Sentences with phrase «drug thalidomide»

THE NEWS THESE DAYS is rarely good, but two stories in recent editions of the newspaper were truly shocking: a posse of 15 policemen had stormed the Contemporary Arts Center in Cincinnati and, temporarily, closed down the traveling exhibition «Robert Mapplethorpe: The Perfect Moment»; and further, medical researchers had suggested that the drug thalidomide be reintroduced on the market as an effective therapeutic treatment

Will some ed - tech products come to be viewed in the same way people now view the miracle drug thalidomide?

Most recently, he said it might lead to similar health problems as the drug thalidomide.

The ongoing repurposing of the infamous drug thalidomide may include treatment of Crohn's disease, an incurable bowel condition.

One victory: Gilla Kaplan, now a researcher at the Public Health Institute in Newark, New Jersey, found that the drug thalidomide — banned in 1962 after it was linked to severe birth defects — could reduce inflammatory responses and might be valuable in managing HIV, tuberculosis, cancer, and autoimmune diseases such as lupus.

Scathing of drugs companies and the way they often put profits before human life, he had earlier fought for the rights of victims of the drug thalidomide.

The change came about after a massive scandal surrounding the drug thalidomide, which in the 1950s was widely prescribed to pregnant women to alleviate morning sickness.

Not exact matches

Probably the most infamous teratogen is thalidomide, a tranquilizing, anti-nausea and sleep - inducing drug.

In a new twist of a historic tragedy, 13 Americans who say they are survivors of thalidomide are suing four companies for producing and distributing the notorious drug.

Holmes also notes that the relative paucity of thalidomide births in the United States means that few researchers there can speak with authority on the drug's effects.

Meanwhile, reports of startling birth defects in babies born to mothers who had taken thalidomide were surfacing in Germany, Australia and other countries where the drug was legal — including Kelsey's native Canada.

In July 1962, a detailed story about America's close call with thalidomide appeared on the front page of The Washington Post, under the headline «Heroine of FDA Keeps Bad Drug Off Market,» with a photo of Kelsey.

For example, in its current work, the team showed that the micro-hearts didn't develop properly if exposed to thalidomide, a drug that infamously resulted in birth defects when pregnant women took it to treat morning sickness.

Much like BMS, Celgene also made a big gamble about a decade ago when it developed a class of immune - modulating drugs that included the infamous teratogen thalidomide.

If you look at the original work on the epidemiology of thalidomide [a morning - sickness drug that turned out to cause birth defects], there were specific time points where, if the woman was exposed, the baby had a high probability of having bona fide autism.

The company in - licensed thalidomide in 1992 and received FDA approval to market the drug (as Thalomid) for treating severe cutaneous manifestations of leprosy in 1998 and for treating multiple myeloma in combination with dexamethasone in 2006.

Worldwide, roughly 10,000 affected children nicknamed «thalidomide babies» were born with multiple defects, including the characteristic shortened upper limbs (a condition known as phocomelia, Greek for «seal limbs»), before the drug was discontinued in 1961 after four years on the market.

In both zebrafish and chick embryos, adding a version of cereblon that doesn't bind to thalidomide seemed to blunt the drug's effects.

Toxicologist Craig Harris of the University of Michigan, Ann Arbor, who has studied thalidomide's effects on gene expression, says that the new data are consistent with some theories of the drug's action, however.

To test the potential of the system as a drug - screening tool, the researchers exposed the differentiating cells to thalidomide, a drug known to cause severe birth defects.

When scientists tried to clarify the fatal effects the drug had when taken by pregnant women, they found that only (S)- thalidomide caused birth defects, whereas (R)- thalidomide had the desired calming and anti-nausea effects.

In the late 1950s and early 1960s, doctors prescribed thalidomide as an antinausea drug for pregnant women with a regularity that proved tragic.

«Ultimately, we don't want anyone to be using a drug as hazardous as thalidomide,» she says.

A pilot study of thalidomide, published in 2001, found the drug improved blood counts in some patients and enabled others to become transfusion - independent.

Distinct non-cancer drugs already investigated in clinical cancer trials comprise metformin, aspirin, hydroxychloroquine and thalidomide [3, 4].

While too late to help those whose lives were blighted by the drug during pregnancy, this finding could help rehabilitate thalidomide, which is effective against several serious conditions, including multiple myeloma, a form of cancer.

Like thalidomide and Accutane, statin drugs are a class X drug with regard to pregnancy, meaning they are contraindicated and should NOT be taken by pregnant women.

But the American and European research communities didn't regard randomized field trials as essential until the 1950s, when Jonas Salk discovered the polio vaccine and Sen. Estes Kefauver held hearings on the testing of thalidomide and other drugs.

Restricted drug programs and related prescription - processing requirements (e.g., thalidomide, isotretinoin, clozapine)»»