act as very specific filters.

If drug molecules are present in the mixture, they also become incorporated into the chains.

For example, a right - handed drug molecule may work, while the left - handed version of the same medicine may not.

They train the immune system to recognize drug molecules as foreign bodies and attack them.

With this knowledge, computer models can measure millions of potential drug molecules against the tau protein, giving immediate clues to suggest which should be tested further.

c) We design and synthesize analogues of drug molecules.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

The aim of the GPCR DOCK competition is to evaluate the accuracy of 3D structural models of GPCRs and their interactions with drug molecules.

Many of the options for working around this problem, such as encapsulating drug molecules in a protective sheath, are not practical for something that is intended to get into the tiny spaces of the extracellular matrix.

They then tested the effect of a second drug molecule called misoprostol, which also interacts with EP4, and showed that misoprostol also has the ability to combine with TKI and significantly reduce the number of leukemia stem cells.

When these nucleotide pathways are blocked by drug molecules, cancer cell growth can be halted and cell death can be triggered.

The Johns Hopkins team used a microshell made of a sugar - based polymer called cyclodextrin to protect the 3BrPA drug molecules from disintegrating early and to guard healthy tissue from the drug's toxic effects, such as weight loss, hypothermia and lethal hypoglycemic shock.

The new study builds on a technique developed in 2013 by Sleiman's research group to make nanoscale «cages» from strands of DNA, and stuff them with lipid - like polymer chains that fold together into a ball - shaped particle that can contain cargo such as drug molecules.

When Amaro added virtual drug molecules into her models, the compounds lodged in that cleft, stabilizing p53 just enough to allow it to resume its normal functions.

When drug molecules cross this barrier, certain maternal side effects (to be discussed with each medication, domperidone and metoclopramide, listing below) can occur.

However, protein molecules are much larger than most drug molecules, and synthesizing them is a «laborious, one - at - a-time» process, says Romesberg.

Filling thousands of tiny wells on lab plates with zebrafish larvae and dousing them with candidate drug molecules offers the best of both worlds — high - throughput screening in a living system.

A team led by Matthew Campbell at Trinity College in Dublin, Ireland, has now restored the vision of mice by temporarily weakening this barrier, to let drug molecules injected into the blood slip through.

Yet case documents submitted by Cao's attorneys claim that the trade secrets he allegedly stole had all appeared in published papers years earlier, and that the information did not include drug molecules, formulae, or data owned by Eli Lilly.

This research demonstrates why in certain cases we may need drug molecules to be smaller to work effectively,» said Simon Chell, from GSK's Biopharm R&D team.

«This is the first drug molecule that can regulate memory loss by directly blocking ions from leaking through nerve cell membranes,» said Ratnesh Lal, a professor of bioengineering at the University of California San Diego and co-senior author of the study.

A small piece (lower left) of a larger drug molecule (top left) is enough to distract bacterial defenses and allow the larger molecule to remain inside the bacterium.

«A rising peptide: Supercomputing helps scientists come closer to tailoring drug molecules.»

Researchers at University of California San Diego School of Medicine have shown that ozanimod (RPC1063), a novel drug molecule, is moderately effective in the treatment of ulcerative colitis.

To harness this system for the destruction of cancer proteins, Bradner's team designed a chemical adapter that attaches to a targeted drug molecule.

«We're very excited that this chemical technology may offer a way to improve many cancer drug molecules, and of course this strategy has implications beyond cancer for the treatment of other life - threatening diseases,» Bradner said.

«If we could find drug molecules that break the protein links between the knobs and the cytoskeleton, we could soften it.»

This result suggests that an IPN made from the material with the smoother interface may be the better of the two for transporting drug molecules.

Table 1 describes the main differences between biosimilar and generic drug molecules.

MIT's new nanoparticle carries three cancer - fighting drug molecules — doxorubicin is red, the small green particles are camptothecin, and the larger green core contains cisplatin (Image: Jeremiah Johnson)

Küster's research involves studying interactions between drug molecules and protein populations in cells.

Nanotechnology could be used to reformulate drug molecules which were too toxic to be delivered in a free form, said Grodzinski.

The uniqueness of the new technology from the Institute of Bioengineering and Nanotechnology (IBN) lies in the design of a special biodegradable carrier (cationic core - shell nanoparticle), which can enclose drug molecules and allow therapeutic nucleic acids to bind onto it.

Pharmaceutical companies capitalize on this property by mixing or chemically binding drug molecules to propylene glycol to increase the drug absorption rate (source).

So Dokholyan and colleagues are looking for potential drug molecules that can stabilize the dimers.

«Together, our findings indicate that these molecular regulators, TRIP - Br2 and GATA3, could be viable targets for small drug molecules that could serve as potential therapeutic agents against obesity,» Liew said.

The ProVision 100 is a computer system with software which converts data such as simulations of drug molecules or architects» designs from a two - dimensional format into three dimensions.

This test revealed 121 lysines in 113 proteins that were clearly targetable with small molecules, and thus are in principle targetable with candidate drug molecules.

That finding enabled researchers to identify, on a molecular level, the target of action for drug molecules by using rhodium - based inorganic complexes that recognize specific folds in a protein chain and catalyze minute changes in those sequences, creating a «tag» for later analysis.

Labs around the world have tried for years to obtain detailed images of human GPCRs because the precise, three - dimensional arrangement of a protein's atoms provides important details about how a protein interacts with its natural partner molecules in the body or with drug molecules.

Double - stranded RNA molecules have been produced through chemical synthesis, both as drug molecules and for research purposes, but such production methods are inefficient and expensive for plant protection,» Poranen states.

Given the advance in measurement techniques developed by the Cambridge and Copenhagen teams, drug molecules that were previously discarded at the pre-clinical stage can now be tested to determine whether they can be brought to the market in a stable glass form that overcomes the solubility limitations of the crystal form.

Researchers at the University of Illinois at Chicago have now identified a small drug molecule that can clear the HSV - 1 infection in the cells of the cornea — the clear outer layer of the eyeball — and works completely differently than the currently - available drugs, making it a promising potential option for patients who have developed resistance.

Dr Baker explained: «Our work has implications not only for understanding the basic science of protein folding and stability, but also for guiding the design and engineering of new proteins and drug molecules.»