Sentences with phrase «duration risks in»

Return on equity should continue to grow over the next three to five years, especially as the company expands its reinsurance portfolio to take on longer - duration risks in an effort to spur results.

Fixed - income investors should consider evaluating the duration risk in their portfolios.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Indeed, this duration of couchification is the most telling aspect of the study: Those who got up more frequently — presumably, even to stand and fetch the cable remote... or a glass of water in the kitchen, let us hope — were less at risk.

Duration, the most commonly used measure of bond risk, quantifies the effect of changes in interest rates on the price of a bond or bond portfolio.

Given that I think curve flattening may continue in 2018 — I am somewhat more comfortable with duration risk than credit risk, at least in the United States.

Collins has adopted a more defensive position in the last 18 months, reducing duration and credit risk by scaling back overweight positions in high - yield and municipal bonds, but he's sticking with allocations to intermediate term funds.

Specifically, longer - duration bonds are reasserting their role as an effective ballast to equity risk and can be especially helpful in equity - centric portfolios.

In fact, if you don't hold bonds to maturity, you may experience similar interest - rate risk as a comparable - duration bond fund.

In this case, I think what muni investors seek is a manager who knows how to conduct deep credit research, adjust for duration and monitor the market for risks and opportunities.

If you are a prodigious saver, are willing to keep your money safe for a set duration of time while earning an interest rate above the current risk free rate 10 Year Treasury, and are concurrently investing in other more aggressive instruments, I recommend diversifying your capital into a 5 - year CD account or longer duration.

We recommend that you diversify your portfolio by placing bids in different loans, with different risk bands and loan durations, to try to reduce risk by limiting your exposure to any one loan.

«While shortening the duration of a TIPS exposure results in a lower yield, the chart below shows it still provides an attractive breakeven ratio, or yield received for the amount of risk that an investor takes.

Lesson 3: Duration and Interest Rate Risk — Since interest rates affect bond prices, one of the biggest risks when investing in bonds is that interest rates will move higher, causing the value of your bonds to lose value.

Former Fed Governor Stein highlighted that Federal Reserve's monetary policy transmission mechanism works through the «recruitment channel,» in such way that investors are «enlisted» to achieve central bank objectives by taking higher credit risks, or to rebalance portfolio by buying longer - term bonds (thus taking on higher duration risk) to seek higher yield when faced with diminished returns from safe assets.

As yields have fallen, duration, or rate sensitivity, has risen, meaning that the risk associated with a change in rates has generally risen for most bond benchmarks and traditional funds.

That different outlook is captured in the figure nearby highlighting how the downside risks to bonds — in this case looking at short duration bonds — is masked in an era of zero interest rate policy but is revealed when the Fed begins raising rates.

The world is VASTLY more leveraged today than it was in the 1980s or even the early 2000s, so any rise in rates (duration) is going to wound risk assets rather quickly.

This is the process by which we put our research to work using the levers of credit risk and duration to make money in the bond market and to stabilize returns over the cycle.

It's not just about reducing interest - rate risk and duration, it's about sticking to what you are trying to achieve in your overall portfolio.

And in the emerging markets (EM), FX (foreign exchange) expressions now offer a similar yield as the EM - DM (developed market) yield spread, without any duration risk, on the back of recent stellar EM spread performance.

We are watching all of this play out real - time as fixed - income fund flows are broadly shunning sectors with embedded credit and / or duration risks, in favor of freshly attractive, and lower risk, high - carry assets.

IGIH provides exposure investment - grade, US - dollar - denominated corporate bonds while minimizing interest - rate risk by shorting U.S. Treasurys that match in terms of duration.

In this explainer on duration, Matt talks about some of the risks and opportunities in a potentially rising interest rate environmenIn this explainer on duration, Matt talks about some of the risks and opportunities in a potentially rising interest rate environmenin a potentially rising interest rate environment.

Organizing such a productive effort, planning its duration in time, making sure that it corresponds in a positive way to the demands which it must satisfy, and taking the necessary risks — all this too is a source of wealth in today's society.

You want to trade him when demand is at its highest (in other words, when competitive teams panic) but you also need to move him before the foot issue returns, unless you're willing to risk keeping him for the duration of his contract.

If we honest about it for much of 2017 he was Sh ** We need more CM partnership options in a season duration — reliance upon ramsey to have the impact he showed 3 or 4 seasons ago is a risk.

Longer duration of breastfeeding may or may not affect the appearance of your breasts, but it will reduce the risk for breast cancer over your lifetime, in addition to the many other health benefits to you and to your breastfed baby.

