Sentences with phrase «during mitosis»

The researchers reported that TBK1 directly binds to and activates two proteins called CEP170 and NuMA that are involved in the separation of chromosomes during mitosis.

After the parental cell DNA is replicated, the duplicated DNA and cellular organelles are separated into two daughter cells during mitosis.

We are particularly interested in the processes that ensure correct chromosome segregation during mitosis.

We are using these systems to explore the mechanisms that control spindle orientation during mitosis, epithelial homeostasis, and multipotency versus unipotency in mammary stem cells.

Condensin in turn tethers these highly active genes to centromeres, such that they are protected and faithfully segregated during mitosis.

His first renderings of chromosomes separating during mitosis weren't much more sophisticated than his earlier plasticine worms.

Simple genetic mutations that take place during mitosis can also cause a discrepancy in DNA test comparisons.

Meiosis uses many of the same biochemical mechanisms employed during mitosis to accomplish the redistribution of chromosomes.

Next, they modified the repair proteins in order to impose DNA repair during mitosis, and watched what happened.

«Cells do not repair damage to DNA during mitosis because telomeres could fuse together.»

This revealed telomeres as dangerous structures during mitosis, because the cells momentarily lost the ability to distinguish between damaged DNA strands and normal telomeres.

They discovered that TBK1 is modified by addition of phosphate groups during mitosis and TBK1 localizes to regions of the cell called centrosomes that regulate chromosomal separation.

When imposing repair on broken DNA strands during mitosis, some telomeres are seen to fuse together (one dot).

«A way to stabilize haploidy in animal cells: Mammalian haploid cells present problems during mitosis that limit their viability; the removal of the p53 tumor suppressor gene increases the survival rate of these cells thereby stabilising their haploid state.»

During the mitosis stage of budding yeast's division, aggregates of abnormal protein are tethered to well - anchored mitochondria in the mother cell.

In roughly one - quarter of dividing human cells observed by Tomomi Kiyomitsu, a postdoctoral researcher in Whitehead Institute Member Iain Cheeseman's lab, the spindle was misaligned during mitosis, even after the paired chromosomes were pulled to opposite sides of the cell in late anaphase.

Telomeres are now shown to have a role in chromosome separation during mitosis.

In humans, aneuploidy is well known to be deleterious, causing genetic disorders such as Down syndrome (trisomy 21), and frequently occurring during mitosis in the genesis of cancer.

The reason for the rapid development of resistance was that these fungicides were single site inhibitors of fungal microtubule assembly during mitosis, via tubulin - benzimidazole - interactions.

Asymmetries can form as cells polarize, or can occur within cells, for instance during mitosis.

Remarkably, individual chromosomes remain separate entities during mitosis, whereas many other polymeric assemblies fuse with each other upon contact in a liquid - like manner.

The main focus of our research is to understand the regulation of gene expression by cohesin and related proteins, which are also required for sister chromatid cohesion during mitosis (see «Background»).

Until now, however, none has actually seen how human cells manage to divide into two equally - sized daughter cells during mitosis.

Finally, as we and others have shown, errors in chromosome segregation during mitosis have dramatic secondary consequences on genome integrity, including translocations, deletions and chromosome shattering (chromothripsis).

It contributes to spindle assembly and orientation during mitosis and to ciliogenesis in interphase.

We found that the interaction between two classic factors, condensin and TBP, plays a pivotal role in 3D chromosome organization, and ensures that a critical set of genes, the actively transcribed housekeeping genes, are accurately segregated during mitosis (Figure B and C).

It participates in the assembly of a bipolar spindle that ensures accurate segregation of chromosomes during mitosis.

During mitosis, microtubules disassemble and reform into spindles that are used by the dividing cell to move chromosomes.

Their studies show that the problem arises when the haploid cells try to separate their chromosomes during mitosis.

Heritable genetic variation is the result of genome instability during germ cell development, instability that arises through mutation, chromosome rearrangement or chromosome mis - segregation during mitosis or meiosis.

Until now, however, none has actually seen how cells manage to divide precisely into two equally - sized daughter cells during mitosis.

During mitosis, they contribute to the formation and orientation of the mitotic spindle.

Present at highest level in G2 phase and during mitosis (at protein level).

Splitting of centriole pairs in primary cells leads to multipolar spindles and causes mis - segregation of chromosomes during mitosis (aneuploidy).