Sentences with phrase «drug target for»
The other grant goes to Sheila Torres, BS, DVM, MS, PhD, DACVD, and Lucy Vulchanova, BS, PhD, of the University of Minnesota College of Veterinary Medicine, for their proposal titled, «A new drug target for improved epidermal barrier function in atopic dermatitis.»
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While I am not getting into TNF science, if you want to understand more, TNF receptor 2 pathway: drug target for autoimmune diseases, as well as TNF receptor 2 and disease: autoimmunity and regenerative medicine, as a start, helped me to better understand TNF.
Through a new study that explores one aspect of how the virus hijacks host cell machinery to replicate itself, UNC Lineberger Comprehensive Cancer Center researchers have gained insight into the workings of a potential drug target for hepatitis C.
But successful demonstration of SLC6A14 as an effective drug target for treatment of selective subtypes of cancer would provide new hope even for patients with other types of cancers.
SLC6A14 is not a universal drug target for all types of cancers as is the case with all of currently available anti-cancer drugs.
We have identified a novel amino acid transporter, SLC6A14, as a drug target for cancer treatment; this transporter has functional features superior to those of SLC1A5, SLC7A5 and SLC7A11 to support tumour growth.
Identifying additional components of the alt - EJ pathway and understanding the crosstalk that exists between alt - EJ and other pathways could lead to the discovery of new potential synthetic lethal interactions and as such new potential drug target for cancer treatment (Figure 2B).
Hsp90 is an important drug target for cancer and other diseases.
Identifying a drug target for ageing is a crucial step in achieving this and by targeting GSK - 3, we could discover new ways of controlling the ageing process in mammals, including humans,» explained lead researcher, Dr Jorge Iván Castillo - Quan, previously at UCL Institute of Healthy Ageing, now at Harvard Medical School.
The sole drug target for existing treatments was found serendipitously, and no medications with fundamentally new mechanisms of action have been developed since the 1950s.
Of these, SLC24A4 and CACNA1H are potential candidate genes for BP regulation, and the latter is a drug target for a class of calcium channel blockers.
11/24/2008 UCSD Researchers Identify Potential New Drug Target for Chronic Leukemia Researchers at the University of California, San Diego (UCSD) and the Moores UCSD Cancer Center have discovered what could be a novel drug target for an often difficult - to - treat form of leukemia.
Researchers have demonstrated that the enzymatic activity of R5 receptor - type protein tyrosine phosphatases is a requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells and could be a promising drug target for treatment.
This is a welcome surprise, because it suggests a well - understood brain process might be a useful drug target for future HD research.
This receptor is therefore a well - established and thoroughly characterized component of lipid metabolism and a drug target for metabolic diseases.
Long - term goal of the project will be to visualize and manipulate tau expression also in a systemic context (organotypic slice preparations, mouse brain) by affecting the function of tau mRNA - containing neuronal granules as a potential drug target for the treatment of neurodegenerative diseases.
This work presents a possible new drug target for cancer and heart disease, and was published in the journal, Nature Communications, on 8 July 2016.
Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and Regensburg University, both in Germany, and the University of Lisboa, in Portugal, have discovered a promising potential drug target for cystic fibrosis.
«Potential new drug target for cystic fibrosis.»
In humans, Neuropeptide Y functions similarly to sNPF and has been studied as a possible drug target for obesity treatment.
«New research identifies drug target for dengue virus.»
Researchers at the La Jolla Institute for Allergy and Immunology, in collaboration with colleagues the University of California, San Diego, identified a novel drug target for the treatment of rheumatoid arthritis that focuses on the cells that are directly responsible for the cartilage damage in affected joints.
«Drug target for triple - negative breast cancer found in new study.»
It might be a potential drug target for the treatment of the disease, concludes new research from the RIKEN Brain Science Institute in Japan.
Autophagy might therefore be a potential drug target for the treatment of Alzheimer's disease,» he adds.
