Part of the problem is likely related to the fact that
the drug reduces cholesterol, which is essential for proper fetal development.
If
a drug reduces cholesterol, it is said to be «effective.»
Not exact matches
But they've been hampered by somewhat skeptical physicians who still aren't sure that the
drugs are worth their price (their topline costs are around $ 14,000 per treatment course); part of the problem is that it's unclear whether or not those dramatic
cholesterol reductions actually translate into broader health outcomes like a
reduced risk of stroke or heart attack in heart disease patients.
Herper homes in on a relatively new class of super-powerful (and super expensive)
cholesterol - busting
drugs called PCSK9 inhibitors (which were just shown to
reduce death from any cause, and particularly heart - related conditions), and how patients with staggeringly high
cholesterol who would benefit from the treatments had to wrangle with insurance companies that refused to cover them over their high prices.
In fact, the US Food and
Drug Administration (FDA) has even approved advertisers and food packagers from stating that Psyllium is an effective ingredient to lower
cholesterol and
reduce the risk of heart disease.
A new study shows that the
drug fenofibrate might
reduce the risk of cardiovascular events in patients with type 2 diabetes who have high levels of triglycerides and low levels of «good»
cholesterol, despite being treated with statins.
ORLANDO, Fla. — Adding a pharmaceutical form of the B vitamin niacin — but not the
drug ezetimibe — to a
cholesterol - lowering statin
drug appears to
reduce artery plaque buildup in patients with coronary artery disease, according to much - anticipated results announced at a press conference November 15.
Statins, a class of
drugs that lower
cholesterol in the blood, are prescribed to
reduce the incidence of cardiovascular events such as heart attacks and strokes.
The researchers found that treating the mice with a
drug that lowers blood sugar levels not only
reduced the numbers of circulating monocytes and neutrophils but also allowed plaques to normally heal after blood
cholesterol was
reduced.
The analysis found that statins were more likely to
reduce the risk of death when LDL
cholesterol levels were 100 milligrams per deciliter (mg / dl) or greater, whether or not they were used with other LDL - lowering
drugs.
A statin
drug commonly used to lower
cholesterol is not effective in
reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..
«If modifying
cholesterol levels in the brain early in life turns out to
reduce amyloid deposits late in life, we could potentially make a significant difference in
reducing the prevalence of Alzheimer's, a goal of an enormous amount of research and
drug development effort.»
We get heavily hyped
drugs like Avastin, which shrank tumors without adding significant time to cancer patients» lives (and increased the incidence of heart failure and blood clots to boot); Avandia, which lowered blood sugar in diabetics but raised the average risk of heart attack by 43 percent; torcetrapib, which raised both good
cholesterol and death rates; and Flurizan, which
reduced brain plaque but failed to slow the cognitive ravages of Alzheimer's disease before trials were finally halted in 2008.
Plus, they were more likely to be using beta blockers, a
drug frequently prescribed to lower blood pressure, and statins that
reduce cholesterol levels.
Despite lowering low - density lipoprotein (LDL), known as «bad»
cholesterol, while markedly increasing levels of high - density lipoprotein (HDL), or «good»
cholesterol, a large clinical trial to investigate the
cholesterol drug evacetrapib was discontinued early after a preliminary analysis showed it did not
reduce rates of major adverse cardiovascular events, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.
Certain
cholesterol levels, for example, have been proven to adequately reflect a patient's risk of having a heart attack, so a
drug that
reduces those levels may reasonably be presumed to lower cardiovascular mortality.
Taking that observation one step further, the researchers then asked whether
cholesterol - lowering statin
drugs, which other reports had shown could dramatically
reduce the risk of a heart attack in middle - aged people, benefit the very old (see «Greasing Aging's Downward Slide»).
Statin
drugs are widely used to manage high
cholesterol and
reduce the risk of cardiovascular disease.
Drugs that
reduce cholesterol levels in the cardiovascular system can strongly benefit people with diabetes or related conditions, but
cholesterol in the blood generally can't cross into the brain, and
cholesterol metabolism is quite different in the brain, she points out.
Mipomersen (Kynamro)
reduces low - density lipoprotein (LDL)
cholesterol by silencing a gene that produces apolipoprotein B - 100, a building block of LDL; the
drug can treat familial hypercholesterolemia, an inherited disease that may cause heart attacks at an early age.
A healthy diet, regular exercise,
cholesterol - lowering
drugs, and lifesaving surgeries can
reduce your risk of having — or dying from — a heart attack.
Although dietary changes,
cholesterol - lowering statins, and hypertension
drugs such as beta - blockers are far from a surefire way to prevent Alzheimer's, these and other treatments that promote healthy blood vessels may be a practical way for people to
reduce their risk, the researchers say.
The U.S. Food and
Drug Administration allows certain products containing fiber to bear a label claiming that they may
reduce the risk of heart disease as part of a diet low in saturated fat and
cholesterol.
