Sentences with phrase «drug pharmacokinetics»

The Intestine Chip therefore may be useful as a research tool for applications where normal intestinal function is crucial, including studies of metabolism, nutrition, infection, and drug pharmacokinetics, as well as personalized medicine.

These results suggest a huge variety of genes showing sex dimorphism in hepatic genes, which might influence drug pharmacokinetics in a sex - specific way.

Not exact matches

Although new synthetic drugs are closely evaluated for high specificity, high efficacy, low toxicity, and good pharmacokinetics, little attention is paid to the possibility that the chemically synthesized drugs may eventually be discharged from the human body into the environment in their original and / or metabolized forms.

Although the small company I worked for did not conduct animal testing on site, my work in drug discovery and providing analytical support to pharmacology directly linked me to the pharmacokinetic and toxicology screening tests.

In simple terms, pharmacokinetics, PK, measures what the body does to the drug, while pharmacodynamics, PD, measures what the drug does to the body.

Butler advises graduate students interested in industry to do two things: complete an internship at a company and make sure that they attend critical conferences related to drug metabolism and pharmacokinetics — such as the International Society for the Study of Xenobiotics.

«Based on the variability of pharmacokinetic parameters and drug clearance, the two Vancomycin nomograms developed to predict therapeutic Vancomycin concentrations in healthy adults did not accurately estimate dosage regimens in older children regardless of weight or age, and therefore should not be used to aid empiric dosing,» said Dr. Jessica Gillon.

About a year ago, she joined FDA, where she reviews pharmacokinetics for neuropharmacologic drugs.

«We know that changes in the pharmacokinetics of a drug are important because the faster a drug of abuse reaches your brain, the higher the potential for addiction,» Pepino explains.

The investigators are currently designing a study to correlate pharmacokinetics, the time course of drug metabolism, with genotype.

«Perhaps giving a person the right dose, at just the right time, of a drug with just the right pharmacokinetic properties so its effect will wear off at the right time would work a lot better than bombarding the brain with benzodiazepines, such as Valium, that knock out the entire brain.»

The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.

Establish infrastructure to test repurposed drugs in cell culture and animal models for potency, pharmacokinetic (PK), and pharmacodynamic (PD) studies.

The department includes the licensed Clinical Pharmacokinetics and Therapeutic Drug Monitoring Laboratory for St. Jude, as well as the Cancer Center's Pharmacokinetics Shared Resource.

Well - characterized drugs may come with detailed knowledge of their pharmacodynamics, pharmacokinetics and side effects as well as with established regimens for clinical applications.

On the other hand, we design drug conjugates to improve their pharmacokinetic profile and therapeutic efficacy.

In conclusion, anthelminthics poorly fulfill the preconditions of a specific mode of anticancer action and availability of pharmacokinetic and pharmacodynamic data for a favorable repurposing as anticancer drugs.

Furthermore, the drug itself is distributed differently within the extracellular matrix of the tumor and the lung parenchyma, where several and different parameters influence the pharmacokinetics.

Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA - 824 with concomitant lopinavir - ritonavir, efavirenz, or rifampin.

Studies determining Absorption, Distribution, Metabolism and Excretion (ADME) patterns in laboratory animals and humans are an integral part of the Drug Metabolism and Pharmacokinetics (DMPK) services provided by QPS.

Now, with the team's newly engineered human kidney glomerulus - on - a-chip, researchers also can get in vitro access to the kidney's core filtration mechanisms that are critical for drug clearance and pharmacokinetics, in addition to studying human podocytes at work.

The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.

Dr. Lukas» research interests are the neurobiological basis of drug and alcohol addiction, including pharmacokinetics, polydrug abuse, sex differences, complementary / alternative medicine, and medication development.

Edward Bullmore, UK Robert Dow, UK Garrett Fitzgerald, USA - Prostanoid biology and the role of peripheral molecular clocks in cardiovascular biology, metabolism and aging Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Patrick du Souich, Canada - Cytochrome P450, membrane carriers, disease, inflammation, rational use of drugs, clinical pharmacology David J. Webb, UK - hypertension, chronic kidney disease, endothelial function and dysfunction, arterial stiffness, health technology assessment, medicines regulation Don Birkett, Australia - Clinical pharmacology / pharmacokinetics and drug utilisation

One key aspect that her research group has devoted its efforts to over the past 15 years is expanding the toolkit of building blocks to include fluorinated aliphatic amino acids to improve the pharmacokinetic and physicochemical profiles of peptide / protein - based drugs and materials, respectively.

They provide researchers with access to additional skills, medicinal chemistry, pharmacokinetics, and evaluations of drug - like properties, which helps them determine whether their discoveries could lead to viable drugs to treat diseases.

The New Therapies Program works closely with the adult cancer research program — monitoring the effectiveness the pharmacokinetics and toxicity of the drugs to determine the best dosages for young patients.

«When you deliver it using a nanoparticle vehicle, you essentially modify the pharmacokinetics of the drug molecule because it is now attached to the particle.

Pharmacokinetic variability, hepatic metabolism of drugs, clearance with renal elimination, drug interactions (8) http://www.cnn.com/2007/HEALTH/conditions/09/26/unapproved.drugs/index.html NEW YORK (CNN)-- Every year, doctors write approximately 65 million prescriptions for drugs not yet approved by the U.S. Food and Drug Administration, the federal agency that regulates prescription drdrug interactions (8) http://www.cnn.com/2007/HEALTH/conditions/09/26/unapproved.drugs/index.html NEW YORK (CNN)-- Every year, doctors write approximately 65 million prescriptions for drugs not yet approved by the U.S. Food and Drug Administration, the federal agency that regulates prescription drDrug Administration, the federal agency that regulates prescription drugs.

Its drug candidates are designed to improve the pharmacokinetics, pharmacodynamics, half - life, bioavailability, metabolism or distribution of drugs and improve the overall benefits and use of a drug for the patient.

It has been known that salt content in a diet can influence pharmacokinetics of the antiepileptic drug potassium bromide.

The University of Florida's online graduate certificate * program in Forensic Toxicology is comprised of five 3 - credit courses and has been designed to meet the needs of today's working professionals; providing a strong working background in analytical techniques, pharmacokinetics, drug elimination and toxicology.

Despite the wide use of chlorambucil in cats, the pharmacokinetic parameters (i.e. how the body absorbs, metabolizes and eliminates the drug) have not been previously studied in cats.

Proposed mechanisms of action for each drug, and known pharmacokinetic profiles in dogs are discussed.

I have working experience in pharmacokinetic modeling, metabolite kinetics, in vitro drug metabolism and mass spectrometry.

Tags for this Online Resume: mass spectrometry, drug metabolism, pharmacokinetics, DMPK, bioanalytical, LC - MS / MS

Monitors and analyzes drug therapy regimens with health care providers (based upon pharmacokinetics, patient disease state status, and medication history) to provide the most effective, least toxic, and most economical drug treatment plan.

Tags for this Online Resume: ADME, Pharmacokinetics, Bio-analytical Chemistry, Drug Development, Quantification of drugs, Mass Spectrometry Lab

I have been working in the Biotechnology industry for the last 9 years in the Pharmacokinetics & Drug Metabolism group at Amgen.

Pharmacists have specialty training in pharmacokinetics and pharmacodynamics and have demonstrated improvements in drug utilization and patient outcomes in outpatient collaborative practice models [6][7].

Psychotropic drugs in mothers» milk: A comprehensive review of assay methods, pharmacokinetics and of safety of breast - feeding