Sentences with phrase «during human and mouse»

The RNAs of enhancers are expressed before the genes they regulate during human and mouse cell differentiation.

Not exact matches

Infant calming responses during maternal carrying in humans and mice.

Infant Calming Responses during Maternal Carrying in Humans and Mice.

A study by researchers at the University of Chicago Medicine shows that when mice that are genetically susceptible to developing inflammatory bowel disease (IBD) were given antibiotics during late pregnancy and the early nursing period, their offspring were more likely to develop an inflammatory condition of the colon that resembles human IBD.

The study examined specific immune pathways known to be activated during flu infections in both humans and mice, which makes the findings relevant to children.

The researchers, reporting online March 5 in the American Journal of Reproductive Immunology, also say they found that an anti-inflammatory drug that is FDA - approved for rheumatoid arthritis and is believed to be safe for humans to take during pregnancy halted the brain injury in mouse offspring.

«Even the timing of the emergence of symptoms in the mice — during young adulthood — parallels the onset of schizophrenia in humans,» said Joseph Gogos, PhD, a professor of physiology and neuroscience at CUMC, a principal investigator at the Zuckerman Institute and a lead author of the paper.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

Before birth, mouse and human ovaries contain an abundant supply of germ cells, some of which will develop into the eggs that will ultimately be released from follicles during ovulation.

Fittingly, most of these genes reside in ampliconic regions of the X and appear to have been acquired independently during the 80 million years since mouse and human diverged from a common ancestor.

This factor is the first lung molecular marker during mouse and human development and is essential for lungs to mature properly in an embryo.

Walford's new research is based on the fact that in mice and humans, the immune system malfunctions during aging, losing the ability to distinguish between healthy cells and invasive pathogens such as bacteria and viruses.

To find out why, they examined genes in both mice and humans that turned on during peak brain development and spotted a DNA snippet, ARHGAP11B, that was active only in humans.

Galatzer - Levy analyzed data from large studies in humans and mice that involved «fear conditioning» and «fear extinction,» during which subjects receive a mild aversive stimulus when exposed to a sound or light, and «fear extinction learning,» during which conditioning is reversed by applying sound or light without the stimulus.

What we do know is that in mice (and so, presumably, in humans) FOXP2 is active in the brain during embryonic development.

She looked after her children during the first year and took a postdoc on mouse models of human fertility in a genetics group at the Stanford School of Medicine in their second year in California.

Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T cells and monitor in a dish both how those cells now fight the tumor and react to healthy human tissue.

During this BSA Lecture, Kevin Esvelt of Massachusetts Institute of Technology discusses his lab's work with communities on Nantucket and Martha's Vineyard to prevent tick - borne human illness by developing hereditary traits in mice that could immunize them, removing a vital link in the spread of Lyme disease.

In fact, though many human and mouse genes appear to be similar, they may have taken on slightly different roles, or be active at different times during the life of a person or a mouse.

During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution of mouse models of human diseases:

Appearance of an oocyte activation - related substance during spermatogenesis in mice and humans.

«Over the past ten years, several research groups, including our own, have shown the importance of certain immune cell subsets in preventing or exacerbating heart disease in mice, but we are just beginning to understand how the metabolism and function of these immune cells change during cardiovascular disease progression in humans,» says Hedrick.

During his work, Clarence also carried out investigations into cancer and observed that many mouse tumours acted in the same way as human ones.

They went on to show that Sox10, a factor needed for the formation of skin pigment cells from neural crest stem cells during development, was present at high levels in naevi and melanoma samples obtained from both the mouse model and human patients.

On the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude mice.

267/4: 30 Extremely high resolution 3D maps of human and mouse genomes across lineages and during differentiation reveal principles of chromatin looping.

Our lab uses both cardiomyoctes derived from human stem cells (iPS cell - derived cardiomyocytes) and mouse models harboring the human mutation to study which exact changes occur during the onset and development of the disease.

CAST / EiJ mTR — / — mice exhibit significant deficits in tissue renewal during adulthood, even in the first generation, and progressive worsening of the phenotype with successive generations, similar to what is seen in other background strains with these mutations and in the genetic anticipation observed in successive generations of families with autosomal dominant forms of the human genetic disorder of telomerase components, dyskeratosis congenita.

Intrigued by recent findings that neuron firing rates in the regions of mouse and fly brains associated with visual processing increase during physical activity, UC Santa Barbara psychologists Barry Giesbrecht and Tom Bullock wanted to know if the same might be true for the human brain.

Different mutations in HSF4 have been reported to cause both human autosomal dominant and recessive cataracts [97 — 99] and studies in mice have shown HSF4 is required for normal fibre cell differentiation during lens development [100, 101].