The divergent evolution of
a duplicated gene results in genetic incompatibilities between strains of the plant Arabidopsis.
Not exact matches
This mutated
gene copy was also
duplicated in the cancer genome,
resulting in elevated expression.
One
result stood out in the DNA of the people who were less at risk for malaria: Two
genes that provide instructions for two proteins called glycophorin A and glycophorin B were snipped, fused together and
duplicated.
Twin
genes or
duplicated regulatory regions
result, and although one in the pair usually has to keep doing its original job, the other is free to mutate and take on new roles that can enhance an organism's survival.
As the authors note, «the presence of
duplicated and diverged genomic regions probably promotes functional novelty between
resulting gene copies, following positive selection.»
More recently, however, it has become appreciated that after
gene duplication, the
resulting duplicates are often «subfunctionalized» and accumulate complementary mutations: the two
genes together perform the function formerly carried out by a single ancestral
gene.