A team of researchers led by UC San Francisco scientists has identified a new drug target for triple - negative breast cancer, an aggressive disease subtype that has the poorest outcomes and accounts for as many as one in five cases.
Gorfe said that understanding the dynamics of Ras proteins is critical to its study as a potential drug target for cancer.
«Although it is unknown how the genes regulate blood pressure,» Zhu added, «our findings contribute to better understanding of blood pressure pathways that can lead to future development of drug target for hypertension and may guide therapy for clinical care.»
If it emerges that it is indeed a «catcher's mitt» for α - synuclein, it could provide a drug target for a disease whose 10 million sufferers are sorely in need of new medicines.
«Mouse study reveals potential drug target for arthritis caused by chikungunya virus: A specific immune system proteinase may promote arthritic inflammation after viral infection.»
Overall the findings suggest that granzyme A could serve as a potential drug target for anti-inflammatory treatments for chikungunya — and perhaps also for other inflammatory diseases.
Identifying a drug target for aging is a crucial step in achieving this and by targeting GSK - 3, we could discover new ways of controlling the aging process in mammals, including humans,» explained lead researcher, Dr Jorge Iván Castillo - Quan, previously at UCL Institute of Healthy Aging, now at Harvard Medical School.
«Epigenetic alteration a promising new drug target for heroin use disorder.»
The new technology, described in the journal Molecular Cell, offers a new way to seek drug targets for many diseases, not just Parkinson's, says Timothy Lu, an MIT associate professor of electrical engineering and computer science and of biological engineering.
It is proving invaluable in identifying biomarkers and pinpointing potential drug targets for many diseases.
About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).
In addition to running his own lab, he directs the Applied Neurotherapeutic Research Group, a collaborative research initiative funded jointly by SFI and Wyeth, to understand the molecular underpinnings of changes in behavior and to identify new drug targets for diseases such as schizophrenia.
He hopes that further studies may identify novel approaches to immune - based cancer therapy or reveal new drug targets for inflammatory diseases.
Further investigation of the signaling pathways of pre - and post-LTP should reveal new drug targets for treating pain and anxiety.
If additional work supports the finding, the study may provide researchers with potential new drug targets for the disease.
«New drug targets for Ras - dependent cancers have long been sought,» said Arvin Dar, PhD, Assistant Professor of Oncological Sciences and Pharmacological Sciences at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and lead researcher on the study.
In this role, she focuses on the development of biologically relevant high throughput biochemical and phenotypic assays to enable high throughput screening (HTS) for a variety of drug targets for psychiatric disorders, and is currently interested in developing a high throughput calcium dynamics assay to monitor synaptic networks.
In an attempt to discover more effective drug targets for influenza, scientists have recently identified several genes and molecules that are crucial for influenza virus replication.
- catenin pathway could serve as drug targets for chronic and acute skin fibrosis conditions.»
Professor Moffatt said: «The genes we identified represent new potential drug targets for allergic diseases as well as biomarkers that may predict which patients will respond to existing expensive therapies.»
Stuber added, «The study of hormone - sensitive circuits that control motivational states may ultimately reveal new drug targets for these mood disorders.»
«This hampers integration of lipidomics into systems biology, and addressing it will improve our fundamental understanding of lipid biology, help identify new drug targets for therapy and discover lipid biomarkers from disease cohorts.»
Therefore, identification of molecules that affect both parasites during their release from infected host cells not only highlights robustness of the complementary screening approach we adopted, but also conserved drug targets for pan anti-parasitic drug development,» Dr Dhanasekaran Shanmugam from NCL added.
According to Sinclair, all of the mammalian SIRT genes (and their proteins) are possible drug targets for therapies aimed at extending life, as well as staving off age - related illnesses, such as Alzheimer's disease, cancers and metabolic disorders, like diabetes.
Two - pore channels control Ebola virus host cell entry and are drug targets for disease treatment