Sentences with phrase «during hypoxia»

In 2007, we showed that astrocytes release adenosine to modulate glutamatergic synaptic transmission during hypoxia.

Functional imaging using in vivo confocal microscopy which allows the analysis of vaso - activity phenomena during hypoxia, of ischaemia reperfusion events, or of homing cells in pathologic processes, such as tumours or inflammatory diseases.

Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH (2012) Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells Cell Oncol (Dordr), 35 (3), 217 - 27 PubMed 22700320

Direct Transcriptional Up - regulation of Cyclooxygenase - 2 by Hypoxia - Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF - 1 Transcriptional Activity during Hypoxia

Northern blotting analyses were performed on control and 3 h hypoxic samples to confirm that mRNA levels for P0 remained unchanged during hypoxia.

Most of the genes that were upregulated during hypoxia in our study are not known to be controlled by HIF - 1.

GSEA demonstrated significant enrichment in NMDAR subunit expression both during hypoxia and following recovery.

Results: HIF - 1α protein, but not mRNA, was elevated up to 15-fold during hypoxia, beginning at 0.5 h, the shortest duration examined.

The Altieri lab showed that the protein Akt, which plays a key role in cell signaling and metabolism, accumulates in mitochondria during hypoxia.

Not exact matches

That's probably a subjective experience of hallucinations induced by hypoxia during cardiac or respiratory arrest, and no - one who has actually been brain dead has ever come back to talk about it.

The prone or side sleep position can increase the risk of rebreathing expired gases, resulting in hypercapnia and hypoxia.54, — , 57 The prone position also increases the risk of overheating by decreasing the rate of heat loss and increasing body temperature compared with infants sleeping supine.58, 59 Recent evidence suggests that prone sleeping alters the autonomic control of the infant cardiovascular system during sleep, particularly at 2 to 3 months of age, 60 and can result in decreased cerebral oxygenation.61 The prone position places infants at high risk of SIDS (odds ratio [OR]: 2.3 — 13.1).62, — , 66 However, recent studies have demonstrated that the SIDS risks associated with side and prone position are similar in magnitude (OR: 2.0 and 2.6, respectively) 63 and that the population - attributable risk reported for side sleep position is higher than that for prone position.65, 67 Furthermore, the risk of SIDS is exceptionally high for infants who are placed on their side and found on their stomach (OR: 8.7).63 The side sleep position is inherently unstable, and the probability of an infant rolling to the prone position from the side sleep position is significantly greater than rolling prone from the back.65, 68 Infants who are unaccustomed to the prone position and are placed prone for sleep are also at greater risk than those usually placed prone (adjusted OR: 8.7 — 45.4).63, 69,70 Therefore, it is critically important that every caregiver use the supine sleep position for every sleep period.

Our son Silas was born 5 weeks prematurely, and suffered grave hypoxia due to complications during the delivery.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

This suggests that the effects of hypoxia could be more significant during whole body exercise, in which the stress on the cardiovascular system is more pronounced.

They argue that fetal monitoring trials have focused on uncommon outcomes, such as cerebral palsy, which is rarely linked to hypoxia during labour, and say «we should be focusing on other forms of evidence relating to the more common outcome with serious long term implications — namely, neonatal encephalopathy.»

Electronic fetal monitoring is often used during labour to detect unborn babies at risk of brain damage (neonatal encephalopathy) from a lack of oxygen (hypoxia).

Says DePinto, «To the extent that the winter production of phytoplankton organic matter is still available for oxygen - demanding decomposition during the summer stratified period, it will contribute to Central Basin hypoxia.

In the model, the severity of hypoxia is driven by a combination of physical factors such as the thickness of the dense, bottom layer of water during stratification, the degree of wind - driven vertical mixing, and the growth of phytoplankton induced by phosphorus loading.

Hypoxia at the bottom of Lake Erie occurs during the summer as a result of biological activity in the colder bottom layer that consumes dissolved oxygen in the water.

And if the air pressure drops suddenly — as can happen during military manoeuvres — even pilots specially trained to spot hypoxia can have little time to do so before losing consciousness.

By testing the sensor on volunteers during a simulation in which oxygen levels were cut, the team was able to identify a set of VOCs signalling the onset of hypoxia.

The effects of chronic prenatal hypoxia on the fetal and adult offspring cardiovascular system are prevented by maternal treatment with vitamin C during pregnancy.

The implications of these data are that maternal treatment with antioxidants may provide possible therapy against the programming effects on vascular dysfunction in pregnancy complicated by fetal hypoxia, such as during placental insufficiency, preeclampsia, gestational diabetes or high altitude pregnancy.

Therefore, the primary novelty of the discoveries reported here is that programming by prenatal chronic hypoxia of cardiac and vascular dysfunction in adulthood follows the induction of oxidative stress in the fetal heart and vasculature, and that cardiac and endothelial dysfunction in adulthood can both be prevented by maternal treatment with antioxidants during pregnancy.

Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring.

The aims are to study the adaptive response and damage / repair mechanisms of the foetus and newborn to a poor pre - and perinatal environment as during severe preeclampsia (asphyxia, hypoxia, growth restriction), chronic intrauterine infections and perinatal insults related to hypoxia and inflammation.

Increased oxidative metabolism and myoglobin expression in zebrafish muscle during chronic hypoxia.

The data presented in this article suggests that tumor subtype needs to be taken into account during treatment design as blocking angiogenesis and therefore increasing tumor hypoxia may be beneficial in the treatment of ER - α — negative breast cancer but could have catastrophic effects on ER - α — positive breast cancer.

Perinatal hypoxia during birth was less in the women who took the magnesium supplements when pregnant.

That response was even better during certain stages of the menstrual cycle in younger female rats, suggesting female hormones play a role in the response to hypoxia during sleep.

In a study involving rats, researchers discovered that young male rats respond to normal episodes of hypoxia, or brief periods of oxygen deprivation, during sleep by increasing brain activity to take deeper and more frequent breaths.

«Hypoxia» is a condition where your body's tissues don't get enough oxygen, and while it might feel strange or stressful, limiting your breathing during a workout can strengthen your heart.

If you believe that your doctor or hospital in New Orleans made mistakes that led to hypoxia during pregnancy or delivery and Cerebral Palsy in your child, you may have grounds to pursue a medical malpractice claim that can help protect other families from a similar outcome.

When you have reason to believe that your doctor's decisions caused hypoxia to your baby during delivery in New Orleans, call us at [phone] for a free consultation with an experienced birth injury and medical malpractice attorney.

According to the plaintiff, during the latter part of the pregnancy and on the day the baby was born, the defendants failed to respond properly to obvious signs of fetal distress which caused serious hypoxia; this resulted in the infant suffering permanent brain damage.

Fetal hypoxia occurs when a a fetus is deprived of sufficient oxygen during the birthing process.

Hypoxia and hypoxic - ischemic encephalopathy often occurs during childbirth due to various reasons, but the underlying cause is often the direct result of medical malpractice or negligence by the obstetrician (OB / GYN), nurse, midwife, doctor, or other medical professional.

If your child's cerebral palsy was caused by hypoxia during delivery, that fact might be reflected in low Apgar scores (delivery room measures of respiration, color, muscle tone, reflexes and heart rate) or a blood pH that is below 7.20.