Not exact matches
Antiviral
drugs amantadine and rimantadine, which for years were the most widely used
against influenza A viruses, plugged the M2 pathway like bathtub stoppers, preventing reproduction.
The researchers said that identifying this virus sensor, called ZBP1, offers the hope of developing
drugs to protect
against influenza's sometimes lethal complication of pneumonia.
In an ambitious study, the authors attempt to trace
drug resistance
against all strains of the flu by using an extensive
influenza virus database containing all known genetic sequence information (70,000 complete nucleotide sequences) for
influenza strains.
The transmissible viruses were sensitive to the antiviral
drug oseltamivir and reacted well with antisera raised
against H5
influenza vaccine strains.
«Researchers synthesize active molecules
against drug - resistant mutants of
influenza A virus.»
Moreover, the team led by Santiago Vázquez has adequately modified the polycyclic structure to prepare compounds with high antiviral activity, including
against several
drug - resistant mutants of
influenza A virus.
«But since these
drugs inhibit all prostanoids, each may contribute differently towards the immunity
against influenza virus,» says Francois Coulombe, a McGill Ph.D. student and the study's first author.
In the search for
drugs that act broadly
against different
influenza strains, researchers had previously shown that antibodies
against the HA stem region can prevent
influenza infection.
But Markovitz and his co-senior author Hashim M. Al - Hashimi, Ph.D., professor of biochemistry at Duke University and formerly professor of chemistry and biophysics at U-M, hope that their team's work can help address the lack of antiviral
drugs that work well
against many viruses or
against viruses that change rapidly, such as
influenza.