Sentences with phrase «drug sensitivity»
Drug sensitivity refers to how our bodies respond to medications. Some people may be more sensitive to certain drugs, meaning they can have stronger side effects or reactions. It's important for doctors to know about drug sensitivity so they can choose the right medication and dosage for each person. Full definition
Kolaparthi, Krishna Grade: 8 Katherine Stinson Middle School - San Antonio, TX Project Title: Differential Drug Sensitivity of Human Pancreatic Cancer Cells
student.societyforscience.org
Help create a proactive plan for your dog's health care with more than 130 genetic mutation tests including MDR1 for drug sensitivity.
Drug sensitivities result from a mutation in the multi-drug resistance gene (MDR1).
ABSTRACT: A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in two breeds from the collie lineage.
About a year ago, his research team identified a mutation in E. coli that increased drug sensitivity by blocking an efflux pump complex called AcrAB - TolC.
In addition to characterizing this heterogeneous disease, we have identified representative cell culture models that display differential drug sensitivity.
Biogeographical data is useful in screening for disease risk and drug sensitivity associated with certain ethnic groups.
Resources include extensive genomic and drug sensitivity data sets, orthotopic xenografts and preclinical models.
Some owners also report drug sensitivities.
An assessment of 6,226 samples from patients with 17 different cancer types taken from The Cancer Genome Atlas has revealed new information about RNA editing events in tumors versus normal tissue, and provided evidence that RNA editing could selectively affect drug sensitivity.
After exploiting a technology that allowed them to activate each of nearly 16,000 genes individually in human melanoma cell lines containing mutant BRAF, the authors then treated the panel of cells with the drugs and monitored which cells showed altered drug sensitivity.
In strains of tuberculosis that have developed drug resistance mutations, researchers have identified a secondary pathway that can be activated to reinstate drug sensitivity.
«What we're finding with THC is that you get a very clear spike in drug sensitivity right when the females are ovulating — right when their estrogen levels have peaked and are coming down,» she said.
«Instead, after a few population doublings they go back to the normal gene expression pattern and rapidly reacquired drug sensitivity.»
In project on BRAF - mutant melanoma and EGFR - mutant non-small cell lung cancer, we conceived a novel drug sensitivity metric, the DIP rate, that makes it possible to incorporate drug - induced proliferation rates in predictive models of response.
It even tests for canine drug sensitivity (MDR1) and provides a prediction of your dog's adult weight.
This test is performed at the Washington State University College of Veterinary Medicine and is extremely accurate in predicting drug sensitivity.
While not all Border Collies will develop these issues, it is important for you to be aware of them if you are considering adding this breed to your home: Collie Eye Anomaly, Epilepsy, Hip Dysplasia, Various Drug Sensitivities, Deafness, Progressive Retinal Atrophy and Hypothyroidism.
In addition to the four required tests, OESCA recommends testing and reporting cardiac screening, BAER (hearing) testing, and DNA tests for Multiple Drug Sensitivity (MDR1 mutation), Primary Ciliary Dyskinesia (PCD), and Cerebellar Degeneration.
«Cell of origin affects malignancy and drug sensitivity of brain tumors.»
Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS - derived hepatocytes.
Resulting attractors point to distinct phenotypes whose relevance is underlined by their differential drug sensitivity.
At Washington State University's College of Veterinary Medicine you can get your dog tested for drug sensitivity and keep up with the latest research.
Then they linked the drug sensitivity of the tumor cells to the profile of genes expressed in those cells.
«New «driver» to assess cancer patient survival, drug sensitivity: RNA editing events another way to investigate biomarkers and therapy targets.»
Cancer specialists have long looked at genetic mutations and DNA copy changes to help predict patient survival and drug sensitivity.
Working with rats in her laboratory, Craft said she and her team «routinely manipulate hormones and follow females across their cycles to see if their drug sensitivities change along with their hormones.
«We show that the cell of origin is important for the malignancy and drug sensitivity of glioblastoma cells, and that the findings can also be applied to glioblastoma cells from patients.
Indeed, the researchers found that simvastatin increased the drug sensitivity of MDA - MB - 231 cells and inhibited the cells» ability to metastasize when injected into mice.
These examples underscore the value of gene expression profiling for revealing subtle mechanisms of drug sensitivity and resistance and providing clues into which drugs might be most effective when tested in combination, according to the authors.
Applying these methods to prostate cancer cell lines, the researchers found that accurate predictions of drug sensitivity could be achieved using either genomics data or phosphoproteomics data alone.
From 2008 - 2010, he was supported by the CGGH to study phenotypic variation in the drug sensitivity of Plasmodium falciparum isolates collected Kilifi District, and to investigate genotype - phenotype associations using genome sequencing data generated on these isolates at the Wellcome Trust Sanger Institute.
In a study published in Cell Reports, researchers led by Lene Uhrbom, Uppsala Univeristy / SciLifeLab, have discovered a correlation between the cell type from which the tumor originates and the growth and drug sensitivity of the tumor.
DIP rates can also be used to identify molecular and / or genetic determinants of drug sensitivity and resistance, in large - scale high - throughput screens.
They include fatigue, an inability to fall asleep, waking up in the middle of the night, difficulty getting up in the morning, easily gaining weight and difficulty losing it, low libido, reactive hypoglycemia, food sensitivities, drug sensitivities, PMS, fertility issues, anxiety, heart palpitations, mild depression, and frequent colds and flus.
Important information and the latest research on Collies and drug sensitivity, particularly to certain pharmaceuticals in the treatment of heartworm and mites.
We exploited breed phylogeny and reports of drug sensitivity to survey other purebred populations that might be genetically at risk.