Sentences with phrase «drug research trials»

Not exact matches

This genomic information would then be fed to Watson, using its supercomputing powers and Sloan Kettering's oncology precision medicine database to sift through the latest cancer research and drug trials.

These companies tend to have more dependable streams of revenue and a more diversified «pipeline» of drugs in the research and development stages, making them less dependent on make - or - break drug trials and their shares less volatile.

A stroke drug invented at The Scripps Research Institute has shown signs of safety and efficacy in a mid-stage clinical trial.

That's because it costs on average, $ 1.2 billion dollars to bring a new drug to market — from the time it is a twinkle in a scientist's eye, through a decade or more of lab research, to clinical trials and finally FDA approval.

The Pharmaceutical Research and Manufacturers of America reported in 2003 that drugs entering Phase I clinical trials have a 15 % probability of becoming a marketable product.

This includes a stem cell research centre, a network of drug discovery institutes and a # 20 million global clinical development fund dedicated to supporting Phase I and II clinical trials; and a # 2 million collaboration between University of Cambridge and University College London that will use donated cells from people with Alzheimer's to test potential new treatments

It tells the story of «the guinea pigs»» the people most likely to be research subjects in Phase I trials, which test the safety of a drug under development by giving it to healthy subjects and examining any side effects they experience.

Ahead of David Cameron's announcement later today that patients will be given the opportunity to trial pioneering new drugs before the end of clinical tests, David Willetts, Science and Universities Minister has spoken of the need for a «very clear route» from the research lab to NHS patient.

The U.S. Food and Drug Administration banned it from conducting human trials, and Wilson left his post at the now defunct institute (but he continued doing research at Penn).

The Food and Drug Administration immediately terminated all gene therapy trials there, and the incident prompted federal regulators to establish new rules for human gene therapy research.

«This research is highly significant as it implies that a commercially available drug, amphotericin B, which has never been used before for patients with gliomas, may be a novel treatment to consider in future trials of patients with this frequently lethal cancer,» says Dr. Rutka.

Clinical research focuses on interventional human trials to evaluate drugs and treatments in a controlled setting.

The pioneering research led by academics from the Sheffield Institute of Translational Neuroscience (SITraN), in collaboration with scientists from the University of York, supports the fast - tracking of the drug ursodeoxycholic acid (UDCA) for a clinical trial in Parkinson's patients.

A clinical trial conducted by researchers at the Virginia G. Piper Cancer Center Clinical Trials, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen), showed that a new drug called MM - 398, given in combination with 5 - flourouracil (5FU) and leucovorin, produced a significant overall survival rate in patients with advanced, previously - treated pancreatic cancer.

Previous research raised the possibility that HDL might not be quite as protective against heart disease as generally believed by cardiologists, especially after several clinical trials of HDL - raising drugs showed little or no effect.

Research has also found that the drugs are flushed quickly from the body, and current trials require multiple injections.

The new drugs offer the hope of treatment to perhaps thousands of HIV patients who have stopped responding to other medications, says William Towner, medical director of the Kaiser Permanente HIV / AIDS research trials program and member of the study team, which reported its findings online today in The Lancet.

«A drawback of clinical trials is that they are highly controlled and highly monitored to ensure strict adherence to protocol; however, that's not how people take drugs in the real world,» said Andrea V. Margulis, MD, ScD, senior research epidemiologist and co-author of the paper.

Called the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) and funded by the drug giant Novartis, the trial also found fewer cases of lung cancer in those on the treatment, rekindling basic research findings hinting that the same inflammatory pathway may initiate or spur the growth of such tumors.

The German biotech CureVac, for example, has brought mRNA - based vaccines for rabies and cancer to clinical trials, and Karikó now heads a research team at BioNTech in Mainz, Germany, that focuses on mRNA - based drugs.

Dr. Criner said that despite the clinical trial's finding that the statin drug did not help with COPD flare - ups, information gleaned from this study should help inform other research into the inflammatory nature of COPD.

According to lead author Mr James Oliver of the Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, UK, «in current clinical practice, RA drugs are administered on a trial and error basis; there are no clinical biomarkers of response to guide treatment decisions.

To develop better drugs, scientists are trying to move beyond trial and error and to base their research on our growing knowledge of what causes pain.

University of Calgary researchers including Luchman, Weiss and Dr. Greg Cairncross — director of SACRI, and leader of the Terry Fox Research Institute (TFRI) «Therapeutic Targeting of Glioblastoma research program at the university — are now working with cancer researchers Dr. Warren Mason (Princess Margaret Cancer Centre in Toronto) and Dr. Lesley Seymour (Director of the NCIC Clinical Trials Group's Investigational New Drug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with gliobResearch Institute (TFRI) «Therapeutic Targeting of Glioblastoma research program at the university — are now working with cancer researchers Dr. Warren Mason (Princess Margaret Cancer Centre in Toronto) and Dr. Lesley Seymour (Director of the NCIC Clinical Trials Group's Investigational New Drug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with gliobresearch program at the university — are now working with cancer researchers Dr. Warren Mason (Princess Margaret Cancer Centre in Toronto) and Dr. Lesley Seymour (Director of the NCIC Clinical Trials Group's Investigational New Drug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastDrug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastdrug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastdrug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastoma.