Taking the present - day levels of contaminants in Norwegian breastmilk and the long duration of breastfeeding (12 months) in Norway into account, the Norwegian Scientific Committee for Food Safety concludes that contaminants poses a low risk to Norwegian infants, and that the benefits of breastmilk to Norwegian infants clearly outweigh the risk presented by contaminants.

The study showed that breastfeeding is associated with about a 10 percent lower risk of several major cardiovascular diseases in later life among Chinese women, and breastfeeding duration seemed to play a role.

As a clinical expert in the management of breastfeeding and human lactation, the IBCLC is trained to counsel mothers and families on initiation, exclusivity, and duration of breastfeeding, and to assist amidst any difficul ¬ ties or high - risk situations.

Most studies have revealed protective effects of breastfeeding on common infections in the first 8 to12 months of life.8, 27,29,30 One study, which distinguished between infectious diseases until and from the age of 6 months, revealed results similar to those from our study.24 Although the authors used exclusive breastfeeding for 3 months as the reference group, exclusive breastfeeding for 6 months reduced the risk of gastrointestinal tract infections between the ages of 3 and 6 months but not between the ages of 6 and 12 months.24 We can not explain why breastfeeding duration was only associated with lower risks of lower respiratory tract infection from 7 to 12 months.

Duration of breastfeeding and risk of infectious diseases in the first year of life.

However, the organization also called for more research regarding the benefits of 6 vs 4 months of exclusive breastfeeding.25 Thus far, several studies in industrialized countries revealed that a shorter duration of breastfeeding increases the risk of common infectious diseases, such as respiratory and gastrointestinal tract infections.8, 19,24,26, — , 32 However, in these studies, various definitions of the exclusiveness of breastfeeding were used24, 27,28,30 or the combination of duration and exclusiveness of breastfeeding was not taken into account.8, 31

These findings agree with the results of a British retrospective study demonstrating an increased duration of gestation with increasing coital frequency at all gestational ages up through 37 weeks.8 Similarly, low - risk women delivering prematurely in another study were less likely to be sexually active than the full - term controls.10

Research published in Pediatrics found that women who were suffering from postpartum depression had an increased risk of a negative breastfeeding experience, including decreased breastfeeding duration, increased difficulties while nursing, and a mother's confidence in breastfeeding.

It is important to note that duration of breastfeeding, the longer a mother breastfeeds in her life (one or more babies and the collective number of months), significantly impacts her risk for breast cancer; the protective effect of lactation on breast cancer risk is cumulative.

The intake of such supplementary fluids is associated in young infants with an increased risk of disease and a shortening of the duration of breast - feeding.

In a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RAIn a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RAin the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RA).

Conversely, many researchers have observed a greater risk of overweight in children and adolescents who had not been breastfed compared with those who had16, 17 or who were breastfed a shorter rather than longer duration.18 — 25 On the basis of a review of 11 studies, Dewey26 concluded that «the evidence to date suggests that breastfeeding reduces the risk of child overweight to a moderate extent.»

Given the length and duration that a woman spends in labor, epidurals have proven to be a very beneficial pain management approach, outweighing the potential risks associated with them.

Research has found that women's breast cancer risk declines in inverse proportion to the duration of breastfeeding: That is, the longer you breastfeed your baby, the lower your risk for developing breast cancer.

Confirming findings from studies conducted outside the United States, this study demonstrated an approximate 1.5-fold increase in the risk of shortened breastfeeding duration in the pacifier group.

Breastfeeding is associated with about 10 % lower maternal risk of several major cardiovascular diseases (CVDs) in later life, and the magnitude of the inverse association was stronger among those with a longer duration of breastfeeding, according to a large, prospective, observational study among Chinese women.

If the umbilical cord becomes compressed during pregnancy or during labor, the risk of damage is determined by the duration of time in which the umbilical cord was compressed.

The risk jumps sevenfold for a first - time mother and tenfold in pregnancies over 41 weeks in duration.

In adjusted analysis a shorter duration of predominant breast feeding (less than two months) was a risk factor for four or more hospital, doctor, or clinic visits because of upper respiratory tract infections (OR 1.43, 95 % 1.02 to 2.01, p = 0.041), as was partial breast feeding for less than six months (OR 1.46, 95 % CI 1.07 to 2.00, p = 0.018).

A recent study indicates long duration of lactation (at least 24 months) is associated with a reduced risk of heart disease in women.

In conclusion, findings from this meta - analysis suggest that breastfeeding, particularly a longer duration of breastfeeding, was inversely associated with risk of EOC.

However, when duration of breastfeeding was examined, children who had breastfed for longer than six months had a 43 % reduction in risk for AML and a 28 % reduction in risk for ALL [13].