Sentences with phrase «during embryonic»

These observations show that trace - element depletion can occur during embryonic development and the postnatal period.

A cleft palate is an abnormal opening in the roof of the mouth and it occurs because the two sides of the roof of the mouth (the palate) did not come together and fuse during the embryonic development while your cat was in utero.

While The American Journal of Clinical Nutrition reports «craniofacial... malformations» (those affecting the head and face) occurring in animals exposed to high Vitamin A intake during embryonic development

On rare occasions ectopic thyroid tissue (abnormal migration of thyroid tissue during embryonic development) can give rise to lesions in the tongue, ventral neck, cranial mediastinum and heart base.

While research is limited, scientists do know that the endocannabinoid system is present even during the embryonic stage.

«Importantly, we have achieved our insights by mimicking molecular processes occurring during embryonic cartilage formation,» says Ivan Martin.

Prof. Dr. Ivan Martin's research group at the Department of Biomedicine has now been able to demonstrate that by forcing certain molecular events occurring during the embryonic development of articular cartilage it is possible to generate stable cartilage tissue from adult human mesenchymal stem cells.

In a similar manner, the induction of hematopoietic (cluster 20, day 3.5 +4 = E7.5) and cardiovascular - specific (cluster 12, 3.5 +5 = E8.5) genes follows the chronological order of the appearance of blood islands and the formation of the heart tube during embryonic development [50], [51].

Since the signalling mechanisms affected in these diseases are the same mechanisms that occur during embryonic heart development, their study is a subject of great interest and relevance.

Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic development.

The sequential appearance of genes specific to early developmental stages matches the timing of their induction during embryonic development.

CAMBRIDGE, Mass. — Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during embryonic brain development in zebrafish.

To confirm that the expression of the Venus allele reflects endogenous Hex expression [28], [33], [34], we used two HV clones to generate chimeras and examined the sites of high - level Venus expression during embryonic development.

Her scientific expertise lies in understanding the epigenetic basis of gene regulation during embryonic development and disease ontology.

La Jolla, CA — Scientists at the Salk Institute have discovered a novel genetic pathway that ensures body organs develop correctly and in the right position during embryonic development.

Eight HARs showed differences in their enhancer activity when the human mutations were present.4 These differences modify how genes were expressed in the developing limb (HAR2, 2xHAR114), eye (HAR25), and central nervous system (2xHAR142, 2xHAR238, 2xHAR164, 2xHAR170, ANC516 / HARE5).4, 10 Because relatively few time points have been examined, it is likely that an even higher percentage of the tested HARs are active enhancers at some point during embryonic development or in adult tissues, possibly with human - chimp differences.

Dr. Péault is internationally recognized principally for his work on the prospective identification and characterization of human hematopoietic (blood) stem cells, of which his laboratory has also deciphered the ultimate origin during embryonic life.

During embryonic development, cells use the information contained in their genome to build the organism.

Integrating this new information into computational models, my colleagues and I predicted that about 5 percent of HARs function as noncoding RNAs, while most are enhancers that control gene expression during embryonic development.9

The research team hypothesized that HARs instead acted as «enhancers,» controlling when and for how long certain genes were switched on during embryonic development.

Several of our research projects are designed to advance understanding of the genetic mechanisms whereby specific cell types fulfill the unique functions of building our skeleton during embryonic and postnatal development and maintaining it through adulthood.

Most Alkbh1 deficient mice die during embryonic development, and survivors are characterized by defects in tissues originating from the ectodermal lineage.

Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, came a step closer to understanding how cells close gaps not only during embryonic development but also during wound healing.

Mary Halloran, professor of zoology, works to understand how neural circuits form during embryonic development.

They found that groups of genes appear to work together in heart cells in a coordinated fashion — switching on and off as a group at designated times during embryonic development.

The researchers also identified new links between aggressive meningioma proliferation and activation of an intercellular signaling pathway called Wnt — which typically plays a role during embryonic development and tissue formation.

