They found that groups of genes appear to work together in heart cells in a coordinated fashion — switching on and off as a group at designated
times during embryonic development.
«Observing the changes in the architecture of islets
during embryonic development in mice and in pseudoislets — a model we generated in our lab — was also very interesting.
Among other things, the gene is involved in the migration of nerve cells to the
brain during embryonic development, and it also regulates the cytoskeleton and molecular motors in the cell.
As specialized cells are
generated during embryonic development, they are programmed to use only a limited amount of the total genetic information present in the nucleus to produce the proteins required for their particular function.
The two types of blood vessels, arteries and veins, are formed from the same precursor cell type — endothelial cells — that become committed to an arterial or venous cell
fate during embryonic development.
On rare occasions ectopic thyroid tissue (abnormal migration of thyroid
tissue during embryonic development) can give rise to lesions in the tongue, ventral neck, cranial mediastinum and heart base.
Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are
produced during embryonic development, also helps maintain FSCs throughout the life of the animal.
Seeking fresh sources, they looked for cells that express the gene neurogenin 3, a potential sign of cell differentiation because it is the first gene to only switch on in pancreatic
islets during embryonic development.
Previous studies by Prins and colleagues using rats showed that exposure to elevated estrogen or
BPA during embryonic development increased the rate of prostate cancer later in life.
Instead of mimicking the complex 3D organization of the developing pituitary gland, this approach relies on the precisely timed exposure of human pluripotent stem cells to a few specific cellular signals that are known to play an important
role during embryonic development.
In experiments on zebrafish, Freiburg researchers have demonstrated that the same proteins that lead to the formation of metastases in humans also cause the cells to
migrate during embryonic development.
The University of California, San Diego, team that conducted the research focused on so - called Hox genes, master switches that turn other genes on and
off during the embryonic development of all animals, including humans.
If these mutations
happen during embryonic development, there could be several neurological problems: the child could become autistic, kids could be born with seizure disorder, or the developing neurons might not migrate to their proper site in the brain.
Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous
system during embryonic development in mice.
In their study, the Heidelberg researchers discovered that accurate vascularisation of the spinal
cord during embryonic development is a highly precise mechanism, which requires a complexly regulated balance between growth - stimulating and growth - inhibiting factors.
«Our findings lend new weight to the hypothesis that there are specific functional categories of genes — likely conserved by evolution in development of the human neurological system and brain — that strongly contribute to autism's causation, such as genes
expressed during embryonic development and genes that encode proteins that remodel chromatin, the bundles in which our DNA is stored,» says Research Assistant Professor Michael Ronemus, a member of the CSHL team.
During embryonic development individual cells and cell clusters can move over relatively long distances, and cell migration is also essential for wound healing and many immunological processes in adult animals.
Turtles are the only beasts in the animal kingdom that don hard outer shells formed from
bone during embryonic development, and a scarcity of ancient turtle fossils has made it difficult to track the evolution of this unique trait.
This migration may happen because the repair pathways initiated by the damaged cells are similar to pathways
triggered during embryonic development, where stem cells are key, explains ReNeuron co-founder and chief scientific officer John Sinden.