Sentences with phrase «drugs gefitinib»

In tests on EGFR - dependent lung cancer cell lines, Tan and colleagues show that the drugs gefitinib and bosutinib «showed additive and synergistic effects.»

They also analysed the patients» cancers for mutations in two other molecules, one called EGFR which is the target of existing drugs gefitinib and erlotinib, and another called KRAS.

The VA - UAB team says, based on its lab studies, that honokiol binds more strongly with EGFR than does the drug gefitinib (sold as Iressa), which is commonly used to treat head and neck cancers.

Not exact matches

Sure enough, when the team gave the drugs erlotinib and gefitinib to flies, they were more likely to be knocked out by alcohol.

For example, epidermal growth factor (EGFR) mutations may result in sensitivity to drugs that are EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib or gefitinib, whereas individuals with the EGFR T790M mutation are more resistant to these drugs.

The lung cancer drug — called gefitinib — helps by blocking a protein that is known to encourage cell growth, and which was found to be present in high levels at the site of ectopic pregnancies.

Tan and colleagues asked what are these kinases that allow lung cancer to evade gefitinib, and what other drug might turn them off.

Drugs such as gefitinib and erlotinib are supposed to block those growth signals in lung cancer cells, but not every cancer responds to them.

P values for RIPK inhibitor treated vs. MDP (no drug) were < 0.0001 (inhibitor 1), 0.06 (inhibitor 2), < 0.006 (gefitinib), 0.0002 (regorafenib), and 0.0008 (ponatinib).