Sentences with phrase «during differentiation»

The new technique could also be useful in understanding how stem cells change oxidation properties during differentiation into other cell types.

In the present study, clones of complementary DNA from genes whose expression is increased during the differentiation of adipocytes were used to study the molecular basis of cachectin's actions.

These made it possible to map the three - dimensional genome organization as well as epigenetic mechanisms during the differentiation of cardiomyocytes across the entire genome.

«We also think this method could be applied towards the development of culture conditions during differentiation of human stem cells.

«This led to the hypothesis that these tissues are «marked» for cancer predisposition during differentiation.

It's at the histone level that we saw the really profound changes during differentiation.»

In order to learn more about this process, Alexander Skupin and his team treated blood stem cells from mice with growth hormones and then watched closely how these progenitor cells behaved during their differentiation into white or red blood cells.

The team identified 29,857 regions on the genome that respond to regulatory proteins and then tracked levels of activity at six instances during the differentiation.

Ammonia, accreted either as organic matter or as ice, may have reacted with phyllosilicates on Ceres during differentiation.

Expression of MyoD, a skeletal muscle - specific transcriptional regulator, activated the expression of the Cdk inhibitor p21 during differentiation of murine myocytes and in nonmyogenic cells.

Interestingly, studies have indicated that a short G1 phase is a hallmark of pluripotent stem cells (PSCs)[2, 3], only lengthening during differentiation [4].

Recent studies have started to map the gene - wide chromatin interactions in the interphase nucleus, revealing some principles of chromosome organization into territories, and dramatic changes of chromatin organization and interactions during differentiation and lineage specification.

Mechanistically, we observed that Wnt / ß - catenin signaling orchestrates the cytoplasmic relocalization of the histone 3 lysine 9 methyltransferase Setdb1 during differentiation.

I investigated the requirement of the histone lysine demethylase KDM5A for coordination of mitochondrial metabolism during differentiation.

For example, the expression of BMP - Smad signaling pathway components is low during differentiation of mDA neurons from their VM neural precursors in vivo (E10 — E12), yet after this period, these subsequently increase in expression and play a functional role in mDA neuronal outgrowth (E1 — E18)[37].

This short review, part of the Thematic Series on Raman Spectroscopies, describes the application of Raman micro-spectroscopy to measure the molecular properties of stem cells during differentiation in - vitro.

We also tested the expression of the Venus allele during differentiation of the HV cells towards ES cell derived ADE that normally expresses high levels of Hex.

The «Cell Cycle» animated pathway shows that genes encoding regulators of DNA replication are expressed at high levels in pluripotent, self - renewing ES cells and are progressively down regulated during differentiation.

To better visualize changes in gene expression programs during differentiation, we performed k - means clustering analysis, followed by hierarchical clustering, to group genes by their timing of induction or suppression during the normal ES cell differentiation process.

267/4: 30 Extremely high resolution 3D maps of human and mouse genomes across lineages and during differentiation reveal principles of chromatin looping.

«Matt and his team performed metabolomics analysis to find out how the key metabolites within a stem cell are used up during the differentiation process.»

During differentiation of pluripotent stem cells to cardiomyocytes, the three - dimensional folding of the DNA reorganizes itself.

It has been particularly difficult to measure changes in electrical functions of cells grown within Organ Chips that are normally electrically active, such as neuronal cells in the brain or beating heart cells, both during their differentiation and in response to drugs.

Using ES cells developed at Kyoto University's Institute for Frontier Medical Sciences, the research group collected RNA and histones of each cell immediately after VEGF stimulation (0 h), before differentiation (6 h), during differentiation (12 — 24 h), and after differentiation (48 h).