Sentences with phrase «drug targets in»

We are applying it to evaluate large number of potential drug targets in a faster and more systematic way than before and to select the best ones to work on.

My background was in the identification of drug targets in prostate cancer, so working on developing new therapies in glaucoma was a natural progression.

Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors.

The researchers also are seeking other potential drug targets in the 50 percent of patients who don't have high levels of the anti-death protein, as well as biomarkers in addition to CA125 that could be used to screen for ovarian cancer.

The researchers say there is an urgent need for new drug targets in major depressive disorder.

Other trials of this drug target in lung cancer have not worked, and the drugs» effects in colorectal cancer are also questionable, Stambolic says.

«Acupuncture impacts same biologic pathways in rats that pain drugs target in humans.»

Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA - approved treatment that affects 200,000 people per year in the United States.

«Virtual tissue technology reveals new drug target in polycystic kidney disease: Advanced computer simulations show that failures of cell adhesion and inhibition cause two types of kidney cyst formation.»

TNF is already a drug target in psoriasis.

«If knocking out this other hydrogenase also drastically reduces long - term survival, the enzyme might end up being an excellent next - generation drug target in latent TB infections, which around one - third of the world's population suffer.

In 2009, Stegmaier's laboratory discovered that SYK, a kinase that had attracted attention for its role in other malignancies, could be a potential drug target in AML.

Preliminary genetic evidence included in the study suggests that the enzyme, called SNRK, performs similar functions in humans, making it an intriguing new drug target in the battle against obesity and its complications.

A new PNAS paper from geneticist Tamara Caspary's lab identifies a possible drug target in medulloblastoma, the most common pediatric brain tumor.

Winship Cancer Instituteâ $ ™ s Ned Waller and researchers from Childrenâ $ ™ s Healthcare of Atlanta and Yerkes National Primate Research Center were part of a recent Science Translational Medicine paper that draws a bright red circle around aurora kinase A as a likely drug target in graft - vs - host disease.

Validation of Cyclin D1 / CDK4 as an anticancer drug target in MCF - 7 breast cancer cells: Effect of regulated overexpression of Cyclin D1 and siRNA - mediated inhibition of endogenous Cyclin D1 and CDK4 expression.

Like etnangien, gladiolin was found to inhibit RNA polymerase, a validated drug target in M. tuberculosis.

Researchers identify a new drug target in leukemia and creation of a candidate drug that hits the target...

Not exact matches

The drug targets a wider variety of defence mechanisms used by antibiotic - resistant bacteria and can be used in more situations.

Zymeworks will be putting its two leading drug candidates, both targeted at breast cancer, into clinical trials in the next few months.

US Air Force Major General James Hecker said the A-10s were returning to meet an increased need for close air support in a campaign targeting Taliban revenue sources including drug - producing facilities and in counter-terrorism operations.

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

It's the first time the agency has approved a drug that targets cancer based on a tumor's genetic traits, rather than where it is located in the body.

Mylan No. 2 targeted in massive generic drug price collusion probe.

In a new study based on mice, scientists at Lancaster University found that a drug that goes after three diabetes - related targets «significantly reversed the memory deficit» in mice who got the drug, as measured by their performance in a maze test when compared to mice who didn't get the druIn a new study based on mice, scientists at Lancaster University found that a drug that goes after three diabetes - related targets «significantly reversed the memory deficit» in mice who got the drug, as measured by their performance in a maze test when compared to mice who didn't get the druin mice who got the drug, as measured by their performance in a maze test when compared to mice who didn't get the druin a maze test when compared to mice who didn't get the drug.

The experimental drug targets hormones that are key in regulating the body's blood - sugar levels: GLP - 1, GIP, and glucagon.

Having dealt with Judy's, the next target for McGonigal and his team was the McKesson distribution center, three hours away in Landover, Md., which delivered the bulk of the pharmacy's drugs.

Perepelkin says that failure applied to the pharmacies as well; for example, the Canadian pharmacies didn't carry Target's ClearRX trademark for prescription drug labelling that's been successful in the U.S.

