Sentences with phrase «drugs affect cells»

Not exact matches

This allows us to reveal how drugs affect heart functions in a scenario where the two cell populations are closely coupled,» said Ben Maoz, Ph.D., a co-first author on the second study, who also is a Technology Development Fellow at the Wyss Institute and a member of Parker's group.

Becoming drug resistant does not appear to affect the ability of the virus to infect cells.

Different drug molecules make it possible to affect the function of these receptors and, consequently, to prevent cell activation and mediator release.

The researchers isolated bacteria from the tumors of pancreatic cancer patients and tested how they affect the sensitivity of pancreatic cancer cells to gemcitabine, a chemotherapy drug.

«Drugs like morphine hijack the body's natural painkilling mechanisms, such as those used by endorphins, but because they act within the central nervous system, they can affect other brain cells that use similar pathways, leading to side effects such as addiction or sleepiness,» says Professor Gamper.

Chemotherapy drugs kill cancer cells, but they also affect the vasculature inside the tumor.

Arguing that «this high degree of complexity both in terms of immunological outcomes and underlying mechanisms, necessitates that HDAC inhibitors be studied in a context that is matched to their intended utility,» Brad Jones, from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Boston, USA, and colleagues set out to test whether the three drugs affected the ability of CTL to eliminate HIV - infected target cells.

I think we will also be able to use stem cells in vitro to screen new drugs and see how they are likely to affect the people taking them, making prescriptions safer and more accurate.

If a given drug cocktail kills 90 percent of the cancer cells but doesn't affect the remaining 10 percent, the resistant tumor cells can take over and cause the tumor to grow back.

Evans - Freke also says that animal studies show that normal functioning of PDGF RTK in healthy cells is not affected by the drug.

Neuroscientist Bryan Kolb, at the Canadian Centre for Behavioural Neuroscience in Lethbridge, Alberta, has explored how brain cells are affected by drugs, hormones, and injury.

Organic synthesis is a scientific discipline central to the drug discovery process that is focused on building new carbon - based molecules that can affect biology — for example, targeting and destroying cancer cells.

Some basic research findings are being translated into new treatments, and with the discovery of induced pluripotent stem cells in 2006, the field has seen a step - change in biological understanding that will affect the way new drugs are identified and tested and, potentially, the way cells can be generated in the lab.

A few years ago, Manalis and colleagues set out to adapt this technique to predict how cancer drugs affect tumor cell growth.

Researchers at MIT have now shown that they can use a new type of measurement to predict how drugs will affect cancer cells taken from multiple - myeloma patients.

Researchers used data from different people's genotypes and metabolism to build personalized models that simulate how a drug will affect a particular set of cells in the body.

In the 1990s the U.S. Food and Drug Administration approved its use in the treatment of both multiple myeloma (a form of cancer that affects plasma cells) and the complications of leprosy.

This is clear from the fact that the third drug in the study, sodium nitroprusside, does not affect endothelial cells, but still produced different effects in the veins of black people and white people.

Researchers led by Nigel Bamford of the University of Washington in Seattle, US, gave mice large doses of methamphetamine, equivalent to those taken by addicts during drug binges, to see how this affected communication between cells in the brain's cortex and those in a region of the brain called the striatum.

Researchers at the La Jolla Institute for Allergy and Immunology, in collaboration with colleagues the University of California, San Diego, identified a novel drug target for the treatment of rheumatoid arthritis that focuses on the cells that are directly responsible for the cartilage damage in affected joints.

The ability to recapitulate both the affected neural cells and the blood - brain barrier, according to Shusta and Svendsen, provides detailed insight that not only reveals the mechanics of the syndrome, but also raises the possibility of identifying drugs that may help overcome the diminished ability of the hormone to nurture the developing brain.

Therefore, identification of molecules that affect both parasites during their release from infected host cells not only highlights robustness of the complementary screening approach we adopted, but also conserved drug targets for pan anti-parasitic drug development,» Dr Dhanasekaran Shanmugam from NCL added.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

Forcing the cells to organize and stretch into three - dimensional tissue helps spur development and coaxes them into resembling more mature cells that can better predict how a drug will affect adult heart cells.

