To build a working knowledge of the regulatory aspects of
drug use in animals and instill a strong sense of ethical responsibility in decision making regarding veterinary drug use.
Not exact matches
Resistance is also fueled by the massive and often inappropriate
use of antibiotics
in agriculture; for decades these precious
drugs have been
used to promote growth and fend off costly infections that can result from the cramped conditions of industrial - scale food
animal production.
Such concern has sparked the launch of the Obama administration's five - year plan to combat antibiotic resistance, as well as the Food and
Drug Administration's new guidelines aiming to restrict antibiotic
use in farm
animal products, like meat and poultry, that make it to our dinner plates.
More sophisticated
use of GM plants and
animals to produce human medicines — dubbed «pharming» — is a new field which promises to deliver
drugs too complex to be synthesised
in the test tube.
For example, the Food and
Drug Administration recently issued guidelines for the industry to voluntarily withdraw medically important antibiotics from
use in animal growth promotion, and several major suppliers have done so.
In view of this it should avoid the
use of fertilizers, pesticides,
animal drugs and food additives that may have adverse health effects.
Carrageenan is such an efficient inflammatory agent and carcinogen, it is widely
used with laboratory
animals to study the molecular signals involved
in cancer and anti-inflammatory
drugs.
In a 1992 article in The North American Review entitled «The Corruption of Nobility: The Rise & Fall of Thoroughbred Racing in America,» Ferraro penned a stinging rebuke against drug abuse on the backstretch, saying, «In general, treatments designed to repair a horse's injuries and to alleviate its suffering are now often used to get the animal out onto the track to compete — to force the animal, like some punch - drunk fighter, to make just one more roun
In a 1992 article
in The North American Review entitled «The Corruption of Nobility: The Rise & Fall of Thoroughbred Racing in America,» Ferraro penned a stinging rebuke against drug abuse on the backstretch, saying, «In general, treatments designed to repair a horse's injuries and to alleviate its suffering are now often used to get the animal out onto the track to compete — to force the animal, like some punch - drunk fighter, to make just one more roun
in The North American Review entitled «The Corruption of Nobility: The Rise & Fall of Thoroughbred Racing
in America,» Ferraro penned a stinging rebuke against drug abuse on the backstretch, saying, «In general, treatments designed to repair a horse's injuries and to alleviate its suffering are now often used to get the animal out onto the track to compete — to force the animal, like some punch - drunk fighter, to make just one more roun
in America,» Ferraro penned a stinging rebuke against
drug abuse on the backstretch, saying, «
In general, treatments designed to repair a horse's injuries and to alleviate its suffering are now often used to get the animal out onto the track to compete — to force the animal, like some punch - drunk fighter, to make just one more roun
In general, treatments designed to repair a horse's injuries and to alleviate its suffering are now often
used to get the
animal out onto the track to compete — to force the
animal, like some punch - drunk fighter, to make just one more round.
Here are some of the excluding criteria most experts agree on: «Obese parents; parents who smoke (either during pregnancy or at present); parents sleeping on a waterbed, recliner, sofa, armchair, couch or bean bag; parents who sleep on multiple pillows, a sagging mattress or a sheepskin or
use heavy bedding, such as comforters or duvets; sleeping
in overheated rooms; parents under the influence of
drugs or alcohol; other children or pets who can or are likely to climb into the bed; and stuffed
animals on the bed that could cover the baby's face.»
The Food and
Drug Administration has long permitted its
use, but
in recent years concerns about the chemical have grown as studies have indicated low doses of the substance can disrupt hormone systems
in laboratory
animals and possibly increase the risk of cancer or other serious illness.
And while the science may be disputed, depending on who is funding the study, as to whether commonly
used food dyes such as Yellow 5, Red 40 and 6 others made from petroleum pose a «rainbow of risks» that include hyperactivity
in children, cancer (
in animal studies), and allergic reactions, because of the problem of hyperactivity, the Center for Science
in the Public Interest petitioned the Food and
Drug Administration to ban the
use of these dyes given that the British government and European Unionhave taken actions that are virtually ending their
use of dyes throughout Europe.
This is something that many nurses and lactation consultants recommend and is present naturally
in vegetables and
animals,
used as an emulsifier
in food,
drug, and cosmetic products.
