Sentences with phrase «drug targeting only»

This helps ensure selective drug targeting only at the site of the tumor.

Now, instead of our drugs targeting only diseased cells, we can target the immune system and provoke cells of the immune system to do the job for us,» said E. John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.

Not exact matches

Its first indication is a rare cancer that affects only 3,100 new patients each year, and the drug only targets roughly 30 % of those patients who do not respond to standard therapy.

In short, bears have suggested that oliceridine's target market is only a small fraction of the broader acute - pain space, and Trevena may be unable to convince payers to provide coverage for what will almost certainly be a far more expensive drug than morphine.

Rocky targeted not only dealers by mere USERS of drugs.

New drug - delivery particles could release therapeutic molecules in the body only after they reached their targeted diseased tissues.

«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk of the tumor,» said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Health.

CCR5 should remain «a very important target for vaccines and drugs,» he says, noting that they have found only one person with the double CCR5 defect in 300 people studied so far.

To address this challenge, our research group is using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function of the efflux pumps and thereby significantly improve safety and efficacy of cancer therapy.»

A potential adrenalinelike drug for weight control must target only the fat - cell receptors to avoid dangerous side effects in the cardiovascular system.

Delivery of these drugs, however, is not very efficient — only about 0.7 percent of chemotherapy nanodrugs reach their target tumor cells.

The PAM alone causes the natural painkillers to target only the right part of the brain at the right time, as opposed to drugs that bind to every receptor site throughout the body.

The findings reveal that only those antibodies that target the prion protein tail are suitable for use as potential drugs.

But researchers have had only a blurry picture of gp120's structure — not enough to design well - targeted drugs or mount an effective vaccine strategy.

For example, light - activated switches can fine - tune anti-cancer drugs, so they target only cancer cells and not healthy ones, thereby eliminating the side effects of chemotherapy.

Then, the Food and Drug Administration only has to ensure the product's safety for patients, not for the general public as potential terror targets.

By coating these particles with a peptide that is only able to target inflamed joint tissue, BNPs may be used to efficiently and selectively deliver drugs and diagnostic probes into arthritic joints.

Previously, only two targets of artemisinin have been identified, and their correlation with the powerful parasite - killing effect of the drug has been questioned.

The research team will now focus on making changes to the harmine and its relatives (harmalogs) to find drug candidates that target only beta cells.

Not only does it suggest new targets for drug development, but it also puts forward new behavioral changes that may be taken on the part of the infected individual in order to decrease the chances of developing a major disease and increase longevity.

Dopamine - blocking medications could target not only addictive drugs such as cocaine, but also compulsive behaviors like gambling or eating.

«Our findings have provided us not only with a new perspective on the role of astrocytes in cognition, but also with an exciting drug target to enhance memory and maybe even stave off memory decline in Alzheimer's disease,» says senior author Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease and professor of neurology and neuroscience at the University of California, San Francisco.

This pathway, the investigators report in Nature Medicine, is very similar to apoptosis (the controlled cell death program thought to exist only in multicellular organisms), but with subtle differences suggesting that it could be specifically targeted for anti-parasitic or - microbial drug development.

They're looking at the same types of pharmacological targets that maybe only used to be pursued at a drug company in the past,» says Philip Mayer, president of the American Association of Pharmaceutical Scientists in Arlington, Virginia.

The new method gives scientists more power not only to find new antibody - based therapies, but also to discover the biological pathways through which they work — pathways that may turn out to be more easily and cheaply targeted by small - molecule drugs.

What if drugs for cancer, cardiovascular disease, and other diseases can be targeted specifically and only to cells that need the medicine, and leave normal tissues untouched?

This is a target, not only in Friedreich's ataxia, but also in Parkinson's disease, so it is likely that collaborative drug development can move forward.»

A new drug that targets not only common cancer - causing genetic mutations in patients with non-small cell lung cancer (NSCLC), but also a form of the mutation that causes resistance to treatment, has shown promising results in patients in a phase I / II clinical trial.

Therefore, identification of molecules that affect both parasites during their release from infected host cells not only highlights robustness of the complementary screening approach we adopted, but also conserved drug targets for pan anti-parasitic drug development,» Dr Dhanasekaran Shanmugam from NCL added.

The team found that, while some drugs they tested this way were highly selective in the sense that they bound only to their intended protein targets, others showed evidence of strong bindings to additional, «off - target» proteins — which could produce their own biological effects.

And even genetically targeted drugs tend to affect more than only their stated target.

By synthesizing a nanoparticle that releases its siRNA cargo only after it enters targeted cells, Dr. Tariq M. Rana and colleagues showed in mice that they could deliver drugs that silenced the genes they wanted.

In a new study, published online June 6 in Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growth.

The Wyss team has unveiled not only a novel design of their «targeted EPO,» but also «targeted interferon alfa,» a cancer drug that can otherwise cause side effects including flu - like symptoms, mood fluctuations, and depression.

University of California, Berkeley researchers have now found a promising new drug target within that pathway that is appealing, in part, because it appears to control production of only a few percent of the body's many proteins, those critical to regulating the growth and proliferation of cells.

«Drugs that specifically target PGE2 pathways have already been developed and tested in animals, so our results have excellent potential for clinical translation, not only for the treatment of influenza, but other viral respiratory infections that interact with similar host immune pathways,» says senior study author Divangahi, who is also a member of the Infectious and Immunity Axis at the Research Institute of the McGill University Health Centre (RI - MUHC).

And they're designed to only target only the virus — hopefully minimizing side effects in any future drug.

Weiss and Yu also believe it can be used as a way to deliver drugs straight to the damaged tissue because the CHP targets only the damaged collagen.

«MYCN is often seen only as a marker for a poor prognosis, but it's critical to the disease and is a possible target for new drugs.»

These drugs can hit cancer harder than those targeting only one protein, and look promising for preventing or overcoming drug resistance.

Because Nav1.7 and Nav1.8's only jobs are to trigger pain, he says, a drug that targeted one or both of them as well as bark scorpion venom does would inhibit pain but let you keep other types of sensations (no more numb faces after a visit to the dentist).

Some scientists have had minor successes getting intravenous drugs past the barrier with the help of ultrasound or in the form of nanoparticles, but those methods can target only small areas.

Friedman notes that, even with the increasing number of drugs targeting specific molecular abnormalities that drive tumor growth, most patients are only treated with one such drug at a time.

Although some approved cancer drugs and others in development interfere with the same protein cleanup process, known as the ubiquitin - proteasome system, disulfiram targets only a specific molecular complex within this machinery.

These clam - like bots, which release a drug only when they reach and identify their target, could improve the treatment of many diseases.

Second, the researchers found that polypharmacy near the end of life is fueled not only by drugs prescribed for the purpose of symptom management (e.g. analgesics), but also by the frequent continuation of long - term preventive treatments and disease - targeted drugs.

Not only will this approach lead to much more targeted cancer drugs, but also considerably cheaper ones, the authors added.

This enables therapeutic antibody drugs to bind with extreme precision — only their target molecule should be an exact match.

A: Not only would it provide another treatment option for patients — there are only two FDA - approved ALS drugs — but it would lend evidence that the pathway is worth targeting, which, in turn, would lead to continued growth in research by academia and industry.

Currently, immunotherapy is approved by the Food and Drug Administration (FDA) to treat kidney cancer patients only after they've tried more traditional therapies, such as targeted therapies killing the cancer's blood supply.