Sentences with phrase «durable responses of»

Relapsed or refractory chronic lymphocytic leukemia and acute lymphoblastic leukemia patients have shown durable responses of almost 2 years to a novel T - cell engineering technique developed at the University of Pennsylvania Perelman School of Medicine in Philadelphia.

«The impressive and durable response of the single patient with follicular lymphoma on the phase I trial of this agent spoke to its potential in this disease,» Westin added.

Not exact matches

Cancer immunotherapy can produce durable clinical responses, but only in a subset of patients.

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»

«Even in the era of immunotherapy, there are not large numbers of metastatic NSCLC patients with durable responses to systemic therapy.

Of the 42 patients receiving the higher dosage, 36 percent experienced durable reponses, including two who had complete remissions and two more whose remissions also were high quality (known as very good partial responses).

«Although only a small subset of women responded to the drug, within that subset pembrolizumab worked extremely well and responses were durable,» Adams adds.

«Anti-PD1 immunotherapy is effective for many, but not all, melanoma patients and responses aren't always durable,» said Jennifer Wargo, M.D., associate professor of Melanoma Medical Oncology.

In future, it may be possible to measure BCR - ABL levels in individual cells in the clinic — this will help us identify the resistant high BCR - ABL cells and better understand how patients develop resistance to imatinib treatment with the aim of combatting this resistance to make response more durable and the treatment more effective.»

One of these patients has stable disease and the other has a durable confirmed partial response.

Using a novel technique to genetically modify T cells for adoptive transfer, Carl June, Michael Kalos, David Porter, Bruce Levine, and colleagues at the University of Pennsylvania School of Medicine achieve clinical responses in patients with chronic lymphocytic leukemia, including two complete, durable (one year) clinical responses, accompanied by in vivo expansion and long - term functional persistence of gene - modified cells.

Although, Immune checkpoint blockade (ICB) has elicited durable therapeutic responses across a number of cancer types, its...

Dr. Chodon's current research focus is to determine factors that enhance the development of re-engineered peripheral blood derived stem cells into efficient anti-tumor immune cells, with ability to recognize and kill cancer cells and persist for durable clinical responses.

Of these patients, 1 achieved a durable complete response (95 weeks), 1 achieved a durable partial response (53 weeks), 1 had a transient partial response, and 3 had stable disease at the conclusion of the triaOf these patients, 1 achieved a durable complete response (95 weeks), 1 achieved a durable partial response (53 weeks), 1 had a transient partial response, and 3 had stable disease at the conclusion of the triaof the trial.

Today, we could be facing another paradigm shift with the use of injectable engineered cells as therapies: treatments that promise transformative, durable responses or even cures.

«The study is remarkable for the fact that four of seven patients with relapsed refractory HL had objective clinical responses, including durable complete responses of more than 4 years.

In an interview, one of the co-authors, Courtney DiNardo, MD, of the University of Texas MD Anderson Cancer Center in Houston, said, «Not only are we seeing responses to these agents, but we are also seeing durable improvements in long - term patient survival.

In 2011, Carl H. June, M.D. (a CRI clinical investigator and member of the CRI Scientific Advisory Council), Michael Kalos, Ph.D. (a former CRI postdoctoral fellow and member of the CRI Scientific Advisory Council), and colleagues at the University of Pennsylvania School of Medicine achieved good clinical responses in patients with chronic lymphocytic leukemia (CLL), including two complete, durable clinical responses.

But actually, different anti-PD-1 and anti-PD-L1 antibodies are equally giving unprecedented levels of durable responses.

In particular, I have initiated a team approach that is identifying and studying recurrent, treatment - refractory cancers in our clinics using these approaches as a component of evidence - based diagnostic medicine, seeking to better understand the genomic drivers in these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responses.

Another proposed study will compare different doses of protein and a different adjuvant developed to try to induce higher and more durable antibody responses.

Durable response, commonly referred to as DR, is the length of time that a patient experiences a complete or partial response as a result of treatment.

To achieve its mission, the Project is developing a Bioinformatics Hub as an open - source, multidisciplinary effort with the overarching goal of providing an enabling infrastructure to support the data processing, analysis and knowledge extraction procedures required to translate high throughput, high complexity human immunology research data into biomedical knowledge, to determine the core principles driving specific and durable protective immune responses.

A phase II study (ACE - LY - 004) reported in The Lancet by Michael Wang, MD, of The University of Texas MD Anderson Cancer Center, and colleagues showed durable responses...

«Although only a small subset of women responded to the drug, pembrolizumab worked extremely well in that subset and responses were durable,» Dr. Adams adds.

Details of a first - in - human case report showed that a patient with melanoma was able to achieve a durable complete response with the combination of two types of immunotherapy.

Macrophages are among the first layer of defense when pathogens invade the body, and their rapid response helps to prime our immune system for a secondary, durable immune response that is specifically targeted to the offending pathogens or cancer cells.

[13] Durable response (complete or partial), the primary endpoint, was defined as a response lasting continuously for at least 6 months and begun within 12 months of initiation of therapy.

A recent study showed that T - VEC in combination with ipilimumab resulted in an overall response rate of 50 %, durable response rate of 44 %, and tolerable safety profile in patients with advanced melanoma, said Georgina Long, BSc, PhD, MBBS, of the Melanoma Institute Australia in Sydney.

But I also know that the early two - and four - year studies on the growing number of people who have had progression - free survival suggest that our responses have been generally durable.

Evaluating the Social Optimality of Durable Public Good Provision using the Housing Price Response to Public Investment ∗

Dogs treated with CCNU showed complete response and two of those responses were relatively durable (7 and 15 months).

Why does «same as it ever was» keep coming to mind when examining the responses of America's elected «leaders» to durable challenges — whether confronting deficits and the debt, the glaring lack of alternatives to oil and the risks posed by unabated emissions of greenhouse gases.

I'm focusing this post not only on his peripatetic nature, but also his willingness to directly engage with anyone — diplomatically or ferociously as the need arose — to convey the science pointing to substantial risks ahead, amid durable uncertainty, and to explain his view of possible responses.

The devices themselves were met with a mostly positive response from both critics and consumers alike, offering a broad range of fitness tracking capabilities in durable packages with premium designs.