Sentences with phrase «durable responses»
The phrase "durable responses" refers to a positive and long-lasting reaction or outcome to a particular situation, treatment, or event. It means that whatever is being addressed or experienced has a lasting effect and is effective over an extended period of time. Full definition
We know we can get durable responses lasting a decade or more with a few cancers.
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A recent study showed that T - VEC in combination with ipilimumab resulted in an overall response rate of 50 %, durable response rate of 44 %, and tolerable safety profile in patients with advanced melanoma, said Georgina Long, BSc, PhD, MBBS, of the Melanoma Institute Australia in Sydney.
Immunotherapy using checkpoint inhibitors has changed the way we treat several aggressive cancers such as melanoma, non-small cell lung and head & neck cancers, among others, with durable responses achieved in the metastatic setting.
Relapsed or refractory chronic lymphocytic leukemia and acute lymphoblastic leukemia patients have shown durable responses of almost 2 years to a novel T - cell engineering technique developed at the University of Pennsylvania Perelman School of Medicine in Philadelphia.
Immunotherapies such as anti-PD-1 and anti-CTLA-4 have shown durable responses in metastatic melanoma.
Dr. Ribas: We obviously knew that the immune system could lead to durable responses in patients with cancer and you could model it in animal models.
«By contrast, durable responses lasting many years can be achieved with immunotherapy,» said Dr. Hammers.
[11] As immunotherapy is the only form of therapy known to produce durable responses, it remains a viable option for select patients.
The combination of an intratumoral injection of CVA21 and ipilimumab has demonstrated durable response with minimal toxicity in patients with advanced melanoma.
In particular, I have initiated a team approach that is identifying and studying recurrent, treatment - refractory cancers in our clinics using these approaches as a component of evidence - based diagnostic medicine, seeking to better understand the genomic drivers in these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responses.
«Immunotherapy harnesses the immune system to generate durable responses and is better tolerated than chemotherapy.
[13] Durable response (complete or partial), the primary endpoint, was defined as a response lasting continuously for at least 6 months and begun within 12 months of initiation of therapy.
«Even in the era of immunotherapy, there are not large numbers of metastatic NSCLC patients with durable responses to systemic therapy.
A phase II study (ACE - LY - 004) reported in The Lancet by Michael Wang, MD, of The University of Texas MD Anderson Cancer Center, and colleagues showed durable responses...
«The impressive and durable response of the single patient with follicular lymphoma on the phase I trial of this agent spoke to its potential in this disease,» Westin added.
«Brain involvement in DLBCL carries a grave prognosis, and the ability to induce a complete and durable response with conventional therapies is rare,» explains Jeremy Abramson, MD, of the MGH Cancer Center, lead author of the letter in the Aug. 24 NEJM.
«The field was mired by the delivery problem — that is, getting the compounds to the right tissues, and right cell types — and get a durable response.
«Blocking PD1 and PDL1 can result in striking and durable responses, with global overall response rates of 20 % to 25 % as monotherapy in metastatic non-small-cell lung cancer,» Soria says.
«The durable responses we have observed with CTL019 therapy are unprecedented.»
Today, we could be facing another paradigm shift with the use of injectable engineered cells as therapies: treatments that promise transformative, durable responses or even cures.
All five responders had a durable complete response, bringing the durable response rate (objective responses lasting at least 24 weeks) to 21.7 %.
A clinical trial testing T - VEC versus GM - CSF showed the durable response rate was 16 % in patients who received at least one dose of T - VEC, and 2 % in the GM - CSF arm.
But actually, different anti-PD-1 and anti-PD-L1 antibodies are equally giving unprecedented levels of durable responses.
Durable response, commonly referred to as DR, is the length of time that a patient experiences a complete or partial response as a result of treatment.
This team has achieved durable responses to treatment, with a treatment vaccine they developed.
The durable response rate (DRR) in the intention - to - treat analysis was 2.1 % in the GM - CSF arm and 16.3 % in the T - VEC arm, a treatment difference of 14.1 % (95 % CI, 8.2 % — 19.2 %; P <.0001).
To date, the only approved intralesional therapy for metastatic melanoma is talimogene laherparepvec (T - VEC), which has been shown to have a durable response not only in injected dermal, subcutaneous, and lymph node metastases, but also in noninjected regional metastases.