Sentences with phrase «during brain development»

It's dangerous to assume that findings in adults can be mapped onto children, she says, because of the changes that occur during brain development.

The scientists also found that children with congenital heart disease carry large numbers of mutations in genes that are active during brain development.

These included sites involved in regulating gene activity during brain development and initiating the transcription of genes.

DNA sequences were once thought to be identical from cell to cell, but it's increasingly understood that mutations can arise during brain development that affect only certain groups of brain cells.

Does variation in sleep during brain development influence adult brain organization?

Together, these specialized proteins are believed to help neurons grow during brain development.

Another provocative observation from the new study was that transient gene expression events during brain development set up broad distinctions in neural fate between cells in different areas in the cerebral cortex.

The group investigated the ability of human neural cells to aid the formation of blood vessels during brain development.

The article discusses how trauma can alter a child's neural processing abilities during brain development and the potential effects abuse or neglect during childhood has on arrest rates later in life.

«In individuals with the disability, the enzyme is not produced in sufficient quantity, and the resulting asparagine depletion affects the proliferation and survival of cells during brain development.»

This is a unique scientific paradigm: the first publication determining the role of human - specific gene duplications during brain development came out of our laboratory recently (Charrier et al., 2012) and represents a milestone in our understanding of the genetic and neurobiological mechanisms underlying the emergence of human - specific traits of brain development, for example neoteny during synaptic maturation (Benavides - Piccione et al., 2002; Petanjek et al., 2011).

Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during brain development in zebrafish, and went on to show that the human versions of these RNAs can substitute for the zebrafish lincRNAs.

It also allows «lineage tracing,» showing when during brain development the mutations arise and how they spread through brain tissue as the mutated cells grow, replicate and migrate, carrying the mutation with them.

So, the new findings support the idea that genetic differences expressed early during brain development may have a lot to do with the development of bipolar disorder symptoms — and other mental health conditions that arise later in life, especially in the teen and young adult years.

Like children, puppies have a small window of time during brain development when they are most impressionable.

In the Lu laboratory, we aim to elucidate the signaling cascades that establish neural circuit connections during brain development, to understand how sensory experiences and environmental factors affect neural circuit wiring and cognitive behaviors, and to identify novel factors required to maintain the health of neural circuits during aging.

Changes in lipidome composition during brain development in humans, chimpanzees, and macaque monkeys.

A joint study conducted by Travis Stracker and Jens Lüders indicates that the protein CEP63 plays a key role during brain development as it is involved in the correct division of stem cells in this organ.

Patricia Garcez examines the cellular and molecular effects of Zika virus congenital syndrome during brain development.

The team says it is not clear whether the unwanted connections are indispensable stepping stones or routine «overshoots» but the discovery may throw new light on diseases thought to result from misconnections during brain development, such as autism.

In a paper published this month in the journal Molecular Psychiatry, researchers at the University of California San Diego School of Medicine, with colleagues across the nation and world, have created a «mini-brain» model, derived from persons with a particular form of idiopathic ASD characterized by over-sized brains, revealing a defective molecular pathway during brain development that results in early neuronal overgrowth and dysfunctional cortical networks.

Current research addresses how disrupted endocannabinoid signaling during brain development primes for delayed neuropsychiatric illness.

«The immune system during brain development works like an orchestra,» he says.

As such, it can help researchers observe changes in synapses during brain development and disease.

NRXN1 and CNTN6 are important during brain development and produce molecules that help brain cells form connections with one another.

They found that two specific genes, DLX1 and DLX2, regulate GABA synthesis during brain development, and that mutations to the genes resulted in abnormal brain maturation.

The researchers also did experiments in mice, and found that the more C4 activity there was, the more synapses were pruned during brain development.

Characterized by heterogeneous symptoms and a multifactorial origin, this complex condition evolves during brain development.

«These microRNAs are highly regulated during brain development and for adult brain function,» said Guven - Ozkan.

Researchers recently discovered that adult mouse neurons methylate and demethylate — startling, since experts thought methylation happened only during brain development and then became permanent, to establish cells» identities.

They also found that the disruption of the connectivity of these cells during brain development causes alterations in brain oscillatory activity and disturbs the function of place cells, a type of pyramidal neuron that becomes active when an animal is located in a particular place in its environment.

«For the first time, we have managed to show that miR - 128 is a mechanism that regulates early neuronal behaviour during brain development,» said Asst Prof Je, from the Neuroscience and Behavioural Disorders (NBD) Programme at Duke - NUS.

Increased expression of a gene linked to autism spectrum disorders (ASDs) leads to a remodeling of dendrites during brain development, according to a new study conducted in cultured neurons and an ASD mouse model published in JNeurosci.

Yi J.J., Barnes A.P., Hand R., Polleux F. and Ehlers M.D. (2010) TGFβ signaling specifies axons during brain development.

Neural circuits are remodeled during brain development and to sustain learning and memory.

A striking example is that of subjects with Agenesis of the Corpus Callosum (ACC), a congenital condition whereby the main bundle of white matter fibers connecting the two cerebral hemispheres does not form during brain development.

Yet while autism begins during brain development, and it makes sense that a developing organoid could serve as a model, looking at diseases that affect people toward the end of their lives would seem more difficult.

High throughput RNA sequencing (RNA - Seq) was performed to search for known and novel sites of adenosine to inosine (A-to-I) miRNA editing that have altered levels of editing during brain development.

The Lu lab is interested in how activity - dependent processes during brain development fine - tune the establishment of neural circuits and how neural activity affect neural circuit wiring and cognitive behaviors.

We observed in literature significant effects of HFD on rats cognition [32], and the adverse effects of methyl donor - deficient diet during brain development on memory and anxiety in adulthood in mice [33].

Most published research on sports - related concussions has been conducted in adults, and IOM says it's dangerous to assume that these findings can be mapped onto children because of the changes that occur during brain development.

The long - term scientific goal of this project is aimed at determining the role of hominoid - and human - specific gene duplications during brain development and evolution.

Animal models and clinical trials have shown that antioxidants and anti-inflammatory drugs could not only reduce symptoms associated with the disorders but also prevent the appearance of neurobiological abnormalities and transition to psychosis if given early during brain development.

Many of the eight genes are active during brain development and may play a role in neuropsychiatric disorders such as autism and schizophrenia, Sanders says.

Finally, the team identified all of the molecules that are turned on or off by GDF10 in brain cells after a stroke and compared the cells» RNA to RNA in comparable cells during brain development and normal learning, and to RNA in the brain cells of people with other diseases.

«We showed that these genes have unique expression patterns in different brain regions at varying times during brain development.