Sentences with phrase «drugs by the nanoparticle»

iRGD is therefore potentially useful to optimize the delivery of cancer drugs by the nanoparticle to the tumor.

Not exact matches

Phase I funding — which allows up to $ 250,000 for an academic idea, such as decoding the genetic sequence of a protein or studying targeted drug delivery by using magnetic nanoparticles — is available from federal funding and foundations.

• Oculis, an Iceland - based developer of a solubilizing nanoparticle drug delivery platform, has raised an undisclosed amount of Series A funding co-led by Brunner Ventures and Silfuberg.

And by absorbing the same light that triggers the drug release, the gold nanoparticles could also heat the cancer cells, providing a double punch.

While researchers have long worked with nanoparticles for drug delivery, the findings put forth by He and his team represent a crucial breakthrough in addressing multidrug resistance in cancer cells.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

The authors conclude «in summary, the development of chitosan nanoparticles loaded with current trypanocidal drugs coated by a specific nanobody against trypanosomes can reduce the minimal curative dose of these drugs, enhancing their efficacy, minimizing the toxicity and circumventing resistance mechanisms caused by mutations in surface transporters.»

Eventually scientists may be able to «force feed» cells with whatever they want, such as drugs or nanoparticles that are not actively taken up by cells.

And a few different techniques have since emerged to improve drug delivery, and, by extension, safety — such as Alnylam's approach of binding the RNAi therapeutic to a lipid nanoparticle, or fat, to help it settle in the liver.

By synthesizing a nanoparticle that releases its siRNA cargo only after it enters targeted cells, Dr. Tariq M. Rana and colleagues showed in mice that they could deliver drugs that silenced the genes they wanted.

The research team tested the TaOx / SiO2 core / shell nanoparticle (TSN) glue and found that it is clearly visualized by real - time imaging modalities and exhibits adhesive properties similar to that of the U.S. Food and Drug Administration (FDA)- approved cyanoacrylate and Lipiodol (CA - Lp), a mixture of a tissue adhesive and radiopaque oil used in the clinical practice.

He is hoping to have U.S. Food and Drug Administration — approved equipment in place by the middle of 2009 to produce these nanoparticles and move into clinical trials shortly thereafter.

A new study shows that a 70 - year - old malaria drug can block immune cells in the liver so nanoparticles can arrive at their intended tumor site, overcoming a significant hurdle of targeted drug delivery, according to a team of researchers led by Houston Methodist.

Even in nanomedicine, which is one of the best new methods for delivering drugs to a tumor, only about one percent of a dose of nanoparticles will successfully arrive at the intended tumor site, while the rest are filtered out by the immune cells of the liver and spleen.

Nanoparticles capable of delivering drugs to specifically targeted cancer cells have been created by a group of researchers from China.

Prior studies suggested that nanoparticle drug delivery might improve the therapeutic response to anticancer drugs and allow the simultaneous monitoring of drug uptake by tumors.

It's the result of an effort by Paula Hammond, who heads MIT's chemical engineering department, to perfect a process of layer - by - layer assembly that enables nanoparticles to carry several drugs between their strata.

«We can attach different drugs to the nanoparticles, and by changing the chemistry of the bond linking the drug to the nanoparticle, we can alter the release rate of the drug to be faster or slower,» says Andrew Clark, a graduate student in Davis's lab and the study's first author.

The modular nature of Hammond's nanoparticles might also benefit either Belcher's light - responsive nanotubes or Bhatia's fragment - shedding nanosensors, by packing them into a layered particle that contains a chemo drug at its core.

Research Paper Placenta - specific drug delivery by trophoblast - targeted nanoparticles in mice Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan Theranostics 2018; 8 (10): 2765 - 2781.

Using nanoparticles, Yale researchers have developed a drug - delivery system that could reduce organ transplant complications by hiding the donated tissue from the recipient's immune system....

By making use of nanoparticle - based carriers, researchers at North Carolina State University are able to transport multiple drugs into cancerous cells optimally and precisely, in maneuvers that any field commander would be proud of.

Farokhzad and colleagues have considerable expertise with bench - to - bedside translation of nanotechnologies for medical applications, and foundational work done in part by his team has led to the development and first in human testing of a targeted nanoparticle capable of controlling drug release for treatment of cancers, and the first in human testing of a targeted nanoparticle vaccine capable of orchestrating an immune response to facilitate smoking cessation and relapse prevention.

A new, nanoparticle - based drug delivery system being developed by health physics professor Steen Madsen offers new treatment for glioblastoma.