Sentences with phrase «durable remissions in»

The cytokines interleukin - 2 (IL - 2) and interferon - alpha cause kidney cancers to shrink in approximately 10 % -20 % of patients, and provide durable remissions in a subset of these patients.

This award supports our on - going work developing genetically re-directed T cells to provide complete and durable remission in dogs with B cell lymphoma.»

Not exact matches

Better understanding of how immune tolerance is lost and regained could inform efforts toward establishing stronger and more durable phases of remission in autoimmune disease and toward preventing cancer recurrence.

Fifteen of 19 (79 %) vaccinated dogs in Group 2 eventually relapsed, but 4 dogs (21 %) did not and achieved a durable (> 16 months) first remission after chemotherapy and CD40 - B vaccination.

Ten of the vaccinated dogs (52.6 %) have died due to lymphoma; six remain alive in durable first or second remission, and 3 were euthanized due to other causes.

In the unvaccinated Group 3, 39 of 46 dogs (84 %) that relapsed were treated with salvage chemotherapy and one dog received prednisone alone; however, only 3 (7.7 %) of the dogs in Group 3 that received salvage therapy achieved a durable second remission, compared to 40 % of vaccinated dogs that achieved a durable second remission to salvage therapy, a difference that was statistically significant (p = 0.025In the unvaccinated Group 3, 39 of 46 dogs (84 %) that relapsed were treated with salvage chemotherapy and one dog received prednisone alone; however, only 3 (7.7 %) of the dogs in Group 3 that received salvage therapy achieved a durable second remission, compared to 40 % of vaccinated dogs that achieved a durable second remission to salvage therapy, a difference that was statistically significant (p = 0.025in Group 3 that received salvage therapy achieved a durable second remission, compared to 40 % of vaccinated dogs that achieved a durable second remission to salvage therapy, a difference that was statistically significant (p = 0.025).

Ten of the 15 vaccinated dogs (66.7 %) in Group 2 that relapsed were treated with cyclophosphamide, vincristine, and prednisone (COP) as salvage therapy and four of these dogs (40 %) achieved durable second clinical remission (> 22 months) and did not relapse.