Sentences with phrase «drug targets because»

Although variations in the NPAS1 and NPAS3 genes have been linked to brain disorders including autism, they aren't obvious drug targets because their function is most important in early life.

«Nobody's ever looked at nutrient transporters as drug targets because it's assumed that there will be hundreds more transporters, so it's a pointless pursuit,» Ahmer said.

However, TrkB was less - than - optimal as a drug target because its activation has both desirable and undesirable consequences.

mTOR is particularly tantalizing as a drug target because the FDA, which regulates which drugs can be used in humans, has already approved some mTOR inhibitors for cancer treatment and in organ transplants.

Not exact matches

Those particular products were important because Target Canada needed to change people's shopping habits and lure them away from Shoppers Drug Mart and Loblaws.

The shares dropped 3.6 percent as the group also cut its 2018 sales target because of lower reimbursement of calcimimetic drugs at its dialysis service business in the United States.

Triple negative breast cancer is especially hard to treat because it lacks the receptors, such as the estrogen receptor, targeted with other cancer drugs.

Because the genes that are massively amplified in the neochromosomes are essential for the cell's survival, drugs that turn those off are an obvious target for research.

«We've been targeting human cells with therapeutics that modulate the way the cell makes lipids, and we like to target the human cell because it isn't likely to mutate and become resistant to the drug.

The gene, called NPC1L1, is of interest because it is the target of the drug ezetimibe, often prescribed to lower cholesterol.

About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).

And customizing the feedback fMRI is generally more difficult than customizing the dose of a drug, because each person might be helped best by targeting a different brain region with a different mental exercise.

The scientists believe the drug targets a stress pathway specific to alcoholics because it has been shown to have little effect on stress levels in other types of patients.

A combination of techniques — from computation to medicinal chemistry — helps scientists pick better drug targets, often because of gaining a better understanding of how diseases work

The company decided to set up the institute, he adds, because it expects to get «a large competitive advantage» if it can efficiently translate genetic information into drug targets.

As an example, Pierce points out that many drugs failed because they could not be effectively delivered to their targets.

This is important because it makes it possible to model almost any autoimmune disease, evaluate new drug therapies, and even identify novel targets in the emerging area of cancer immunotherapies.

This is crucial because therapies, such as cancer drugs, can target histones.

Because the NPTX2 gene is not expressed in normal kidney tissue, a drug designed to target its protein would provide a highly focused treatment, Dr. Copland says.

«PPM1D is itself a target for drug development, because the gene mutation causes cells to avoid death and proliferate,» Yan said.

Developing broad - spectrum drugs for the battlefield has proved difficult because regulators are more accustomed to evaluating drugs that target one specific disease, and drug companies prefer to focus on diseases that affect many people rather than on obscure pathogens that could serve as bioweapons.

Because some of these neighbour proteins are as central and as global as the cancer - related proteins themselves, and link to so many other processes in the cell, there's a strong likelihood that drugs targeting them may have strong side - effects.

Our analysis showed that the drug had no effect when the receptor was absent, presumably because there was no target to bind to.

Despite this high profile, K - Ras has earned a reputation in scientific circles as being «undruggable» because many pharmaceutical, biotech, and academic laboratories have failed to design a drug that successfully targets the mutant gene.

And because the drug isn't very good at binding to its GABA - AT target, patients must take large doses, which in turn can lead to retinal damage.

Nor can his organoids be used to test drugs targeting blood vessels or immune cells because organoids have neither.

«Current antiretroviral drugs target HIV's proteins,» says James Stivers, Ph.D., a professor of pharmacology and molecular sciences at the Johns Hopkins University School of Medicine, «but those proteins are moving targets because they are often altered by mutations.

However, resistance almost always develops because tumors harbor multiple genomic defects capable of driving the disease after a targeted drug knocks down one driver.

However, the reality is that nanocarriers may not always reach their intended target in sufficient numbers because of a constraint on their ability to transit through the blood vessel wall at the tumor site, leading the encapsulated drugs to be diverted or lost before they can deliver their payload.

There's a need for ways to find these cells and to study them, and importantly, to develop drugs that target them, because these cancer stem cells are resistant to chemotherapy drugs that target the main tumor.

Zeroing in on this kinase was encouraging, Goga said, because other researchers have shown that genetic - knockout mice that lack the entire family of PIM kinases are slightly smaller than normal mice, but «basically fine,» indicating that a drug targeting just PIM1 may have manageable levels of toxicity in breast cancer patients.

«Localized signaling islands in cells: New targets for precision drug design: Because their range of action is limited to their immediate vicinity, these messaging stations could be ideal for targeted therapeutics.»

The findings are particularly noteworthy because drugs that act on the newly discovered target, a protein known as PIM1, are already in clinical trials for leukemia and multiple myeloma.

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

Most HIV drugs target viral proteins, but because they often mutate when exposed to antiretroviral agents, resistance can develop quickly.

That's because other APOBEC enzymes cause cancer - related mutations — a kind of «friendly fire» that makes these enzymes a potential target for new drugs.

Chemotherapy drugs tend to target rapidly dividing cells, because fast replication is a hallmark of cancer cells.

Additional genes included in the database could be the focus of future drug development efforts because they belong to classes of genes that are thought to make promising drug targets.

Another 6,700 genes are in the database because they potentially could be targeted with future drugs.

The new drugs, which target the COX - 2 enzyme, were seen as better than traditional painkillers like aspirin because they don't have gastrointestinal side effects.

A potential drug target would have to be found within the cancer - causing pathways activated by Rac1b, since the enzyme is difficult to target because it is involved in many normal biological processes, Dr. Radisky says.

Microtubules are a critical component of the cytoskeleton, vital for cell division and, because of that, an excellent target for chemotherapy drugs.

That raised an intriguing question, because one of the few things scientists already knew about cyclophilin A was that it is the target of a powerful immunosuppressant drug, cyclosporin A.

«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.

Many of these new drugs promise to be more effective because they target key pathways of cancer cells more specifically.

Because IBD is a clinically heterogeneous disease with complex mechanisms, a combination of drugs targeting distinct biomarkers might be considered as a potential approach.

Drugs that target KORs have shown promise as therapeutic candidates because of their efficacy for treating chronic itch and relieving pain.

Drug companies had long ago given up on targeting RAS, however, because it doesn't have an obvious pocket, or binding site, that a drug could fit into to block its activity, says Frank McCormick, who recently stepped down as director of the Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, to spend half his time directing NCI's RAS projDrug companies had long ago given up on targeting RAS, however, because it doesn't have an obvious pocket, or binding site, that a drug could fit into to block its activity, says Frank McCormick, who recently stepped down as director of the Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, to spend half his time directing NCI's RAS projdrug could fit into to block its activity, says Frank McCormick, who recently stepped down as director of the Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, to spend half his time directing NCI's RAS project.

University of California, Berkeley researchers have now found a promising new drug target within that pathway that is appealing, in part, because it appears to control production of only a few percent of the body's many proteins, those critical to regulating the growth and proliferation of cells.

«This is very exciting because we haven't had a new drug for stroke in decades, and this suggests a target for such a drug,» says lead author Dr. Zsuzsanna Fabry, professor of pathology and laboratory medicine.