Sentences with word «druggable»
The word "druggable" refers to a molecule or target that can be influenced by a drug or medication. It means that it is possible to design a drug or treatment that can interact with and affect that specific molecule or target, leading to a desired therapeutic effect. Full definition
The National Eye Institute has awarded Jackson Laboratory Professor Patsy Nishina, Ph.D., and Associate Professor Gregory Carter, Ph.D., a four - year grant totaling $ 2,414,304 to study diseases of the retinal pigment epithelium (RPE), with the goal of identifying druggable targets for age - related macular degeneration (AMD) and other heritable retinal diseases.
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«Protein identified as potential druggable target for pancreatic cancer.»
«Identifying druggable targets that participate during the pre-symptomatic stage of the disease is particularly important,» Nishina says, «to enable development of therapies that can prevent, delay onset or decrease the severity of RPE - associated diseases irrespective of the initial cause of the disease.»
By getting inside the cell and getting the body to produce intracellular proteins, we have the potential to address many diseases that today aren't druggable with small molecule drugs or biologics.
Manipulation of autophagy is actively being pursued as a potential druggable pathway to treat many of these disorders, some of which are in clinical trials.
The first award will be used to investigate the unexplored parts of the so - called «druggable genome» — genes that have the potential to be used as future therapeutic drug targets.
The discovery, published online today in Cell, illuminates a major shift in understanding anti-tumour mechanisms and identifies a promising druggable target against colorectal cancer stem cells, says principal investigator and lead author Dr. Daniel De Carvalho, a scientist at Princess Margaret Cancer Centre, University Health Network.
In the past several years, for example, they have invented techniques for identifying druggable sites centered on cysteine or serine amino acids on proteins.
The findings from our proposed studies will further define how the RPE supports the photoreceptor functions via metabolic coupling, and hopefully identify novel druggable targets for preventing RPE and retinal degeneration during AMD.
The authors identified 453 potentially druggable events (PDEs) in 59 genes, 3 % of which were germline variants.
After adjusting for relative incidence, 52 % of pediatric tumors had a potential druggable event.
That, in turn will help us develop other, druggable compounds or targets that will help relieve some of these disorders.»
For the new study, the TSRI researchers sought to map druggable sites centered on lysine amino acids.
Various treatment regimens have failed to improve PDAC patient survival, driving the critical need for finding druggable targets essential for tumor maintenance.
Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.
Next the team prioritized 21 drugs for which the yeast druggable targets were involved in the greatest number of cell - lethal interactions.
«We think that a more potent Pin1 inhibitor will be able to target many «dream targets,» that are not currently druggable.
Kinases are also druggable targets, as seen by the success of kinase - inhibitors in earning FDA approval (including, for example, crizotinib against ALK - fusion and erlotinib against EGFR).
Researchers at The Institute of Cancer Research reported in the journal Nature Reviews Drug Discovery (January 2013 issue) that they have found a new way of rapidly prioritizing the best druggable targets online.
The proteins newly revealed to be druggable belong to a variety of functional classes, including enzymes that catalyze biochemical reactions, scaffold proteins that act as hubs for other protein signaling complexes, and transcription factors that regulate gene activity.
Since many of these targets are not enzymes or surface receptoers with readily druggable pockets, these important oncogenic proteins can not be easily inhibited with small molecules.
«This vastly opens up our options for new druggable targets.»
Many of the major cancer - causing gene alterations, such as MYC, TP53, or KRAS, are not directly druggable (2 — 5).
More and more doctors are starting to recognize that the related conditions of the metabolic syndrome which are all closely related to obesity are treatable, not druggable conditions.
«This identifies a promising druggable target against fusion - positive prostate cancer and takes us a step closer to providing personalized cancer medicine for up to 50 % of prostate cancer patients,» he says.
Together, these data revealed a functional link between the ABL kinases and TAZ signaling leading to increased AXL abundance in breast cancer cells, and identified a potentially druggable pathway for the treatment of breast cancer bone metastasis.
Our results reveal a synthetic lethal relationship between the HR pathway and Polθ - mediated repair in EOCs, and identify Polθ as a novel druggable target for cancer therapy.
Our research will contribute to a better mechanistic understanding of the microbes that live in our gut, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.
By pairing engineered cell lines containing disease - specific mutations with high throughput screening, we can investigate the role of given mutations in the biology of disease as well as identify potential druggable targets.
The CRISPR - Cas technology can be used to screen for druggable targets and to develop gene and cell therapies for unmet medical needs.
«If we find some targets that constantly change in the eye with glaucoma, then we may be able to find some small chemicals to target those genes in the eye,» he said of these «druggable» targets.
«We show that the bacteria in the GI contain «druggable targets,» ones that we can modulate with the same types of small molecule approaches that have transformed other aspects of human health.»
«Viral infection in colon cancer stem cells mimicked; druggable target identified.»
The project, in cooperation with GriffithUniversity, has identified more than 700 bioactive compounds with druggable potential.
The researchers first used yeast to quickly and cheaply screen 169,000 interactions between yeast versions of human tumor - suppressor genes and genes that can be inhibited with drugs, sometimes called «druggable» targets.
Gain a deeper understanding of the classification of the human proteome, including the tissue - specific proteome, the house - keeping proteome, and the druggable proteome
«We report the discovery of a new pocket on K - Ras that is druggable.
«Our work paves the way to discovering many more of these unusual RNAs and how they contribute to cancer, which could reveal new mechanisms and druggable pathways involved in tumor progression.»
«I think we've unraveled a pathway to begin to take something that wasn't druggable and make it druggable,» said Eisenstat.
DGIdb — Mining the druggable genome.
«Still, it's exciting that we've found a mechanism that can lead to the disease that is a new, druggable target.
«PHB is a druggable target (targeted by Rocaglamide) and as such, it is hoped that our work paves the way towards an effective treatment able to prevent the neurological complications associated with EV71 infections.»
The key part is finding a biomarker that is druggable.»
But a new study from scientists at Sanford Burnham Prebys Medical Discovery Institute suggests that a key group of transcription factors are in fact «druggable,» including several that could be targeted to treat cancer, metabolic disease, or autoimmune conditions.