The MDR1 (multi-drug resistance - 1) gene is responsible for the production of P - glycoprotein, which is normally responsible for transporting certain
drugs out of the brain.
Not exact matches
«If they could figure
out a way to streamline, it would be a lot better,» said Kim Janda, a professor
of chemistry at the Scripps Research Institute in La Jolla, California, who leads a team
of researchers developing a vaccine that would prevent fentanyl overdoses by keeping the
drug from reaching the
brain.
Any number
of drugs can affect the
brain into thinking that you are «floating up
out of the body».
The release
of beta - endorphins and oxytocin into the
brain is a docu «mented fact when people pray, sing, chant, repeat phrases, meditate etc. (It also happens when you exercise... however working
out is a FAR more productive way to get your
brain drugs than religion.
For another thing, all it takes is two working
brain cells to find
out the basics
of drug prohibition pros and cons - you don't need to be a political scientist, OR an economist or sociologist.
To find
out, scientists gave volunteers a single dose
of amphetamine, a
drug that gets the dopamine flowing, and then looked at their
brains.
He is chairman
of the department
of anesthesiology at Hackensack University Medical Center in New Jersey, and he points
out that an anesthesiologist creates
brain - dead patients every day: «We give
drugs to make them die.
Richard Rogers
of the Pennington Biomedical Research Center at Louisiana State University and colleagues used a
drug called fluorocitrate to knock
out the function
of certain astrocytes and neurons in the
brains of rats, blocking the sensation
of hunger.
By combining super-fine electrodes and tiny amounts
of a very specific
drug, Duke University researchers have singled
out a circuit in mouse
brains and taken control
of it to dial an animal's mood up and down.
By combining super-fine electrodes and tiny amounts
of a very specific
drug, researchers have singled
out a circuit in mouse
brains and taken control
of it to dial an animal's mood up and down.
«If modifying cholesterol levels in the
brain early in life turns
out to reduce amyloid deposits late in life, we could potentially make a significant difference in reducing the prevalence
of Alzheimer's, a goal
of an enormous amount
of research and
drug development effort.»
A study
out of none other than the University
of Cambridge found the same engagement
of several
brain areas — all involved in reward and motivation — in people with compulsive sexual behavior as previously found in people struggling with
drug addiction.
He added that the existence
of episodic memory in lower animals has implications for research on human diseases that affect memory, including Alzheimer's, Parkinson's and Huntington's diseases, since the majority
of research on the
brain — and the
drugs used to treat memory diseases and dementia — start
out based on insights into how the
brain works in rats.
«Perhaps giving a person the right dose, at just the right time,
of a
drug with just the right pharmacokinetic properties so its effect will wear off at the right time would work a lot better than bombarding the
brain with benzodiazepines, such as Valium, that knock
out the entire
brain.»
Ishmael said even if coibamide A itself can not enter the
brain or turns
out to have adverse side effects, knowing its structure and mechanism
of action can help researchers develop new
drugs that mimic coibamide A's effects.
This nearly impenetrable lining in the capillaries
of the
brain keeps
out viruses and other bad guys, but it also denies entry to many potential
drugs and other treatments.
Researchers at University
of Florida Health have discovered the mechanics
of how dopamine transports into and
out of brain cells, a finding that could someday lead to more effective treatment
of drug addictions and neurological disorders such as Parkinson's disease.
The research was carried
out at Tel Aviv University and the University
of California - San Francisco and will continue, with a focus on obtaining a better understanding
of the
brain and the biological mechanisms that underlie memory processes that cause vulnerability to alcoholism — and perhaps
drug use — in some individuals.
Circumventing this barrier — specifically designed to keep substances
out of the
brain — is a crucial step for the delivery
of drugs to the central nervous system (CNS).
To find
out whether an oral form
of minoxidil can remodel the vessel's wall to reduce blood vessel stiffness and enhance blood flow to the
brain, researchers studied the
drug's effects in mice.
In two separate grants from the White House's
BRAIN Initiative, Bruchas and his colleagues at the University of Illinois and University of California - San Diego hope that by doing this they can find out which parts of the brain should be targeted for new drugs, and whether light could play a role in treatments for conditions like anxiety, depression, or chronic
BRAIN Initiative, Bruchas and his colleagues at the University
of Illinois and University
of California - San Diego hope that by doing this they can find
out which parts
of the
brain should be targeted for new drugs, and whether light could play a role in treatments for conditions like anxiety, depression, or chronic
brain should be targeted for new
drugs, and whether light could play a role in treatments for conditions like anxiety, depression, or chronic pain.
Delivering
drugs to the
brain is complicated because the three - pound organ is shielded by a complex network
of blood vessels, called the blood -
brain barrier, that keeps
out foreign substances.
1992 - 7 — We carry
out the first clinical trials
of temozolomide, showing how this
drug could help some patients with
brain tumours.
The
drug - treated mice also exhibited deficits in prepulse inhibition, a form
of startle plasticity thought to measure the
brain's ability to filter
out intrusive thoughts, which plague OCD patients.
As Dr. Hyman notes, «the real question that manipulating
brain chemicals with
drugs begs is never asked... Why are those chemicals
out of balance in the first place and how do we get them back to their natural state
of balance?»
Although the focus
of the review is
drug - based interventions for finding solutions to food addictions, the mechanisms
of food addiction is nicely spelled
out: neurotransmitter or
brain chemical imbalances.
Developed in the 1920's to improve
brain function in epileptic children, it fell
out of popularity when anticonvulsant
drugs hit the market.
Sweet foods are rewarding, stimulating the
brain's reward pathways and, via learning and conditioning mechanisms, increasing the likelihood
of seeking
out more sugar, just like the incentive that draws people to
drugs like alcohol, nicotine and cocaine.
«Lucy» is ordinary as a gangster story, exceptional in its special effects, but ultimately serving no realistic point since a
drug that increases our
brain power — such a chemical may indeed be in our future — may give us 4.0 averages in college but will not likely be able to talk the bullets
out of a gun.
Though the
drug culture spoof included inspired moments
of Kids lunacy, particularly Thompson's spectacular «coming
out» musical number,
Brain Candy failed at the box office and the Kids disbanded.
Cut to Jang's luxury suite, where Lucy is forced to reveal the possibly dangerous contents, which turn
out to be bags
of a synthetic
drug capable
of boosting
brain function.
As Jack flips between worlds, the sickening draw
of Marbury becomes like a
drug, hollowing him
out as an inner voice screams: «Freddie Horvath did something to your
brain and you better get help, Jack.»
This gene encodes a protein, P - glycoprotein that is responsible for pumping many
drugs and other toxins
out of the
brain.
The problem for some dogs and Ivermectin (and many other
drugs for that matter) is that some dogs have a gene mutation that doesn't allow for the proper absorption
of these chemicals in and
out of the
brain.
(since the
drug affects your memory prior to taking it) If I hadn't been SO shaken and trying to rack my
brains to figure
out what happened instead
of just reporting it when the
drugs might had system but I felt I lost TOO much vital time AND was too ashamed and afraid that I somehow had done something to deserve it to report it.
KEY ACHIEVEMENTS • Successfully rehabilitated a patient who was suffering from altered
brain activity due to
drug abuse • Implemented a core mental health plan, which successfully treated a family suffering from mass hysteria • Intervened in a crises situation involving a 10 year old child threatening to jump off a third floor apartment and managed to talk him
out of it • Formulated a system which dynamically measured the effectiveness
of each mental health treatment plan and provided suggestions for improvement