Sentences with phrase «drug targets against»

Gauri's work focuses on identifying new drug targets against tuberculosis and understanding the mode of action against such targets.

«Revealing new drug targets against H. contortus could provide much - needed new treatment opportunities against parasitic worms in both animals and humans.

«Potential drug target against large family of parasites is identified: Researchers describe an enzyme that is likely vital for Plasmodium and other parasites of the Apicomplexan phylum.»

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.

The expense and effort are increased by the FDA requirement that any company applying for approval of a drug targeted against a specific gene - driven abnormality must also produce a diagnostic test for that abnormality.

Therefore, this complex is a highly promising therapeutic drug target against diabetes, obesity, Wolff - Parkinson - White Syndrome, cancer, and aging.

Not exact matches

There are actually a few of those drugs now: Cervarix, made by GSK, which targets strains 16 and 18; Gardasil, made by Merck, which preempts those two killers, plus strains 6 and 11; and Merck's Gardasil 9, which primes the body's immune system to create protective antibodies against — you guessed it — nine types of HPV.

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

With the uncertainty over Paolo Guerrero following his drugs ban, and with no other proven target man to play up front, Peru may be tempted to recall their former captain, who was on standby for the play - off second leg against New Zealand.

Rockland County District Attorney Thomas P. Zugibe on Wedesday announced the filing of criminal charges against 28 individuals on drug and other charges following a four - month undercover investigation targeting narcotics trafficking activities in the community.

H. contortus has become resistant to all major treatments against parasitic worms, so its genome is a good model to understand how drug resistance develops in this complex group of closely related parasites and will also reveal further potential drug and vaccine targets.

Two of these enzymes are already being studies as potential drug targets; one against Mycobacterium tuberculosis and another against another type of worm.

As the head of McMaster University's antibiotic research center in Hamilton, Ontario, Wright has the most tricked - out laboratory a drug designer could want, complete with a $ 15 million high - speed screening facility for simultaneously testing potential drugs against hundreds of bacterial targets.

One of the greatest challenges in modern medicine is developing drugs that are highly effective against a target, but with minimal toxicity and side - effects to the patient.

The findings could offer scientists a new target for developing drugs against obesity and other appetite - related disorders, the researchers say.

«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»

Drugs that targeted the RAS pathway showed little activity against the tumor cells.

To make a compound work better against a specific disease target, medicinal chemists optimize the drug, tweaking its structure or physical properties to make it more effective and safer.

Wapner's narrative follows developments from the recognition of a chromosomal abnormality in cancer cells to the production of a targeted drug against what had been a lethal leukemia.

The idea is to target microbes at different points in their life cycle, thus minimizing their ability to evolve a defense against a drug and become resistant.

«Drugs with multiple targets show promise against myotonic dystrophy type 1.»

New drugs targeting these pathways may be useful against a variety of different cancers.

Chemogenomics is a new concept where drug design and screening is conducted at the genome level for selective drug discovery effort against one target among a large family of related proteins / receptors.

«The microgravity environment of the International Space Station is now being used for myriad lines of research, for example: vaccine development, finding novel molecular targets against drug - resistant pathogens, and testing of molecules to be used against osteoporosis or cancer,» Zea says.

In contrast to viral proteins, the host targets are less prone to mutations and thus drugs targeting them could be more effective against viruses, which mutate easily.

Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA - approved treatment that affects 200,000 people per year in the United States.

Co-senior study investigator and cancer biologist Iannis Aifantis, PhD, says the study offers the first evidence that «drugs targeting and disrupting leukemia cells» microenvironment — or what goes on around them — could prove effective against the disease.»

Consequently, many research groups are in hot pursuit of finding new drug targets and designing novel ones against the disease.

«Maybe we can design a drug that would specifically target this [novel] chemistry,» says Cross, who notes that the virus's reliance on M2 might make mutating against such a specialized drug difficult.

The first such drug, called ipilimumab (Yervoy), developed out of Allison's basic science research, showed much lower response rates against advanced melanoma than those obtained with targeted drugs, but long - term follow - up found that 22 percent of those treated with Yervoy survived at least four years, unprecedented results for the disease.

«People have been targeting telomerase as a potential cancer therapy for a long time,» he says, noting that anti-telomerase drugs are in phase II clinical trials against several cancers.

The targets of these drugs were not know to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types, says Professor Ivaska.

In theory, drugs targeting CXCR4 would be an effective addition to the arsenal against HIV.

«These exciting results provide new hope for developing drugs against an important molecular target in the brain,» said Roderick Corriveau, program director at the National Institute of Neurological Disorders and Stroke, which helped support the research.

«New drug target can break down cancer's barrier against treatment.»

«Together, our findings indicate that these molecular regulators, TRIP - Br2 and GATA3, could be viable targets for small drug molecules that could serve as potential therapeutic agents against obesity,» Liew said.

Zeitlin says the study may also help researchers find new targets for drugs against Huntington's — such as compounds that block the clumping of abnormal huntingtin.

«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.

If the missing gene somehow protects against disease, then a drug that targets that gene could treat illness without causing side effects.

Antibiotics are impotent against them, and the few drugs targeting a specific virus often lose their efficacy as the pathogen evolves.

The replicon, however, could become «enormously useful» as a target for testing potential drugs against HCV, says Stanley Lemon of the University of Texas Medical Branch at Galveston.

The work should help provide targets for better drugs against S. pneumoniae, which is increasingly becoming resistant to existing therapies, as well as vaccines.

«As drug resistance is a major problem for malaria control and eradication, it is critical that that we continue to develop new antimalarials that act against previously unexploited targets in the parasite to keep priming the drug pipeline.»

Since these proteins serve as «master regulators» for controlling whole gene programs, drugs against these targets could have broader effects than traditional ones that block single enzymes.»

Previous studies had shown that the apicoplast - targeting drugs have a delayed - death effect: They allow the parasite to grow and replicate in the liver, where the immune system can develop antibodies against the invaders.

The findings suggest that drugs targeting this molecule could serve as a new treatment strategy to protect against liver fibrosis.

Previous work at CU Cancer Center shows these drugs are especially useful against lung cancers that over-express both EGFR and HER2, implying that in addition to targeting HER2 - positive lung cancers with drugs approved to treat HER2 - positive breast cancers, there may be a role for HER2 inhibitors in HER2 cancers, perhaps both breast and lung.

The identification of what happens in a rat's brain when it falls off the wagon «gives us a target against which we can work to find appropriate medications to deal with relapse,» says Alan Leshner, director of the National Institute on Drug Abuse in Bethesda, Maryland.

The new process, called Extensive Combinatorial Refinement (ExCoR), could help improve the development of drug candidates that depend to a great degree on detailed structural analysis to determine how they work against specific disease targets.

Preliminary genetic evidence included in the study suggests that the enzyme, called SNRK, performs similar functions in humans, making it an intriguing new drug target in the battle against obesity and its complications.