The special feature of this DNA element is its positioning in precisely those genes that play a role in the chromosome
distribution during cell division and thus influences them.
Furthermore, microtubules are the major constituents of the mitotic spindle, which mediates the orderly segregation of the replicated chromosome sets into the two daughter
cells during cell division.
«We succeeded in describing in detail the machinery required for mitochondrial genome distribution
during cell division in trypanosomes,» Ochsenreiter says.
Membrane remodeling typically
occurs during cell division, during cell movement as it slithers around, and during vesicle formation, when a small piece buds off like what you might see in a lava lamp.
The scientists involved with this study were able to demonstrate that translocations can occur within hours of DNA breaks and that their formation is independent of when the breaks happen
during the cell division cycle.
Regulator is distributed
unevenly during cell division to make two functionally and structurally different cells Some species of bacteria perform an amazing reproductive feat.
But understanding the precisely orchestrated choreography that unfolds within each
egg during cell division will eventually allow us to correct the errors, to ensure the production of healthy eggs that can be fertilized.
In a paper he published last summer in the journal Cell Cycle, Duesberg theorized that carcinogens might cause chromosomes to divide
abnormally during cell division, creating extra copies of thousands of genes and disrupting the cellular machinery — an idea with parallels to a theory floated by Julian Huxley in 1956.
Telomeres cap the ends of chromosomes and act as protection against the loss of protein - coding
DNA during cell division.
For proteins in the cytosol, the liquid inside the cell, these random molecular processes include differences in the break - down of proteins, or random partitioning into the two cells that
form during cell division.
«Ladies, this is why fertility declines with age: Age - related female infertility explained by a defect in the choreography of chromosome
sharing during cell division in eggs before they are fertilized.»
This new insight into how chromosomes are disassembled and
reassembled during cell division will allow researchers to begin answering basic questions about epigenetic inheritance, as well as human disease such as chromosome disorders and cancer.
When enzymes copy DNA
strands during cell division, they invariably make mistakes — occasionally inserting an A when they should have inserted a T, for example.
Gabriela Cabral, a PhD student in the lab of Alex Dammermann at the Center for Molecular Biology of the University of Vienna, explains: «Many people thought that centrioles are held together by the same glue as chromosomes, a substance called cohesin, which is
destroyed during cell division.
«While these macromolecules are important for the parent cell, they pose
hindrances during cell division to segregating the copied chromosomes to daughter cells properly,» said Dr. Norihiko Nakazawa, of OIST's G0 Cell Unit, the paper's first author.
Where the second type of condensin, which is present in humans and other multicellular organisms,
binds during cell division is another future line of inquiry.
The approach developed by the MGH team focuses on small areas of the human genome — so - called polyguanine (poly - G) repeats that are particularly susceptible to mutation, with genetic «mistakes» occurring
frequently during cell division.
«Telomeres function a bit like the plastic caps at the ends of shoelaces and protect the coding DNA from
loss during cell division.
The three characteristics scientists use to identify a chromosome are readily visible in an ideogram: length; the banding pattern of the dye, which reflects the type of nucleotides concentrated in the chromosome; and the location of the centromere, a waistlike constriction required for proper
movement during cell division.
While the role of chTOG in microtubule
assembly during cell division has been widely studied, not much is known regarding TACC3 and its contribution to the process.
The protein — which is not known to exist in other rod - shaped bacteria or other organisms — seems to allow for asymmetrical growth in new mycobacterial cells
made during cell division.
In an article published in Science this Thursday, a team of Portuguese researchers led by Helder Maiato identifies a» Highway Code» within cells, a finding that changes the way we perceive how chromosomes
move during cell division.
«Our hypothesis is that maybe this sort of intrinsic mechanical property — the friction these proteins experience — helps them to get where they need to be, as well as maintain the spindle's organization and mechanical
integrity during cell division,» Forth says.
The complexity of the 3 - D multicellular environment can be overwhelming, Betzig says, but the clarity of his team's imaging permits them to computationally «explode» apart the individual cells in tissue to focus on the dynamics within any particular one, such as the remodeling of internal
organelles during cell division.
The plants survived the ordeal by upping the frequency of homologous recombination (genetic swapping)
during cell division as expected.
By controlling the transport of histones to our DNA, TLK and Asf1 ensure that the chromatin architecture and its information are copied
correctly during cell division, so that cell identity is maintained,» explains Ilnaz Klimovskaia.
Researchers led by Prof. Torsten Ochsenreiter of the Institute of Cell Biology at the University of Bern have studied the mitochondria, the «power plants» of single - cell trypanosomes, and have now discovered that these behave differently from cell power plants in
humans during cell division.
However, using these cell lines it should be possible to determine in detail how the defects arise (which is difficult in patients), and perhaps how to alter the segregation of mutant versus normal
mtDNA during cell division to eventually lessen the burden of abnormal mitochondria function.
In their Nature paper, Singh's team also showed for the first time that this transcriptional repression was dependent on breakdown and reformation of the nuclear
membrane during cell division.