Sentences with phrase «drug resistant cancer»
«Surviving ovarian cancer: Scientists attack drug resistant cancer cells.»
https://www.sciencedaily.com/
Adult drug resistant cancer cells may contribute to this problem, and the authors discuss these and other cancer drug resistance mechanisms in their recent publication in the September issue of the journal Cancers.
Drug resistance is a major problem in cancer treatment, as drug resistant cancers are thought to be the primary cause of cancer relapse.
Our results also demonstrate the ability of a GHRH antagonist, MIA - 602, to be a potential new treatment for drug resistant cancers.
Not exact matches
Professor Josep Tabernero, a member of the scientific committee for the EORTC - NCI - AACR Symposium and head of the medical oncology department at Vall d'Hebron University Hospital and director of the Vall d'Hebron Institute of Oncology, Barcelona, Spain, commented: «These are encouraging results, which show that galeterone has significant clinical activity in men with castration - resistant prostate cancer that fails to respond to other drugs.
Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiratCancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiratCancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiratcancer, such as enzalutamide and abiraterone.
«Experimental drug combined with standard chemo may shrink treatment - resistant ovarian cancers, animal study shows.»
The stem cells may also be resistant to ordinary cancer drugs, causing the cancer to recur.
When patients with advanced ovarian cancer become resistant to one drug, clinicians usually prescribe a new drug.
Yet unlike other drug - resistant cancers, these tumours have no telltale mutations.
This time, she was given different chemotherapy — docetaxel and gemcitabine — as it was assumed that her cancer had grown resistant to the previous drugs, and, after several weeks, the tumours had shrunk right down.
In addition, the study proposes that treatment - resistant cancers may derive their naturally selected «fitness» from the very drugs that were initially meant to reduce their fitness.
Figure on the left: Analyzing the relative sensitivity of hundreds of cancer cell lines to commonly used anti-cancer drugs (each dot) reveals that cells with suppressed expression of one proteasome cap subunit are specifically resistant to treatments with the proteasome inhibitors MG132 and bortezomib.
The researchers then used a combination of existing United States Food and Drug Administration - approved drugs to target autophagy and found ovarian cancer cells to be highly sensitive to these drugs in several different mouse cancer models — even among cells resistant to standard chemotherapy.
In a trio of studies to be presented at the 57th American Society of Hematology (ASH) Annual Meeting and Exposition in Orlando, investigators at Dana - Farber Cancer Institute will present the results of clinical trials showing that new drug combinations can significantly extend the time in which multiple myeloma is kept in check in patients with relapsed or treatment - resistant forms of the disease.
These progenitor cells are often drug resistant and can initiate cancer development and are possibly involved in cancer relapse.
This work is being done in collaboration with Dr. Hasan Korkaya, assistant professor, Biochemistry and Molecular Biology at the Medical College of Georgia, who has developed drug - resistant cell lines, and with breast cancer clinicians.
Liu's ongoing studies are testing the ability of the three - in - one chimera to treat breast cancers that are resistant to Herceptin, a drug that targets HER2.
My cancer systems biology team at the University of California, Merced, is tackling diagnosis and treatment of therapy - resistant cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent cancer resistance.
«For example, some cancers may not impact many patients and some antibacterial drugs, such as that for drug - resistant tuberculosis, may not be profitable, but it is almost a responsibility of biomedical researchers in academics to do something about it.»
Though chemotherapy might kill most of the cancer, tiny populations of drug - resistant cancer cells manage to survive and propagate.
However, the researchers uncovered several mechanisms leading to tumor resistance, giving them insight into which drugs could combat the resistant cancer.
Some cancers that initially respond to targeted chemotherapy become treatment - resistant — and the drug itself may not be the culprit.
«One criticism of the PARP drugs is they are not active in patients who have developed resistance to other therapies, but we found veliparib appears to be effective in some platinum - resistant patients with recurrent or persistent disease,» said Robert L. Coleman, MD, lead author of the study and professor and vice chair of clinical research at the University of Texas MD Anderson Cancer Center, Houston.