Researchers at the European Union Reference Laboratory for alternatives to
animal testing developed five different tests that
use human blood cells to detect contaminants
in drugs that cause a potentially dangerous fever response.
Although hormonal growth promoters are illegal
in the UK, it is widely feared that the
use of antibiotics may be contributing towards the development of
drug - resistant bacteria, with potentially serious consequences for
animal and human health.
Studies show that these models can accurately predict the ways that new
drugs will react
in the human body and replace the
use of
animals in exploratory research and many standard
drug tests.
«Autism's social deficits are reversed by an anti-cancer
drug:
Using an epigenetic mechanism, romidepsin restored gene expression and alleviated social deficits
in animal models of autism.»
Because Nanotax is a repurposed form of an already
in -
use drug, it shortened the time between
animal and patient trials.
Wilmut's work is supported by a biotechnology company, PPL Therapeutics
in Edinburgh, which plans to
use the patented cloning technique to produce
animals that will secrete valuable
drugs in their milk.
BPTES has been
used in animal models for a variety of cancers but has not substantially reduced tumor sizes, probably because the
drug concentration
in tumor tissue is not high enough when
using conventional
drug formulation methods, say the scientists.
Using electrophysiology and pharmacological tools, the research has shown that a potassium channel, specifically the BK channel,
in the central nervous system can be regulated with
drugs to increase or decrease these disruptions
in animal models.
Furthermore, there are no differences between the major political party affiliation groups on views about the
use of
animals in research, the safety of eating genetically modified (GM) foods and whether to allow access to experimental
drug treatments before those treatments have been shown to be safe and effective.
Why the
drug combination works
in resistant CML Why such a combination of the two inhibitor types works
in an
animal model has now been explained by Prof. Stephan Grzesiek's team at the Biozentrum of the University of Basel and Dr. Wolfgang Jahnke from Novartis, by a structural analysis
using nuclear magnetic resonance spectroscopy (NMR).
Psychiatric
drugs are also
used in birds, though
animal welfare groups worried that the
use of such
drugs to treat behavioural problems
in animals would create a population of «pill - popping pets».
Now, the researchers have discovered an alternative
in a mouse model:
in the case of breast tumours with a specific defect
in DNA repair, the
animals can be cured
using already established, cheap chemotherapy
drugs, if enough DNA damage can be inflicted on the resting tumour cells.
(Update, 9:26 pm Statement from New Iberia:» Nothing
in the videos alter the fact that the New Iberia Research Center is
in compliance with all federal standards and guidelines regarding the care and
use of
animals, as determined by the U.S. Department of Agriculture, the Food and
Drug Administration, and the Centers for Disease Control.»)
In animal and cell culture studies, the drug inhibited growth both in estrogen - dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cance
In animal and cell culture studies, the
drug inhibited growth both
in estrogen - dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cance
in estrogen - dependent breast cancer cells and
in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cance
in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely
used types of
drugs to prevent and treat estrogen - dependent breast cancer.
Scientists
in other countries are more likely to work with fetal cells
in efforts to modify an
animal's genetic makeup so that its milk contains
drugs for human
use.
Sun is currently conducting collaborative research with hydrogels for applications and efficiency with anticancer
drugs screening and delivery, stem cells and wound healing, as well as being
used in vaccines for H1N1 influenza and
animal diseases, such as the porcine reproductive and respiratory syndrome virus, or PRRS.
«Maybe at the one - cell or two - cell stage,» Eggan and his colleagues reasoned, «there's still some of that stuff
in there...» And if they picked the right moment of cell division, when these powerful reprogramming factors were still floating around
in the periphery of the cell, they might be able to
use drugs to temporarily freeze the cell
in the middle of division, stick
in the needle of a micromanipulator to suck out the embryonic DNA, squirt
in DNA from an adult
animal, and then kick - start the process of reprogramming — hours, perhaps even days after an egg had been fertilized.
In their
animal experiments, the team
used genetic engineering techniques to knock out the DAXX gene, but they want to develop a
drug that can achieve the same result.
In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditio
In a novel
animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment
using a small molecule
drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment
in a mouse model of the neurodegenerative conditio
in a mouse model of the neurodegenerative condition.
In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal mode
In their report that has received advance online publication
in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal mode
in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the
use of light to trigger a chemical reaction — with a molecular therapy
drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy
drug required to suppress tumor progression and metastatic outgrowth
in an animal mode
in an
animal model.
