Sentences with phrase «durable responses in»

Immunotherapies such as anti-PD-1 and anti-CTLA-4 have shown durable responses in metastatic melanoma.

Not exact matches

Cancer immunotherapy can produce durable clinical responses, but only in a subset of patients.

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»

«Even in the era of immunotherapy, there are not large numbers of metastatic NSCLC patients with durable responses to systemic therapy.

In future, it may be possible to measure BCR - ABL levels in individual cells in the clinic — this will help us identify the resistant high BCR - ABL cells and better understand how patients develop resistance to imatinib treatment with the aim of combatting this resistance to make response more durable and the treatment more effective.&raquIn future, it may be possible to measure BCR - ABL levels in individual cells in the clinic — this will help us identify the resistant high BCR - ABL cells and better understand how patients develop resistance to imatinib treatment with the aim of combatting this resistance to make response more durable and the treatment more effective.&raquin individual cells in the clinic — this will help us identify the resistant high BCR - ABL cells and better understand how patients develop resistance to imatinib treatment with the aim of combatting this resistance to make response more durable and the treatment more effective.&raquin the clinic — this will help us identify the resistant high BCR - ABL cells and better understand how patients develop resistance to imatinib treatment with the aim of combatting this resistance to make response more durable and the treatment more effective.»

These latter two cell types can mount effective immune responses to viruses and tumors; whereas, exhausted T cells fail and memory T cells, in particular, for long - lasting durable effects.

Using a novel technique to genetically modify T cells for adoptive transfer, Carl June, Michael Kalos, David Porter, Bruce Levine, and colleagues at the University of Pennsylvania School of Medicine achieve clinical responses in patients with chronic lymphocytic leukemia, including two complete, durable (one year) clinical responses, accompanied by in vivo expansion and long - term functional persistence of gene - modified cells.

Immunotherapy using checkpoint inhibitors has changed the way we treat several aggressive cancers such as melanoma, non-small cell lung and head & neck cancers, among others, with durable responses achieved in the metastatic setting.

Relapsed or refractory chronic lymphocytic leukemia and acute lymphoblastic leukemia patients have shown durable responses of almost 2 years to a novel T - cell engineering technique developed at the University of Pennsylvania Perelman School of Medicine in Philadelphia.

«The impressive and durable response of the single patient with follicular lymphoma on the phase I trial of this agent spoke to its potential in this disease,» Westin added.

Somaiah called the ASPS responses «significant and durable,» and noted that the cohort is now still open for enrollment in order to confirm these results.

In an interview, one of the co-authors, Courtney DiNardo, MD, of the University of Texas MD Anderson Cancer Center in Houston, said, «Not only are we seeing responses to these agents, but we are also seeing durable improvements in long - term patient survivaIn an interview, one of the co-authors, Courtney DiNardo, MD, of the University of Texas MD Anderson Cancer Center in Houston, said, «Not only are we seeing responses to these agents, but we are also seeing durable improvements in long - term patient survivain Houston, said, «Not only are we seeing responses to these agents, but we are also seeing durable improvements in long - term patient survivain long - term patient survival.

In 2011, Carl H. June, M.D. (a CRI clinical investigator and member of the CRI Scientific Advisory Council), Michael Kalos, Ph.D. (a former CRI postdoctoral fellow and member of the CRI Scientific Advisory Council), and colleagues at the University of Pennsylvania School of Medicine achieved good clinical responses in patients with chronic lymphocytic leukemia (CLL), including two complete, durable clinical responseIn 2011, Carl H. June, M.D. (a CRI clinical investigator and member of the CRI Scientific Advisory Council), Michael Kalos, Ph.D. (a former CRI postdoctoral fellow and member of the CRI Scientific Advisory Council), and colleagues at the University of Pennsylvania School of Medicine achieved good clinical responses in patients with chronic lymphocytic leukemia (CLL), including two complete, durable clinical responsein patients with chronic lymphocytic leukemia (CLL), including two complete, durable clinical responses.

In particular, I have initiated a team approach that is identifying and studying recurrent, treatment - refractory cancers in our clinics using these approaches as a component of evidence - based diagnostic medicine, seeking to better understand the genomic drivers in these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responseIn particular, I have initiated a team approach that is identifying and studying recurrent, treatment - refractory cancers in our clinics using these approaches as a component of evidence - based diagnostic medicine, seeking to better understand the genomic drivers in these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responsein our clinics using these approaches as a component of evidence - based diagnostic medicine, seeking to better understand the genomic drivers in these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responsein these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responsein hopes of obtaining durable responses.

A phase II study (ACE - LY - 004) reported in The Lancet by Michael Wang, MD, of The University of Texas MD Anderson Cancer Center, and colleagues showed durable responses...

«Although only a small subset of women responded to the drug, pembrolizumab worked extremely well in that subset and responses were durable,» Dr. Adams adds.

Details of a first - in - human case report showed that a patient with melanoma was able to achieve a durable complete response with the combination of two types of immunotherapy.

A recent study showed that T - VEC in combination with ipilimumab resulted in an overall response rate of 50 %, durable response rate of 44 %, and tolerable safety profile in patients with advanced melanoma, said Georgina Long, BSc, PhD, MBBS, of the Melanoma Institute Australia in Sydney.

LED lamps also offer near - instant response, giving valuable extra warning time for following traffic - LED Cargo Box and Side Mirror Lighting: Advanced, powerful yet efficient LED lighting brightly lights the cargo box and job site after the sun goes down with minimal battery drain compared to standard headlights or plug - in lights - Hidden Cargo Ramps: Lightweight, durable loading ramps stowed below the cargo box can be quickly removed and set up to assist with loading wheeled items into the bed — from landscaping equipment to dirt bikes

Designed in cooperation with switch manufacturer Omron, they are optimized for fast response times and should be durable for 50 million clicks.

The devices themselves were met with a mostly positive response from both critics and consumers alike, offering a broad range of fitness tracking capabilities in durable packages with premium designs.