Sentences with phrase «during drug design»

Not exact matches

In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth of Otezla sales had dramatically slowed during Celgene's third fiscal quarter of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDA.

Instead of delivering the drug continuously at a steady rate, the hydrogel is designed to respond to increased disease activity during flares, releasing the drug when symptoms worsen.

«The hydrogel is designed so that drug release is triggered by the activity of specific, arthritis - related enzymes that are increased during flares.

During the past year the team was awarded an National Science Foundation and two NIH grants to design nanocarriers for targeted drug delivery through a combination of computer modeling and laboratory experiments.

By understanding how neuregulin 3 acts in the brain, researchers could conceivably design drugs to restore its function during schizophrenia.

Vaquer designed experiments to test the behavior of drugs in microgravity during his spare time, while he was working in the lab of pharmacologist Rafael de la Torre at IMIM, focusing on a family of membrane proteins called ABC transporters.

«We think that understanding the role of isoprenoids during gametocytogenesis and identifying metabolic steps absent or sufficiently different from its human host will allow us to design more efficient drugs to block malaria transmission, which is one of the key components for malaria elimination and eradication,» Cassera said.