Merck is the latest company to weather bad news in the Alzheimer's drug race, halting a late - stage trial yesterday in an experimental amyloid - targeting candidate called verubecestat after a data monitoring committee said there was «virtually no chance of finding a positive clinical effect,» Reuters reported.

It is also restricted almost entirely to Africa, which, unfortunately for its victims, makes it a less attractive target for big drug companies than a host of non-fatal diseases (think erectile dysfunction) that are more common in rich countries.

One recent example: Stemcentrx, which rode an unproven approach targeting cancer stem cells to a summertime financing round of nearly $ 250 million and a $ 5 billion valuation, the most for a venture - backed drug maker and second to Theranos in health care.

Democratic presidential contender Hillary Clinton, who has made high drug prices a recurring target in her campaign, vowed to prevent price hikes like Mylan's through an «aggressive new set of enforcement tools» last week.

That led to an earlier Food and Drug Administration (FDA) approval for Keytruda than Opdivo in 2014 since the former was a more targeted therapy; but it also left Merck with a smaller slice of the market.

But while the U.S. Food and Drug Administration has approved more than two dozen drugs targeting a range of male sexual matters, pharma has turned a cold shoulder to female dysfunction, despite the prevalence of conditions like hypoactive sexual desire disorder, a chronic disinterest in sex estimated to affect 8 to 14 percent of American women ages 20 to 49.

Lift CEO Matei Olaru said he believes its accounts were targeted in connection with the U.S. tech giants» policies barring promotion of the sale of illegal, prescription or recreational drugs, even though medical marijuana is legal in Canada and recreational pot will soon follow suit.

The 32 - year - old CEO of Turing Pharmaceuticals became a target of widespread ire in September when he boosted the price of the toxoplasmosis treatment Daraprim by over 5,000 % after acquiring the drug in August.

This is far more targeted than the traditional model for drug development, which includes such scattershot methods as screening natural elements like soil from a plateau in Norway and then asking, What might this do?

Several regional grocers fit the traditional profile of an attractive target, but Shoppers Drug Mart stood out as a uniquely strategic asset in a less familiar but complementary space.

For example, CRAC channels in T cells have been clinically validated as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.

Alnylam has been developing drugs that target gene expression in order to prevent to production of certain biological material which can cause devastating diseases.

Cholesterol busters Demos didn't originally see this group as a big target market but changed his mind after the Food and Drug Administration certified in 1999 that soy protein can help fight coronary heart disease.

We saw that there was a risk in selling marijuana, but since drug laws often target both the buyer and the seller, there is also a risk (albeit smaller) to the consumer interested in buying marijuana.

Additional clinical trial data later this year on Tesaro's key drug, Niraparib, which targets advanced solid tumors in ovarian and breast cancers, could help narrow the valuation gap, the people said.

The shares dropped 3.6 percent as the group also cut its 2018 sales target because of lower reimbursement of calcimimetic drugs at its dialysis service business in the United States.

RxAdvance's services are designed to target an $ 840 billion market opportunity, comprised of this $ 370 billion drug benefit, plus $ 120 billion in specialty drug management, plus an additional $ 350 billion market in managing avoidable drug - impacted medical costs.

Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (OM).

To combat the activities of Mexican, Central American, and South American transnational criminal organizations — including illicit finance and money laundering activities and the flow of illegal drugs — the FBI works side - by - side with its numerous domestic and international partners to infiltrate, disrupt, and dismantle these groups by targeting their leadership and using sensitive investigative and intelligence techniques in long - term, proactive investigations.

But it seems everyone from James Clapper, to Louis Lerner, to Eric Holder, Susan Rice etc. etc. seems to be constantly contradicted or exposed as being less than truthful, whether it's IRS Targeting, tapping journalists, blaming Benghazi on a video, the existence of WMDs, a search for yellow - cake Uranium, who ordered Fast and Furious putting automatic guns in the hands of Mexican drug - lords, drone strikes, or... the nature of PRISM.

BERLIN German dialysis specialist Fresenius Medical Care cut its 2018 sales target due to lower than expected doses of calcimimetic drugs at its dialysis service business in the United States.

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.