A switch has been discovered that instructs blood vessel cells to become blood stem cells during embryonic development in mice.

Title: A genome - wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation (IN PRESS, Oct 2012) Authors: Sharrocks A, Yang S - H, Kalkan T, Haslam C, Smith A Date: IN PRESS, Oct 2012 Publication Details: PLoS Genetics

The telomeres are produced during embryonic development but start to crumble away as cells mature and divide.

In his postdoctoral training at Metrohealth Medical Center, Duke University Medical Center, and Mt. Sinai Medical Center, he has been interested in the maintenance of electrical function in the heart during embryonic development and in heart failure models.

seek to identify the mutational processes underlying mutational signatures found in cancers, characterise the mutational processes operating in normal cells, use phylogenetic analyses of somatic mutations in humans to explore cellular lineages during embryonic development

Correspondingly, endothelial - specific deletion of Tie2 using Ve - cad - Cre driver mice, pursued in validating the Tie2fl / fl mice used in this study, essentially phenocopied the global Tie2 KO phenotype with embryonic lethality around E10.5 (Supplementary Fig. 13), confirming the key role of endothelial Tie2 during embryonic development.

The process of neuronal specification is the acquisition of definitive phenotypic characteristics for a given subclass of neurons during embryonic development.

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during embryonic development Stefan Schulte - Merker, Westfälische Wilhelms - Universität Münster

During embryonic development, neurogenesis proceeds maintaining a fine balance between mechanisms that support self renewal of undifferentiated radial progenitors and others that instruct precursors to commit to specific fates and achieve terminal differentiation.

Identification and Expression Analysis of Zebrafish Glypicans during Embryonic Development.

Karolina Jastrezbowska (Tomancak, MPG)-- «Evolution of gene expression regulation during embryonic development of Drosophila species» (2010)

In the new research, Pollen and co-first author Tomasz Nowakowski, PhD, also a postdoctoral researcher in the Kriegstein lab, partnered with Fluidigm Corp. to develop a microfluidic approach to map out the transcriptional profile — the set of genes that are actively producing RNA — of cells collected from the VZ and SVZ during embryonic development.

In parallel, the roles of symmetric and asymmetric cell divisions are investigated as a mechanism for governing stem cell self - renewal and differentiation during embryonic development and in the adult.

During embryonic development, mesenchyme (embryonic stroma) is critical for pancreatic development even though only the epithelium gives rise to the pancreas.

The researchers suggest that since the adult muscle stem cells are only activated when injury occurs (by trauma or exercise), they use a new set of genes from those used during embryonic development, which proceeds without injury.

We have found that epithelium and mesenchyme / stroma are also coordinately regulated during embryonic development.

Researchers have identified genes that play a role in the condition, some of which are essential for cerebral cortex growth during embryonic development.

This is made possible by inducing specific molecular processes occurring during embryonic...

«We found that IL - 34 is an essential growth factor for the differentiation of Langerhans cells and microglia during embryonic development,» says senior author Marco Colonna, MD, professor of medicine and of pathology and immunology.

This migration may happen because the repair pathways initiated by the damaged cells are similar to pathways triggered during embryonic development, where stem cells are key, explains ReNeuron co-founder and chief scientific officer John Sinden.

However, malformation of skeletal bones during embryogenesis also occurs in FOP patients and illustrates that the underlying genetic mutation occurs in a gene with functional importance in regulating chondro - osseous differentiation during embryonic skeletal development as well as in adult musculoskeletal tissues.

It increases the likelihood that the urinary tract will not form properly during embryonic development.

Matthew Kelley, a developmental neuroscientist at the National Institute on Deafness and Other Communication Disorders in Bethesda, Maryland, applauds the method of introducing the Atoh1 during the embryonic stage.

Mutations in these animals began to amass during embryonic development, while normal animals don't begin to accumulate mutations until after birth.