Sentences with phrase «during normal aging»

Kidney failure, heart disease, arthritis, dental disease, cancer and cognitive dysfunction can occur during the normal aging process.

«Low - Calorie Diet Slows Aging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdings.

We will also determine whether the release of hormones from dense - core vesicles declines during normal aging and during the progression of neurodegenerative diseases, and thus could be a contributing factor to the age - related decline in neuronal function.

Cells with similar characteristics accumulate during normal aging as well as in younger persons infected with human immunodeficiency virus, suggesting that the process of replicative senescence is not an artifact of cell culture but is also occurring in vivo.

The researchers now want to find out exactly how Tregs interact with fat tissue and whether the immune cells accumulate in other organs during normal aging.

It is unclear how the entire body is affected because Spector looked only at telomeres, nucleotides on the ends of chromosomes that slowly erode as cells copy themselves during normal aging.

The brain changes its appearance during normal ageing as its cavities enlarge and its weight decreases.

Not exact matches

Whom it may benefit: This strategy works best for couples with normal to high life expectancies with similar earnings, who are planning to work until age 70 or have sufficient savings to provide any needed income during the deferral period.

Nearly 17 % of children who are of preschool age or younger are reported as being cared for by their father during normal business hours.

During one particularly tough period, I wrote an intensity - driven post called The F-ing Fours, with images of my child's (normal, age - appropriate) aggression freshly in my mind.

This invaluable resource will help you: - sleep better tonight in under ten minutes with the Quick Start guide - and sleep safer every night with the Safe Sleep Seven - sort out the fact and fiction of bedsharing and SIDS - learn about normal sleep at every age and stage, from newborn to new parent - direct your baby toward longer sleep when he's ready - tailor your approach to your baby's temperament - uncover the hidden costs of sleep training and «controlled crying» techniques - navigate naps at home and during daycare - handle criticism from family, friends, and health professionals - enjoy stories and tips from mothers like you - make the soundest sleep decisions for your family and your life

These are completely normal and reasonable physiological characteristics of this age: during the shallow sleep the brain is actively developing, information obtained during his waking time is being processed and analyzed; the body is storing energy and strength for the next day.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

«When we hear a sound, the normal aging brain keeps the sound in check during processing, but those with MCI have lost this inhibition and it was as if the flood gates were open since their neural response to the same sounds were over-exaggerated,» says Dr. Gavin Bidelman, first author on the study, a former RRI post-doctoral fellow and assistant professor at the University of Memphis.

But some of the babies did not show this normal decrease in vagal tone during distressing periods; the researchers found that these infants who lacked an effective response at ages three and six months shared a particular variant of the DRD2 gene, which regulates receptors for the neurotransmitter dopamine.

In addition to muscular dystrophy treatment research, similar studies might also be conducted in the future on loss of muscle strength during normal or accelerated aging.

The study involved 134 college students in Pittsburgh aged 18 to 24 who were given hand - held devices that allowed them to document their exposure to pro-smoking media messages during their normal routine over a three - week period.

To understand the link between aging and neurodegenerative disorders such as Alzheimer's disease, NIH scientists compared the genetic clocks that tick during the lives of normal and mutant flies.

A woman being obese (BMI of 30.0 or higher) prior to getting pregnant increased the odds of her child being overweight at age 2 by more than two-fold compared to women who had a normal pre-pregnancy weight (BMI between 18.5 and 25), after adjusting for weight gain during pregnancy, gestational diabetes and breastfeeding.

Exposure to ozone during childhood can also impair normal lung growth and development and may contribute to new asthma, which can start at any age.

For the first time, the scientists could quantitate two major trajectories of lung function leading to COPD: the fast decline trajectory, where lung function declines very rapidly from a normal level, and the alternative trajectory where suboptimal development of lung function during childhood and adolescence is the major determinant of COPD in older age.

Next, Abadir and colleagues compared the effects of different concentrations of losartan and valsartan on young diabetic and aged mice during the proliferation / remodeling phase of wound healing, which involves the regrowth of normal tissue.

Whether normal variations between people in the sleep - wake cycle during mid-life and during aging actually predispose or even protect against brain diseases such as AD is not clear.

