Sentences with phrase «during cellular senescence»
Passos JF, Saretzki G, von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
http://www.sens.org/
It is also noted that p63 isoform expression is altered during cellular senescence and that the transcription of ΔNp63 is repressed by p53 [41].
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When researchers suppressed the ARF gene in mole - rat cells during the reprogramming process to iPSCs, the cells stopped proliferation with sign of cellular senescence, while the opposite happens with mouse cells.
The biological process of cellular senescence represents an ideal paradigm to examine the role of the DNA damage response, epigenetically determined chromatin structure, and metabolic reprogramming during tissue aging and cancer development.
For example, cellular senescence is tumor suppressive and overcoming the senescence - associated cell growth arrest is a necessary step during cell transformation.
We have shown that the human condensin complex functions in global 3D genome reorganization during the important process of cellular senescence (Yokoyama et al..