Sentences with phrase «drugs against cancer»
But most people — scientists included — are astonished to realize that most of our antibiotics to combat infections, chemotherapy drugs against cancer, psychotropic drugs which modify mood disorders, and many advances in cardiovascular treatments and procedures were stumbled upon.
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Our results can contribute to the development of new drugs against cancer stem cells but, unfortunately, it takes a long time to get from basic research to usable drugs,» says Stina Oredsson.
Not exact matches
SOUTH SAN FRANCISCO, Calif. — February 5, 2018 — FLX Bio, Inc., a biopharmaceutical company focused on the discovery and development of oral small molecule drugs to activate the immune system against cancer, today announced the appointment of senior pharmaceutical research and development executive Michael F. Giordano, M.D., to its Board of Directors.
ZURICH (Reuters)- Roche's Tecentriq immuno - oncology drug failed a late - stage follow - up trial against advanced bladder cancer, the Swiss drugmaker said on Wednesday, raising questions about whether regulators could scale back their approval of the medicine.
Roche, the world's biggest maker of cancer drugs, had won fast - track approval last May in the United States for Tecentriq against bladder cancer but full approval hinged on further trials.
The IMvigor211 study had been meant to confirm a previous trial, called IMvigor210, that was central to the U.S. Food and Drug Administration's accelerated approval last year of Tecentriq against bladder cancer.
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One is working to create new weapons against cancer, while the other is working to ensure drugs that enter the market do not bring dangerous unintended consequences.
The company has begun human testing of its mRNA drugs for cardiovascular disease and cancer, and for vaccines against the flu, Zika, and chikungunya viruses.
The FDA recently okayed the first therapeutic cancer vaccine, and other drugs that enlist the immune system against tumors are under study
If similar genes are found in people, drugs that mimic their protective effects could be a better strategy against cancer and ageing than simply mopping up all free radicals (PLoS Genetics, DOI: 10.1371 / journal.pgen.1000488).
A drug that releases two gases to protect the stomach lining may be significantly more effective than daily aspirin in protecting against cancer
The researchers tested the drug combinations against four different human cervical cancer cell lines.
Drugs That Ramp Up the Immune System against Tumor Cells are Revolutionizing Cancer Treatment
The researchers also identified drugs that are effective against the cancers and could potentially be used in the fight to save the devils from extinction.
«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»
The findings, reported in today's issue of Science, * offer a promising new avenue for testing drugs against EBV, which has also been implicated in sinus and throat cancer.
Wapner's narrative follows developments from the recognition of a chromosomal abnormality in cancer cells to the production of a targeted drug against what had been a lethal leukemia.
The researchers showed how gelsolin works at the molecular level to protect cancer cells against a widely used chemotherapy drug called cisplatin.
Initially used to protect against side - effects such as fractures, there is also some evidence that taking the drug extends the lives of women with breast cancer.
Phase I / II clinical trial results reported at the American Society for Clinical Oncology (ASCO) Annual Meeting 2015 show promising results for investigational drug brigatinib against ALK + non-small cell lung cancer (NSCLC), with 58 of 78 ALK + patients responding to treatment, including 50 of 70 patients who had progressed after previous treatment with crizotinib, the first licensed ALK inhibitor.
New drugs targeting these pathways may be useful against a variety of different cancers.
Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.
Some compounds of the dozens of variations the scientists created exhibit potent cytotoxicities against certain cancer cells, including a drug - resistant cell line, Nicolaou said.
Checkpoint inhibitors already produce unprecedented rates of long - term remission for a handful of hard - to - treat cancers, but their potential is even greater: Because such drugs modify the body's response to cancer, rather than the cancer itself, they could theoretically be effective against almost any kind of malignancy.
«The microgravity environment of the International Space Station is now being used for myriad lines of research, for example: vaccine development, finding novel molecular targets against drug - resistant pathogens, and testing of molecules to be used against osteoporosis or cancer,» Zea says.
Co-senior study investigator and cancer biologist Iannis Aifantis, PhD, says the study offers the first evidence that «drugs targeting and disrupting leukemia cells» microenvironment — or what goes on around them — could prove effective against the disease.»
Once again, researchers at Penn's Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.
For example, the study defined cases of pancreatic cancer that are driven by a gene called BRAF, for which there are FDA - approved drugs, and showed that such drugs were selectively effective against BRAF - mutated pancreatic cancer cells.
In research published in BioMetals, UJ3 is shown to be as effective against human esophageal cancer cells, as a widely - used chemotherapy drug in use today.
This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.
«Nanoparticles combine photodynamic and molecular therapies against pancreatic cancer: Novel drug - delivery system cuts off common treatment escape pathways in animal models.»
They hope the drug will do artificially what the genetic defect in Laron syndrome does naturally: protect against DNA damage that fuels cancer growth.
Along with the drug types mentioned above, other categories that blocked viral entry included estrogen receptor modulators used against cancer and serotonin reuptake inhibitors used to treat depression.
«People have been targeting telomerase as a potential cancer therapy for a long time,» he says, noting that anti-telomerase drugs are in phase II clinical trials against several cancers.
It also opens the door to predicting which drugs will work against breast cancer that has already spread.
Drug - smuggling nanoparticles could be the latest recruits in the fight against cancer.
Because it more effectively induces cancer cell apoptosis in p53 - deficient tumors, FL118 is especially effective against late - stage cancers, which usually lose functional p53 and are resistant to DNA - damage drugs.
- Identification of anti-hypertension drugs as potential therapeutics against breast and pancreatic cancer metastasis was a big surprise.
The targets of these drugs were not know to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types, says Professor Ivaska.
Paradoxically, some drugs that disable Hsp90 have shown promise against cancer, by stopping the cancer from building proteins it needs to survive.
Spain's top cancer scientist is fighting with the government over a plan to use private funding to develop drugs against lung cancer — and both parties have chosen the media as their battleground.
«We wanted to identify new genes that are worthy of creating drugs against in cancer treatment,» says Beronja.
Earlier this month, NBCC's outspoken president, attorney Fran Visco, sounded off against approving the drug Avastin for breast cancer, arguing that «it does not show clinical benefit.»
«This is the first example of taking a genetic sequence and designing a drug candidate that works effectively in an animal model against triple negative breast cancer,» said TSRI Professor Matthew Disney.
Interferon - a, a drug widely used to treat hepatitis C and several cancers, may also work against SARS, according to a study published online this week by Nature Medicine.
«New drug target can break down cancer's barrier against treatment.»
Obesity is associated with increased inflammation, which could improve the effectiveness of checkpoint blockade drugs that unleash an immune response against cancer.
«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.
They also showed that drugs against a type of breast tumor called HER2 positive breast cancer — such as the dual ERBB2 / EGFR inhibitor lapatinib — potentially could benefit more patients than currently receive them, if analysis of the tumor proteins is taken into consideration.