Sentences with phrase «during disease development»
«Our findings will promote more investigations into how the body and mind are connected during disease development, and will facilitate better cancer treatments.»
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Therefore, manipulation of the intestinal microbiota during infancy may provide a method of disrupting allergic disease development.
Better understanding of the association between genes, lung function and lung diseases The identified genes open up new molecular biological approaches for a better understanding of lung development and of the repair and remodelling processes during disease pathogenesis.
The team says it is not clear whether the unwanted connections are indispensable stepping stones or routine «overshoots» but the discovery may throw new light on diseases thought to result from misconnections during brain development, such as autism.
«Policy makers need to heed data such as those presented by Morales et al as limiting exposure to traffic - related pollution during fetal development and early postnatal life is one way that the burden of respiratory disease can be decreased.»
EPIGENOME DEBUT Chemical modifications to DNA and histones can influence how genes are turned on and off during development and in health and disease.
In the future, our technique could help people understand the details of a disease by providing snapshots of proteins synthesized in specific cells at different times during development and allowing comparisons of healthy and diseased cells.
McCain would ban scientists from using donor eggs to create disease - specific stem cell lines or chimeric animals to see how human stem cells behave during development.
Thus, in utero nutritional exposures during critical windows of germ cell development can impact the male germline methylome, associated with metabolic disease in offspring.
Thus, as estrogen levels fall during menopause, the risks of increased blood pressure and development of cardiovascular disease increases.
In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome — DNA, epigenetic markers and RNA — during the development, maturation and disease of human cardiac muscle cells.
This is important, he added, because this technique is increasingly used for classifying diseases and their subtypes, understanding gene expression changes during development and tracking the progression of cancer.
As the messenger of genetic information, RNA plays an important regulatory role in cell and tissue development as well as during disease progression.
The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.
As such, it can help researchers observe changes in synapses during brain development and disease.
Dr Kollmannsberger said: «The quantification we developed could be useful in assessing bone quality during physiological development or pathological conditions of age, disease and pharmaceutical intervention, complementary to existing measures such as bone mineral density.
The study is the first to link asthma to hexachlorobenzene exposure during fetal development, and builds on two earlier studies that linked the respiratory disease to polychlorinated biphenyls.
Preclinical studies suggest that Cdk5 is a gene that is important for the normal wiring of the brain during early development and may be involved in some neurodegenerative disorders, including ALS, Parkinson's and Alzheimer's disease.
During pregnancy, women have decreased incidence of rheumatoid arthritis, yet they have an increased incidence of disease development and flare during the post-partum pDuring pregnancy, women have decreased incidence of rheumatoid arthritis, yet they have an increased incidence of disease development and flare during the post-partum pduring the post-partum period.
While this process is essential during development, it appears to be hijacked in diseased or traumatic conditions to reactivate and accelerate neuron degeneration.
He explained that it's likely that these genes do not function properly during development in patients suffering from schizophrenia, epilepsy, or other diseases.
Exposing infants and children to higher amounts of sugar during growth and development can produce problems with cognitive development and learning as well as create lifelong risk for obesity, diabetes, fatty liver disease and heart disease, said Goran, founding director of the Childhood Obesity Research Center at the Keck School of Medicine.
Further insight into the mechanisms by which bladder bacteria and antimicrobial peptides communicate during normal and disease states will facilitate the development of better prevention and / or treatment strategies for UTI - susceptible populations.
Molofsky is a psychiatrist who studies how astrocytes organize nerve circuits, and how disruptions of these nerve circuits during development or disease may involve abnormal astrocyte function.
Professor Sinclair said: «It is well established that prior to conception and in the early stages of pregnancy during natural or assisted reproduction subtle chemical changes can affect the human genome leading to development and late - onset chronic diseases.
Newbold said because decades can pass between exposure during fetal development or early childhood and the manifestation of the disease in adult life, it can be difficult to nail down a link.
«Gynecological problems during the reproductive years may be a predictor of diseases, such as cancer, later in life,» said Barbara Cohn, a reproductive health scientist and director of Child Health and Development Studies at the Public Health Institute in Berkeley, Calif..
