Sentences with phrase «drugs against the virus»

We are making efforts to apply these findings in the development of drugs against viruses such as human parainfluenza virus,» Professor Sakaguchi described.

Not exact matches

Here's some of what's going on in the health care world as we head into Easter weekend: payers are pushing back against PTC Therapeutcics» controversial Duchenne muscular dystropy drug; insurers are cautiously lauding new rules for Obamacare's marketplaces; a fascinating lawsuit in Arkansas explores the ethics of drug making; and a new test for Zika virus can produce results within an hour.

The company has begun human testing of its mRNA drugs for cardiovascular disease and cancer, and for vaccines against the flu, Zika, and chikungunya viruses.

«It's certainly within the realm of possibility that if peroxisomes play this key role in antiviral defense, it may be possible to take drugs that are known to boost peroxisome production to provide protection against the viruses,» says Hobman.

Understanding this critical step of Zika virus replication will help researchers develop antiretroviral drugs against this spreading disease afflicting the entire globe.

Some drugs that block neuraminidase, which helps the virus escape already infected cells, are starting to bump up against viral resistance.

Yet he stresses that these mouse models give insights into pathogenesis and will allow for high - throughput screening of drugs and vaccines against the virus.

This also included a virus isolate resistant against most available drugs.

They are helping researchers study how drugs work against the swine flu virus and how space and time warp around colliding black holes.

Researchers at the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children's Hospital and Houston Methodist have developed an alternative treatment in which virus - specific cells protect patients against severe, drug - resistant viral infections.

Made into a permanent programme in 2009, it set out to sequence the genomes of potential bioterror agents, explore new drug technologies and develop «broad - spectrum» therapies that would work against multiple bacterial and viral pathogens — especially haemorrhagic fever viruses such as Ebola and Marburg.

Still, the TMT and the Army awarded the company a $ 291 - million, six - year contract last year to fund two clinical trials, for its drugs against Ebola and Marburg viruses.

In May 2009, he awarded a contract to AVI BioPharma of Bothell, Washington, to make a flu drug against the H1N1 virus, using its genetic sequence as a basis.

In contrast to viral proteins, the host targets are less prone to mutations and thus drugs targeting them could be more effective against viruses, which mutate easily.

An experimental drug that shuts down construction of virus - making factories could become a new weapon against MERS and similar respiratory diseases.

Antiviral drugs amantadine and rimantadine, which for years were the most widely used against influenza A viruses, plugged the M2 pathway like bathtub stoppers, preventing reproduction.

«This drug was not developed as an alternative to vaccination but rather as an additional weapon in our arsenal against the virus that may enable us to improve disease management and rapidly silence outbreaks,» he says.

Cross and his team are screening drug compounds against the virus but have yet to identify serious candidates.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

«Maybe we can design a drug that would specifically target this [novel] chemistry,» says Cross, who notes that the virus's reliance on M2 might make mutating against such a specialized drug difficult.

«We need to do everything we can to find effective drugs against the Zika virus, as changes in travel and climate have caused more tropical diseases to move into new parts of the globe,» said Kao, who has also spent 15 years studying the virus that causes hepatitis C.

«Drugs approved to treat hepatitis C and compounds in development to treat other viral diseases are prime candidates to use against the Zika virus,» Kao said.

Viruses are notorious for evading man - made drugs, but they are powerless against a rare mutation in the gene ISG15.

LONDON (Reuters)-- Researchers announced the launch of two big studies in Africa on Thursday to test a new HIV vaccine and a long - acting injectable drug, fuelling hopes for better ways to protect against the virus that causes AIDS.

Most disconcerting, recent «dual resistance» viruses dodge both drugs, leaving us defenseless against the virus.

The researchers said that identifying this virus sensor, called ZBP1, offers the hope of developing drugs to protect against influenza's sometimes lethal complication of pneumonia.

In an ambitious study, the authors attempt to trace drug resistance against all strains of the flu by using an extensive influenza virus database containing all known genetic sequence information (70,000 complete nucleotide sequences) for influenza strains.

One anticoagulant that Geisbert helped test against the virus was greeted with great enthusiasm when he presented results 7 years ago, because it was the first time a drug had much impact — and yet it only reduced deaths in monkeys by one - third.

To make things worse, no antiviral drugs currently available have proven effective against it, and because scientists do not know where the virus resides between outbreaks, environmental control is impossible.

It can be a serious, life - altering and even fatal disease and currently, there is no cure or drug treatment against West Nile virus, which has been widely spread across the U.S., Canada, Latin America and the Caribbean.

It's even possible to screen drugs against multiple viruses at the same time.

The drug, an enzyme called adenosine deaminase, or ADA, ultimately may be able to activate the immune system against HIV and to help the immune system «remember» the virus to prevent or quickly eliminate future infection.

By taking away materials viruses need to survive rather than attacking them from the outside, the technique might be more useful against a wider range of viruses, and for a longer time, than any one drug.

Antibiotics are impotent against them, and the few drugs targeting a specific virus often lose their efficacy as the pathogen evolves.

The transmissible viruses were sensitive to the antiviral drug oseltamivir and reacted well with antisera raised against H5 influenza vaccine strains.

«Repurposed drug found to be effective against Zika virus: Researchers say findings support further investigation as potential treatment for Zika - infected adults.»

«Researchers synthesize active molecules against drug - resistant mutants of influenza A virus.»

Members of this class of drugs are usually highly specific against components of a particular virus, and mutations in the virus that change these components can make them ineffective.

Moreover, the team led by Santiago Vázquez has adequately modified the polycyclic structure to prepare compounds with high antiviral activity, including against several drug - resistant mutants of influenza A virus.

The drug works by inhibiting replication of the hepatitis C virus; researchers noted that both hepatitis C and Zika belong to the same viral family and bore strong structural similarities that could make sofosbuvir effective against the latter.

«But since these drugs inhibit all prostanoids, each may contribute differently towards the immunity against influenza virus,» says Francois Coulombe, a McGill Ph.D. student and the study's first author.

«To date, neither antiviral drugs nor vaccines are approved for clinical use against human parainfluenza virus, which reinforces the urgent need for new therapeutic discovery strategies.

Later phases of the project will confirm efficacy against live Ebola virus, determine how the drug candidates block the viral machinery and develop additional tests to identify drug candidates that will inhibit not only Ebola virus, but also the related Marburg virus.

Drugs that do exist work against just a few types of viruses.

While an effective vaccine against the virus has been developed and will likely be approved, there are no drugs available to treat Ebola infections.

But Markovitz and his co-senior author Hashim M. Al - Hashimi, Ph.D., professor of biochemistry at Duke University and formerly professor of chemistry and biophysics at U-M, hope that their team's work can help address the lack of antiviral drugs that work well against many viruses or against viruses that change rapidly, such as influenza.

This and other virus surface changes help explain why clinical rhinovirus drug trials, which rely on different virus surfaces, have generally failed when tested against rhinovirus C isolates over the last four to five years, says Palmenberg.

The findings are published this week in the Proceedings of the National Academy of Sciences (PNAS) and provide the foundation for future antiviral drug and vaccine development against the virus, rhinovirus C.

Viral infections kill millions of people worldwide every year, but currently available antiviral drugs are limited in that they mostly act against one or a small handful of related viruses....

«It also was effective against known drug - resistant strains of the HIV virus, making it a very promising candidate for further development into a new HIV drug.»