To study nanodiamonds» usefulness for cancer treatment, Ho's group attached them to doxorubicin, a standard chemotherapy drug, and injected them into mice with drug - resistant breast and liver cancer.
And finally, they used the test to monitor a patient's blood throughout treatment, quickly picking up signs that the cancer was evolving genetically and might be becoming resistant to the drugs.
If a given drug cocktail kills 90 percent of the cancer cells but doesn't affect the remaining 10 percent, the resistant tumor cells can take over and cause the tumor to grow back.
Some compounds of the dozens of variations the scientists created exhibit potent cytotoxicities against certain cancer cells, including a drug - resistant cell line, Nicolaou said.
«The microgravity environment of the International Space Station is now being used for myriad lines of research, for example: vaccine development, finding novel molecular targets against drug - resistant pathogens, and testing of molecules to be used against osteoporosis or cancer,» Zea says.
A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute Cancer Institute study.
The study, recently published in the journal Oncotarget, set out to determine whether neratinib could be utilized, alone or in combination with other agents, to kill non-small cell lung cancer (NSCLC) cells that had become resistant to the drug afatinib.
Many investigators had assumed that once breast cancer cells developed resistance to tamoxifen, they would be resistant to all drugs that target the estrogen receptor, McDonnell explained.
In men whose prostate cancer spreads, doctors typically prescribe drugs that block testosterone production, but cancer cells eventually become resistant to this means of reducing the hormone, says Denmeade, a professor of oncology at the Johns Hopkins University School of Medicine.
«Osteoporosis drug stops growth of breast cancer cells, even in resistant tumors, study suggests.»
«Women with this type of breast cancer also frequently develop metastatic lesions that originate from drug - resistant cells.
A new phase 3 study in some of the most difficult - to - treat patients, women with endocrine - resistant disease, showed that the newly approved drug, palbociclib, more than doubled the time to cancer recurrence for women with hormone - receptor (HR +) positive metastatic breast cancer.
And for more on molecularly targeted cancer drugs, see the news story «Combining Targeted Drugs to Stop Resistant Tumors» (free full text with registration) in this week's issue of Scidrugs, see the news story «Combining Targeted Drugs to Stop Resistant Tumors» (free full text with registration) in this week's issue of SciDrugs to Stop Resistant Tumors» (free full text with registration) in this week's issue of Science.
«Now, we have toxin - resistant stem cells that can make and release cancer - killing drugs.»
Indomethacin killed both drug - resistant and drug - sensitive epithelial ovarian cancer cells.
A nanoparticle drug - delivery system that combines two complementary types of anticancer treatment could improve outcomes for patients with pancreatic cancer and other highly treatment - resistant tumors while decreasing toxicity.
There's a need for ways to find these cells and to study them, and importantly, to develop drugs that target them, because these cancer stem cells are resistant to chemotherapy drugs that target the main tumor.
Researchers from BIND Biosciences in Boston filled nanoparticles with the cancer drug docetaxel and injected them into the blood of 17 people who had cancers that are normally resistant to the drug.
«Cell - weighing method could help doctors choose cancer drugs: Technique may predict which therapies a patient is most sensitive or resistant to.»
Because it more effectively induces cancer cell apoptosis in p53 - deficient tumors, FL118 is especially effective against late - stage cancers, which usually lose functional p53 and are resistant to DNA - damage drugs.
Rather than trying to eradicate all cancer cells, an evolution - based approach of keeping a few alive has stopped tumours becoming drug resistant in mice
«We are excited and gratified by these remarkable results, which could lead to a new way to treat these drug resistant metastases of ER + breast cancers and / or prevent their metastases in the first place.»
Unlike ER - positive cancers that respond well to treatment, those that are drug - resistant spread elsewhere in the body even with aggressive therapy.
«New models of drug - resistant breast cancer point to better treatments.»
Crews noted that RNA splicing - targeted agents have been shown to have activity in a variety of solid tumors so the findings may be relevant to a variety of cancers, such as breast and drug - resistant melanoma.
But what was more remarkable was that the CA125 - negative cells were clearly resistant to the drugs normally used to treat serous cancers.»