Two new phase III clinical trials investigating the efficacy and safety of bitopertin, a glycine uptake inhibitor considered to be a promising new add - on therapy for treating negative symptoms in schizophrenia, failed to show a benefit of
the drug over placebo.
Not exact matches
The study of more than 600 smokers compared three different doses of the
drug and a
placebo over seven weeks.
According to a more recent study, the
drug could also help nondiabetic individuals lose weight as well: Subjects who received the
drug reported losing three times more weight
over a six - month period than those who received a
placebo.
But his research
over the years has soured him on the
drugs, suggesting they work only marginally better in the average patient than a
placebo pill.
Nevertheless, many studies suggest that antidepressant
drugs do have an edge
over placebos.
«
Drug that treats psoriasis also reduces aortic vascular inflammation: Randomized trial shows 19 percent improvement
over placebo group.»
Some patients on the lower dose of the
drug saw some improvements on a cognitive test
over those who got the
placebo, but the small differences could have been due to chance.
However, if SSRIs had indeed acted merely by means of a
placebo effect, these
drugs should not outperform actual
placebo in clinical trials where patients have been treated with an SSRI or with ineffective
placebo pills, and where neither the physician nor the patient knows which treatment the patient has been given until the study is
over.
Lloyd - Jones's editorial is based on a large new study published in the journal that looked at adults, ages 50 to 80, with cardiovascular disease who took extended - release niacin (vitamin B3) and laropiprant (a
drug that reduces face flushing caused by high doses of niacin) to see if it reduced heart attack and stroke compared to a
placebo over four years.
To determine how the
drug works in the human brain, Mantzoros and colleagues observed 48 obese men and women — half taking the
drug, half taking a
placebo —
over the course of a four - week experiment.
In separate studies, patients who took either Requip or Mirapex were more likely to feel improvement
over a 12 - week period than those who took
placebos; both
drugs have also been shown to be safe and effective for up to nine months.
It's the
placebo version of the glorious
drug that Warner Bros concocted with 2014's «Godzilla,» the majesty and grace of which the studio has been trying — and failing — to replicate across a half - dozen monster movies
over the last four years.
The SPIN was responsive to change in symptoms
over time and reflected different responses to active
drugs v.
placebo.