«What we show is that the Zika virus infects neuronal cells in dish that are counterparts to those that form the cortex
during human brain development.»
The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression
during human brain development.
Not exact matches
«Stimulating your child's
brain during this time and providing situations where they can explore helps them to learn things that get them in touch with their environment,» says child and adolescent psychologist Robert Myers, Ph.D., founder of the Child
Development Institute and assistant clinical professor of Psychiatry and
Human Behavior at the University of California, Irvine School of Medicine.
The growth of head circumference, an indicator of
brain development, is not lower
during premature hospitalization in infants fed
human milk, even when the breastfed infant weighs less.
There are unique considerations regarding the needs of infants
during the first three years of life which are highlighted by contemporary knowledge, underscoring the impact of early experience on the
development of
human infant
brain and mind»
Tests were conducted in Sweden by scientists, curious as to the affects ultrasounds may have on the
human brain during development.
The LPS was given at a time point that approximates the stage of
brain development in
humans right at the time of birth, thus mimicking the
development of a bacterial infection
during delivery.
Finally, says Evrony, the findings provide a proof - of - principle for a systematic way of studying how
brain cells disperse and migrate
during development, «something that has not been possible to do before in
humans,» he says.
During development, subplate neurons are among the first neurons to form in the cerebral cortex — the outer part of the mammalian
brain that controls perception, memory and, in
humans, higher functions such as language and abstract reasoning.
Most
human brain development happens in the womb and
during suckling.
One possibility is that it's just random events
during development, that as a few neural stem cells in a fetus give rise to a hundred billion nerve cells in an adult
human brain, a lot of stuff happens.
Finally, Niels Rattenborg from the Max Planck Institute for Ornithology in Seewiesen hopes that «this naturally occurring variation in REM sleep
during a period of
brain development can be used to reveal exactly what REM sleep does for the developing
brain in baby owls, as well as
humans.»
The method could also help biologists understand how tissues change subtly
during embryonic
development — and even help map the maze of neurons that wire the
human brain.
Instead, it makes an RNA molecule that is present
during early in utero
brain development and may orchestrate the migration of cells that build the
human brain.
Currently, the organoids are roughly equivalent in size to a
human brain during early fetal
development.
In the new study, the researchers discovered that
during the second trimester of
human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.
To find out why, they examined genes in both mice and
humans that turned on
during peak
brain development and spotted a DNA snippet, ARHGAP11B, that was active only in
humans.
What we do know is that in mice (and so, presumably, in
humans) FOXP2 is active in the
brain during embryonic
development.
The group investigated the ability of
human neural cells to aid the formation of blood vessels
during brain development.
Although the original impetus of the work was to study
human brain disease and
development, says Howard Hughes Medical Institute (HHMI) Investigator Christopher Walsh, the results also shed light on how the
human brain expanded
during the course of evolution.
In contrast to mouse vRGs, which produce 10 to 100 daughter cells
during brain development, a single
human oRG can produce thousands of daughter neurons, as well as glial cells — non-neuronal
brain cells increasingly recognized as being responsible for a broad array of maintenance functions in the
brain.
The identification of the genetic mechanisms underlying
human - specific
brain development during evolution will transform our ability to decipher the pathophysiological mechanisms underlying neurodevelopmental disorders affecting
humans such as autism or schizophrenia.
We are currently using this new paradigm to define the expression and function of other hominoid - and
human - specific gene duplications
during brain development and evolution.
This is a unique scientific paradigm: the first publication determining the role of
human - specific gene duplications
during brain development came out of our laboratory recently (Charrier et al., 2012) and represents a milestone in our understanding of the genetic and neurobiological mechanisms underlying the emergence of
human - specific traits of
brain development, for example neoteny
during synaptic maturation (Benavides - Piccione et al., 2002; Petanjek et al., 2011).
The Swedish part of the effort, called the
Human Developmental Cell Atlas (HDCA) program, includes researchers from Karolinska Institutet, Stockholm University and KTH, focusing on
brain, lung, heart and fetal
development during the first 12 -LSB-...]
During the next two to three months, the cells began to organize themselves into layers and clusters of different cell types, paralleling what happens during the first eight to 10 weeks of human fetal brain develo
During the next two to three months, the cells began to organize themselves into layers and clusters of different cell types, paralleling what happens
during the first eight to 10 weeks of human fetal brain develo
during the first eight to 10 weeks of
human fetal
brain development.
Changes in lipidome composition
during brain development in
humans, chimpanzees, and macaque monkeys.
While researchers have been able to study how DISC1 mutations alter the
brain during development in animal models, it has been difficult to find the right tools to study changes in
humans.
During development, the healthy
human brain constructs a host of large - scale, distributed, function - critical neural networks.
Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles
during brain development in zebrafish, and went on to show that the
human versions of these RNAs can substitute for the zebrafish lincRNAs.
Models of
human brain development have long posited that functional areas become increasing segregated
during the first two decades of life.
Inappropriate hormone levels can have a devastating effect on the developing
human brain, especially
during the first 12 weeks of pregnancy when the fetus depends on the mother's thyroid hormones for
brain development.
Here we demonstrate that bisphenol A exposure
during a time point analogous to the second trimester in
humans has real and measurable effects on
brain development and behavior.
Research shows that the first five years are the most crucial for a child's long - term prospects: 90 percent of
human brain development occurs
during that period.
Scientific research in the past 30 years regarding the neuro -
development of the
human brain during childhood directly challenges the basic premises of the behaviorist approach to treating children, and the scientific evidence on neuro -
development during childhood offers more effective treatment alternatives beyond merely rewarding «good behavior» and punishing «bad behavior.»
There are unique considerations regarding the needs of infants
during the first three years of life which are highlighted by contemporary knowledge, underscoring the impact of early experience on the
development of
human infant
brain and mind»