And although the programme is set to award a major clinical - trial contract later this year, the drug being tested would treat not exotic, untreatable pathogens but ordinary influenza, a disease already heavily researched outside the Pentagon.

Peter Parker of the Imperial Cancer Research Fund in London says he is delighted that a drug targeting signal transduction is now in trials.

An affordable hepatitis C combination treatment including the new drug candidate ravidasvir has been shown to be safe and effective, with extremely high cure rates for patients, including hard - to - treat cases, according to interim results from the Phase II / III STORM - C - 1 trial presented by the non-profit research and development organisation Drugs for Neglected Diseases initiative (DNDi) at the International Liver Conference in Paris.

«It's the first clinical trial of a drug with this action in patients with cancer,» says Peter Lewis, the director of research and development.

A drug with similar effects might generate substantial marketing... The very high heterogeneity... of effects among trials in the accompanying study highlights a research opportunity — to identify how to maximise the effect.»

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).

This drug has been tested in clinical trials for the treatment of sepsis, and these findings suggest a therapeutic potential for the drug in the treatment of CCMs, although considerable research remains to be done.

Finally, the research team tested a drug already in clinical trials (IGF - 1) on a cohort of study participants, finding that it provoked a reversal of neural alterations, though the degree of response varied by ASD individual.

TLC's goal is to smooth the path for a drug going from the scientist doing basic research, to the organization sponsoring clinical trials, to the drug company that eventually manufactures it.

The authors point to studies of harmful and beneficial effects of thrombolytic and antiarrhythmic drugs for myocardial infarction, for example: «Not only would systematic reviews... have reduced waste resulting from unjustified research, they would also have shown how to reduce morbidity and sometimes mortality, both in patients allocated to relatively less effective or actually harmful treatments in unnecessary trials, and in patients generally,» the authors write.

Clinical trials to treat neurodegenerative diseases such as Alzheimer's have a historically high failure rate, partially because potential drugs are derived from research in nonhuman models.

Although human drug trials are several years away, Leinwand has cofounded a company to fund her research.

Indeed, the authors note the speed with which a second FDA - approved drug believed to have promise in subduing HIV, Deferiprone, has moved directly from tests in culture to a phase I human trial conducted in South Africa, thanks to previously published results now reinforced by additional research in culture described in the current paper.

In his current role, he combines population research and functional genomics strategies to inform drug development from preclinical through phase 3 trials.

The trials aren't exactly research: Nobody is using them to figure out whether a drug works or is safe before it's released to the general public.

«We are delighted to receive this CIRM grant that will drive our translational research from the laboratory to the clinic,» Slamon said, «and allow us to test our targeted drug in a phase I clinical trial.»

Commenting on the study, Dr Andres Poveda, Head of the Gynecological Oncology Clinic at Fundación Instituto Valenciano de Oncología, Valencia, Spain, who was not involved in the research, said the CIRCCa study is the second recent trial to show the benefit of adding an antiangiogenic drug to chemotherapy in cervical cancer.

Pharmacogenomics — the study of how genes affect responses to drugs — is becoming more important in drug - development research and clinical trials, with a view toward decreasing side effects and increasing the efficiency and efficacy of drugs in patients with the right genetic profiles.

Clinical researchers can end up anywhere from academia, where posts are based at university medical school research units or at hospital research units, to pharmaceutical or biotech companies, or in contract research organisations (CROs), which carry out clinical trials for drug or biotech companies.

For example, one firm has engaged Parexel International, a global contract research organisation (CRO) based in Waltham, Massachusetts, to run a trial of an established adult migraine drug in children aged 6 to 17, across more than 20 countries.

«The ultimate goal of this research will be to advance HIF - 1alpha stabilizers toward clinical trials in humans, using versions of the drug that can be taken orally and reach the urinary tract,» Nizet said.

Despite lowering low - density lipoprotein (LDL), known as «bad» cholesterol, while markedly increasing levels of high - density lipoprotein (HDL), or «good» cholesterol, a large clinical trial to investigate the cholesterol drug evacetrapib was discontinued early after a preliminary analysis showed it did not reduce rates of major adverse cardiovascular events, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

Beginning with the Nazi Doctors» Trial at the 1946 Nuremberg Trial (1), coverage includes publication of Henry Beecher's «Ethics and Clinical Research» (2), The New York Times exposure of the public health service syphilis study in Macon County, Alabama (the infamous «Tuskeegee case»)(3), the University of Pennsylvania / Gelsinger gene transfer case, and The Washington Post series on international clinical drug testing abuses (4).

Furthermore, the findings also provide support for the amyloid cascade hypothesis, a hypothesis which is key in Alzheimer's research and which has recently been heavily questioned due to failed beta - amyloid based drug trials and treatment experiments.

The Progeria Research Foundation's lonafarnib trial ended in 2010, but the foundation is now monitoring 45 children from 24 countries who are taking the drug, as well as the cholesterol drug pravastatin and zoledronate, which prevents fractures.

Specifically, the research team found that the experimental drug CX456, part of the AMPAkine class in clinical trials for several neurological conditions, counters for the dampening effect of anesthesia on nerve signaling.