(21) Moreover, while the link between excessive visceral adipose tissue and age - independent diabetes and metabolic syndrome widely known, recent studies suggest instead that it is the accumulation of senescent subcutaneous adipocyte progenitors — and their abnormal metabolic function — that drives similar diabetes - like phenotypes during the «normal» aging process.

Determination of transporter distributions and densities around select synapses in normal adult brains and how these parameters change during development, ageing, drug use and disease

Our global aim is to characterize the molecular pathways that regulate the behaviour of normal stem cells during homeostasis, and how they become deregulated during carcinogenesis and ageing.

These mechanisms are studied in normal and pathological conditions, and during ontogenetic development and ageing.

p53 not only down regulates cell division during the normal process of aging and senescence, but it is also involved in a response to DNA damage [27,28] and telomere shortening [29].

MCTs are thus a good choice for anyone who has increased energy needs, as following major surgery, during normal or stunted growth, to enhance athletic performance, and to counteract the decreased energy production that results from aging.

Twenty - five healthy, weight stable males and females aged 18 - 35 years were randomized to diets containing 5 % energy from protein (low protein), 15 % (normal protein), or 25 % (high protein), which they were overfed during the last 8 weeks of their 10 - 12 week stay in the in - patient unit.

During a normal work day, my boss (the CEO, age 45 +) and I typically wear jeans and a sweater or T - shirt, as we only have phone / email contact with clients.

Healthy aging cats should have normal findings during their veterinary exams, which should include listening for heart murmurs and blood pressure measurements.

During normal development, a puppy's eyes are enveloped by a membrane which stretches and breaks away by 8 weeks of age.

It's normal to have to get up during the night for a potty break with many puppies until 12 weeks of age or so, sometimes longer.

During a diagnosis of IE, a veterinary specialist will consider the animal's age, and conduct normal physical and neurological examinations along with standard blood work.

In general veterinarians recommend that a urinalysis is done during the normal annual health exam from age 7 on.

Senior cats and dogs, 7 years of age and older are eligible to receive this labwork at 50 % of the normal fee during an annual, geriatric or wellness examination, a savings of $ 86.15.

The easiest time to integrate dogs and cats is during their «socialisation period» (up to eight weeks of age in cats and 12 weeks in dogs), during which time puppies and kittens will accept the presence of the other individual as normal.

The disease has late - onset clinical signs and the dog is clinically normal during breeding age so genetic testing provides an important tool to avoid breeding dogs at risk of Lafora.

The following explanatory variables were included in the analysis: gender, breed, age of arrival to a new home (in weeks), place of birth (at mother's home / at breeder) amount of socialisation, number of children in the household, number of adults, number of dogs in the household, number of other diagnosed diseases, the time the dog has to spend alone during a normal day, amount of daily exercise, amount of activities done with the dog, dietary supplements, neutering status and type of food.

A covariate was included in the multivariate analyses if theoretical or empirical evidence supported its role as a risk factor for obesity, if it was a significant predictor of obesity in univariate regression models, or if including it in the full multivariate model led to a 5 % or greater change in the OR.48 Model 1 includes maternal IPV exposure, race / ethnicity (black, white, Hispanic, other / unknown), child sex (male, female), maternal age (20 - 25, 26 - 28, 29 - 33, 34 - 50 years), maternal education (less than high school, high school graduation, beyond high school), maternal nativity (US born, yes or no), child age in months, relationship with father (yes or no), maternal smoking during pregnancy (yes or no), maternal depression (as measured by a CIDI - SF cutoff score ≥ 0.5), maternal BMI (normal / underweight, overweight, obese), low birth weight (< 2500 g, ≥ 2500 g), whether the child takes a bottle to bed at age 3 years (yes or no), and average hours of child television viewing per day at age 3 years (< 2 h / d, ≥ 2 h / d).

It is not surprising, therefore, that in this study of offspring of women with normal glucose tolerance during pregnancy there was little association between maternal glucose concentrations and anthropometric measurements at age 2 years.

These findings are not unexpected given that study results for young offspring whose mothers had diabetes during pregnancy were indistinguishable from those for normal offspring at this age.