Regardless of whether Landrigan's legal team was simply
using the
drug shortage as stalling tactic, their legal maneuvering brings to the fore a contentious dispute over the science (or some would say lack thereof) behind lethal injection executions
in the U.S.. For more than two decades, it has been argued that the FDA should be required to certify the safety and effectiveness of
drugs used to carry out executions (as it does for
drugs used to euthanize
animals).
In the study, Bruce Hope, from the National Institutes of Health National Institute on Drug Abuse Intramural Research Program in Baltimore, Maryland, and colleagues used animal models to investigate if the brain forms drug - related memories in a similar wa
In the study, Bruce Hope, from the National Institutes of Health National Institute on
Drug Abuse Intramural Research Program in Baltimore, Maryland, and colleagues used animal models to investigate if the brain forms drug - related memories in a similar
Drug Abuse Intramural Research Program
in Baltimore, Maryland, and colleagues used animal models to investigate if the brain forms drug - related memories in a similar wa
in Baltimore, Maryland, and colleagues
used animal models to investigate if the brain forms
drug - related memories in a similar
drug - related memories
in a similar wa
in a similar way.
For the current study, Jessica Childs, a graduate student
in Kroener's lab, applied VNS to a test group of rats
used in the study
in a process called «extinction learning» to determine whether the procedure could help the
animals learn different behaviors and reduce their
drug cravings.
He added that the existence of episodic memory
in lower
animals has implications for research on human diseases that affect memory, including Alzheimer's, Parkinson's and Huntington's diseases, since the majority of research on the brain — and the
drugs used to treat memory diseases and dementia — start out based on insights into how the brain works
in rats.
The researchers examined respondents» deference to science on a scale of 0 - 10 when it came to 14 policy issues, including child vaccinations, stem cell research, global warming, child obesity and diet, AIDS prevention, birth control education, legalizing
drug use, gun control, regulation of nuclear power,
animal testing, and teaching evolution
in schools.
The Italian law would ban
in 2017 the
use of
animals to study
drug abuse research and xenotransplantation.
«Importantly, we
use mice as models of human beings
in research, and so when looking for anti-obesity
drugs, we need to fully understand the function of the NPY system
in this
animal model to understand how similar circuits
in humans connect with the body clock.»
This has led to a demand for people who can understand data collection techniques and analyze vast amounts of data, categorize the data sets, develop models to test hypotheses that can then be
used to develop
drugs, and test potential candidates
in animals.
The study, «Modulating Behavior
in C.elegans
Using Electroshock and Antiepileptic
Drugs,» just published
in PLOS One, has led the researchers to build on the current
animal models for inducing seizures via electroconvulsion
in the genetically modifiable C.elegans that only has 302 brain cells called neurons.
«This work sets the stage for additional
animal studies to see if tamoxifen can be
used as a
drug in people and will allow us to design new
drugs related to tamoxifen that are better antifungals,» says Damian Krysan of the University of Rochester, an author on the study.
Kumamoto University researchers found that
using MCM - 41 as a
drug delivery system for malaria treatment produced a highly efficient treatment
in animals.
Both classes of
drugs are
used in animals and humans.
More
animal studies would be needed to move this
drug toward human clinical trials, but «what we hope is that we could
use this
drug to intervene
in patients who have had an episode of prolonged seizures and give it to them briefly following that episode to protect them from becoming epileptic,» said James McNamara, M.D., a professor
in the departments of neurobiology and neurology at Duke University.
The original aim of the treaty was to ensure that Third World nations would be rewarded if the plants and
animals found within their borders were
used in the development of new
drugs.
CHICAGO (Reuters)-- The sale and distribution of antibiotics approved for
use in food - producing
animals in the United States decreased by 10 percent from 2015 to 2016, a U.S. Food and
Drug Administration (FDA) report said on Thursday.
One particularly worrisome finding, to be published soon
in the Journal of Zoo and Wildlife Medicine, is that treatments with voriconizole, an antifungal
drug often
used in animal care, sometimes kills even apparently healthy snakes.
dispersal of new
drugs in animal studies, among other
uses.
It costs millions of dollars to develop
drugs and get them tested
in animals before they can ever be
used in clinical trials for safety and efficacy
in humans.