Sentences with phrase «drug rosiglitazone»

The diabetes drug rosiglitazone has been under intense scrutiny since a 2007 study in the New England Journal of Medicine looked at more than 40 clinical trials and linked the drug's use with increased risk of heart attack and death from heart disease.

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

The researchers showed that the type 2 diabetes drug rosiglitazone, which increases insulin sensitivity, also protects neurons from ADDLs.

They also showed that they could manipulate Klotho expression pharmacologically using the anti-diabetic drug rosiglitazone, which resulted in decreased levels of Wnt5A.

Not exact matches

Although both studies have limitations, an editorial accompanying Graham's paper considered the findings compelling: «Accumulating concerns about rosiglitazone make it difficultto advance a cogent argument regarding why, exactly, a patient might want to receive the drug.»

The researchers showed that a two - day treatment regimen with partial or selective PPAR - γ agonists (Telmisartan and Rosiglitazone — both FDA - approved drugs) ameliorated the pathological outcomes of infection in mice by inducing expression of glucose transporters.

In these mouse tests, WWL113 — without any optimization for use as a drug — performed about as well as the FDA - approved diabetes treatment rosiglitazone (Avandia).

The latest case concerns GlaxoSmithKline's Avandia (rosiglitazone), an anti-diabetes drug linked to heart attacks.

Clinical trials of GlaxoSmithKline's diabetes drug Avandia (rosiglitazone) and Merck's anti-inflammatory Vioxx (rofecoxib) revealed an elevated cardiac risk from the drugs, but relevant findings were held back from regulators or never published.

«Our post-trial analysis compared patients treated with rosiglitazone to patients not receiving any TZD drug.

«It's not a pure randomly assigned trial of rosiglitazone versus a different drug,» Bach says.

Metformin is also sold under the brand names Glucophage and Glucophage XR, and is found in pills that combine two types of antidiabetes medication, such as Glucovance and Metaglip (which combine metformin with a sulfonylurea drug) and Avandamet (a combination of metformin and rosiglitazone, a thiazolidinedione medication).

The researchers found that berberine performed as well as three well - known diabetes drugs — metformin, glipizide and rosiglitazone — and also helped to lower LDL cholesterol and triglycerides.

One big review of 14 studies found that berberine extracts are equally as effective at lowering insulin as the common diabetes drugs metformin, glipizide, and rosiglitazone.

Furthermore, the best part is that the study is just one among dozens; a large review of 14 studies found that berberine is as effective as pharmaceutical oral diabetes drugs such as glipizide, metformin and rosiglitazone.

The only thing rosiglitazone drugs like Avandia do is to help lower blood glucose, which has virtually no influence on the long - term damage due to type 2 diabetes.

Avandia (rosiglitazone) is the poster child for what is wrong with the drug treatment of type 2 diabetes.

The Impact of a Drug Safety Warning on Discussions between Doctors and Their Patients; the Case of Rosiglitazone