As such, these cells are inadequate for drug testing because they do not properly predict how a drug will affect adult heart cells.

A trained robotic surgeon experienced in the treatment of prostate, bladder and kidney cancer, Assoc Prof Chia said, «For anticancer drugs to achieve their best effectiveness, they need to penetrate into the tumour efficiently in order to reach the cystoplasm of all the cancer cells that are being targeted without affecting the normal cells.

He thinks a number of cancer cell subsets are never really affected by most targeted anticancer drugs currently used.

Although drugs to block the PD - 1 pathway have been developed for cancer patients, they affect all immune cells, not just HIV - specific ones.

In order to test possible treatment strategies, the scientists placed the affected cells into a three - dimensional cell culture and examined the drugs's effect ex vivo, so to speak.

Unlike many chemotherapeutic drugs that affect healthy cells as well as malignant ones and can cause undesired side effects, the control of lncRNAs may offer a new way to specifically prevent or slow the progression of malignant cells.

In today's issue of Science Translational Medicine, he and his colleagues present a more efficient way of finding such new uses for old drugs: by bringing together data on how diseases and drugs affect the activity of the roughly 30,000 genes in a human cell.

The same drugs hardly affected the survival of cells in rest of the tumor.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

A study led by scientists from Harvard Medical School reveals «hidden» variability in how tumor cells are affected by anticancer drugs, offering new insights on why patients with the same form of cancer can have different responses to a drug.

«For many years, the focus has been on finding drugs that block channels and receptors in the brain that affect the way signals are made between cells.

Moreover, the team used the technique to shed light on how three different invasion - inhibiting drugs affect interactions between the parasites and red blood cells.

Simon's strategy is to compare the effects of a drug on a normal strain of yeast and a strain with a mutation in one of the many genes that affect normal cell division - a property that is disrupted in cancerous cells.

While most chemotherapy drugs kill all rapidly dividing cells in the body, causing serious side effects which limit their use, a drug that inhibits telomerase would only affect those cells that are immortal and malignant.

Immunotherapy drugs contain antibodies that affect the way the immune system is activated allowing the immune system to identify and destroy cancer cells.

Almost every mechanism of cancer cells tested was reported to be affected by these drugs, a phenomenon hardly to be traceable back to one or a few underlying molecular targets.

In the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.»

We looked at the different molecular and cell properties they had, how different drugs affected each — essentially comparing and contrasting the two cell types.

Such drugs would selectively affect leukemia cells, because they are so dependent on heme.

JJ Miranda, PhD, reported that certain drugs affect genes in tumor cells infected with the Epstein - Barr Virus.

In a study published in the journal Biochemical and Biophysical Research Communications, a team led by Miranda examined how certain drugs affect genes in EBV - infected tumor cells.

Insofar as kinase inhibitors interfere with signaling dynamics, and, in turn, signaling dynamics affects inhibitor responses, we investigated associations in this study between cell - specific dynamic signaling pathways and drug sensitivity.

The work at the ESRF will help CRELUX / WuXi AppTec to support their clients in the discovery and development of novel and more specific drugs that can influence AMPK activity in the cell and, as a result, adjust the energy balance in disease affected organs.

Our platform is designed to emulate human biology more accurately than current cell culture or animal models, and we are currently working with a diverse group of partners to test the way drugs, foods, and chemicals affect human health.

Basic research presentations at 2016 American Heart Association Scientific Sessions: cell therapy for heart attack (mesenchymal stem cells) in animal models and role of CD73, gradual release drug for atrial fibrillation, how particles from stored blood affects blood vessels.

In a new study from the Howard Hughes Medical Institute in Boston, researchers exposed human cells to a group of commonly used antibiotics including ciprofloxacin, ampicillin, and kanamycin and observed how these drugs affected the mitochondria of these cells.