Scientists at the Montreal Neurological Institute and Hospital - The Neuro, McGill University, have made important discoveries about a cellular process that occurs during normal brain development and may play an important role in neurodegenerative diseases.
In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome - DNA, epigenetic markers and RNA - during the development, maturation and disease of human cardiac muscle cells.
Neurology Central, an online publication based in the United Kingdom, will sponsor a live webinar with MDI Biological Laboratory scientist James A. Coffman, Ph.D., on the subject of how chronic stress experienced during early development epigenetically programs adult disease risk.
With our unique robotic microscope technology, can we identify the major determinants of cell fate during normal development of stem cells and in neurodegenerative disease?
We aim to comprehensively annotate functional elements, decipher genomic codes of transcription, as well as coding and non-coding gene function during development and enhance zebrafish as an attractive developmental, comparative and disease model.
«Identifying druggable targets that participate during the pre-symptomatic stage of the disease is particularly important,» Nishina says, «to enable development of therapies that can prevent, delay onset or decrease the severity of RPE - associated diseases irrespective of the initial cause of the disease.»
Although the original impetus of the work was to study human brain disease and development, says Howard Hughes Medical Institute (HHMI) Investigator Christopher Walsh, the results also shed light on how the human brain expanded during the course of evolution.
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Together, our results suggest a comprehensive model of chromatin dynamics during development and set the foundation for similar work on human blood formation and disease.
This is important because we know that the procedure is not perfect, generally transmitting disease mtDNA at low levels as is the case here, and we now know that tissue - specific expansion of mutated mtDNA during development can occur (Naue, 2015) and so could cause disease if levels are high enough.
«The results suggest that such «master» regulatory factors could activate regions of the genome that are normally inactive, leading to the formation of organs during development, or the initiation of pathological changes in cells that lead to diseases such as cancer,» Taipale said.
Although genetics plays a large role in the development of congenital heart disease, the leading non-genetic risk factor for the disease is a mother having diabetes during pregnancy.
Determination of transporter distributions and densities around select synapses in normal adult brains and how these parameters change during development, ageing, drug use and disease
By understanding how the transcription factors work together during heart development, researchers may discover new ways to treat heart disease.
This work defines a new synapse disease occurring during development, in technical terms a neuro - developmental synaptopathy, caused by the deficiency of the PTCHD1 gene associated with ID and autism.
Immune - based strategies to treat pancreatic cancer during the early stages of development, as well as new immunological approaches to treat advanced disease, are showing significant promise where other approaches have failed.
Yet while autism begins during brain development, and it makes sense that a developing organoid could serve as a model, looking at diseases that affect people toward the end of their lives would seem more difficult.
«We are particularly proud of our colleague Dr. Campbell whose innovation, passion and dedication to fighting diseases during his 30 - year career at Merck enabled the development of Mectizan,» said Kenneth C. Frazier, chairman and chief executive officer, Merck.
Her scientific expertise lies in understanding the epigenetic basis of gene regulation during embryonic development and disease ontology.
In a search for ways to inhibit pathologic production or activities of VEGF without affecting its normal production or functions, we investigated the post-transcriptional regulation of VEGF by the cytoplasmic polyadenylation element - binding proteins CPEB1 and CPEB4 during development of portal hypertension and liver disease.
Since the signalling mechanisms affected in these diseases are the same mechanisms that occur during embryonic heart development, their study is a subject of great interest and relevance.
Our lab uses both cardiomyoctes derived from human stem cells (iPS cell - derived cardiomyocytes) and mouse models harboring the human mutation to study which exact changes occur during the onset and development of the disease.
The research lines of the Bakkers group include unraveling the genetics of normal cardiac development and body axis formation during development, investigating the molecular mechanisms of heart regeneration in the zebrafish and how this can be compared to heart injury in the mammals, and modeling of human (cardiac) disease in the zebrafish to unravel biological mechanisms behind the disease and to identify new drug targets.