Gemfibrozil (a fibrate
drug for
reducing cholesterol) should not be used with statins, and niacin may interact with many
drugs, including blood - pressure and diabetes medicines.
No one really likes having to take medications, but millions of people in the United States (and around the world) are on
cholesterol - lowering
drugs to
reduce their heart disease risk.
Legumes such as lentils, chickpeas, beans and split peas may
reduce cholesterol so much that consumers may be able to get off their
cholesterol - lowering statin
drugs, but to profoundly alter heart disease risk we may have to more profoundly alter our diet.
A healthy diet, regular exercise,
cholesterol - lowering
drugs, and lifesaving surgeries can
reduce your risk of having — or dying from — a heart attack.
Statin
drugs work very well at
reducing cholesterol measurements in the blood.
What this also means is that when you artificially lower your
cholesterol with a statin
drug, which effectively
reduces that plaque but doesn't address the root problem, your body is not able to compensate any longer, and as a result of lack of
cholesterol sulfate you may end up with heart failure.
When it came to decreasing fats in the blood and
reducing harmful LDL
cholesterol, the olive leaf extract outperformed the prescription
drug.
It is no surprise that decades of recommendations to
reduce consumption of
cholesterol and perhaps overzealous prescription of statin
drugs have paralleled the rise in AD incidence.6
Statins are the most commonly prescribed
drug in North America, used to
reduce cholesterol levels and decrease the risk of cardiovascular events such as stroke and heart attack.
Berberine when combined with oral lipid lowering
drugs was better than lipid lowering
drugs alone in
reducing total and LDL
cholesterol and raising the level of HDL.
... If you
reduce your total
cholesterol to well below 150mg / dl, you may...
reduce the
drug dosage — and in some cases, eliminate it altogether.»
Statin
drugs work by preventing the formation of
cholesterol, and
reducing LDL
cholesterol, which is considered the «bad»
cholesterol.
In this booklet, Dr. Lee talks about how heart disease in women is different, and explains why your diet does not necessarily affect your
cholesterol level, why
cholesterol drugs often don't
reduce the risk of heart disease, and why you might not want to put too much weight on blood pressure and
cholesterol numbers.
But Dr. Agatston, you may not be aware that studies around the world have shown that people on a high fiber vegetarian diets can
reduce their
cholesterol almost as much as people on statin
drugs.
Research shows that taking a specific product containing eicosapentaenoic acid as ethyl eicosapentaenoic acid (Vascepa by Amarin) by mouth along with dieting and
cholesterol - lowering
drugs called «statins»
reduces levels of triglycerides in people with very high levels.
His plan was to put a group of patients on a diet of low - fat, plant - based foods along with small quantities of low - fat dairy products and minimal amounts of
cholesterol -
reducing drugs.
Their statistical analysis of the results implied a 24 % reduction in the rate of coronary heart disease in the group taking the
drug compared with the placebo group; however, nonheart disease deaths in the
drug group increased — deaths from cancer, stroke, violence and suicide.7 Even the conclusion that lowering
cholesterol reduces heart disease is suspect.
In fact, the U.S. Food and
Drug Administration (FDA) agreed that 25 grams per day of soy protein, as part of a diet low in saturated fat and
cholesterol, may
reduce the risk of heart disease (http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr;sid=502078d8634923edc695b394a357d189;rgn=div8;view=text;node=21%3A2.0.1.1.2.5.1.13;idno=21;cc=ecfr).
Bile acid sequestrant
drugs that are used for high
cholesterol (cholestyramine, colestipol, colesevelam) may
reduce the liver's reabsorption of bile from the gut and may
reduce the absorption of thyroid medication
Experts, including physicians at the prestigious Cleveland Clinic, maintain that CoQ10 supplementation can cut the risk of having a repeat heart attack, lower (excessive) blood pressure levels and even help
reduce the side effects of statin
drugs used to lower
cholesterol.
* The U.S. Food and
Drug Administration has approved the following health claim for soy protein: «25 grams of soy protein in a daily diet low in saturated fat and
cholesterol can help
reduce total and LDL
cholesterol that is moderately high to high.»
The biggest problem is that statin
drugs don't just
reduce cholesterol — often they come with a slew of side effects such as muscle pain, weakness, fatigue, poor memory, low sex drive, depression and a higher susceptibility to infections.
The Anti-Aging Bottom Line: Using dietary means instead of
drugs to
reduce cholesterol helps you avoid harmful
drug side effects, such as muscle and liver damage.
A study published in the American Journal of Clinical Nutrition, which found that, as part of a diet rich in heart healthy foods such as soy, viscous fiber and plant sterols, almonds can
reduce cholesterol levels as much as first generation statin
drugs.
The effort to
reduce cholesterol with dangerous statin
drugs has made a lot of money, maybe more than any other type of
drug on the market.
Statin
drugs that
reduce cholesterol in the body are much more harmful than beneficial, even though they do lower
cholesterol readings.
Nevertheless, the finding that it
reduced cholesterol as effectively as a statin
drug is very impressive and should be further investigated.