Using Plk4 overexpression (PLK4OE)
during epidermal development, we assess the impact of centrosome amplification and aneuploidy on skin development and tumorigenesis.
Not exact matches
Interestingly, they found that stem cells coming from different
epidermal compartments present very similar response
during wound repair, despite the fact that they are recruited from different regions of the epidermis.
One of the key metabolic alterations that takes place
during EMT is that of the
epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.
«We have already observed that gene egr - 4 is regulated by the
epidermal growth factor receptor (EGFR) signaling pathway, so it will enable to identify also the factors that activate this pathway
during anterior regeneration.
During wound healing differentiated Gata6 (+) cells migrate from the SD into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long - term self - renewal and differentiate into a much wider range of
epidermal lineages than in undamaged tissue.