Sentences with phrase «during stem cell development»

Lin's team previously found that ATF6 is naturally «on» during stem cell development.

Not exact matches

Embryonic stem cells are produced during development by the same process of epigenetic programming that later will produce adult cells such as skin and brain.

Experiments in animal cells have shown that although these genes are required to form pluripotent stem cells during development, they are not powerful enough on their own to overcome the epigenetic programming of a mature cell and convert it to a pluripotent stem cell directly.

The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.

«During the development of specialized tissues from stem cells, enzymes belonging to the Tet family also oxidize the thymidine base, as we have now shown with the aid of highly sensitive analytical methods based on mass spectrometry.

During one - third of the year, the students will learn about the cutting - edge developments in the life sciences with the greatest entrepreneurial potential — from bioinformatics to neuroscience, epidemiology, drug discovery, and stem cell research.

The case presented in the latest paper, published in the journal Stem Cell Reports, suggests that uneven growth of identical twins could start during the early stages of preimplantation development.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

During embryonic development, undifferentiated stem cells accumulate methyl groups and other epigenetic marks that funnel them into one of the three germ layers, each of which gives rise to a different set of adult tissues.

This suggests that random errors occurring during DNA replication in normal stem cells are a major contributing factor in cancer development.

During embryonic development of mice, however, the situation is different: To build up the system, all mature blood and immune cells develop much more rapidly and almost completely from stem cells.

«We also think this method could be applied towards the development of culture conditions during differentiation of human stem cells.

McCain would ban scientists from using donor eggs to create disease - specific stem cell lines or chimeric animals to see how human stem cells behave during development.

All stem cells are immature cells known for their ability to multiply indefinitely and give rise to progenitor cells that mature into specific cell types that populate the body's tissues during embryonic development.

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal.

Dolmetsch exposes these stem cells to a variety of different growth factors that mimic those that induce stem cells to become neurons during normal development.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

«Molecular time signalling controls stem cells during brain's development.»

One possibility is that it's just random events during development, that as a few neural stem cells in a fetus give rise to a hundred billion nerve cells in an adult human brain, a lot of stuff happens.

Apart from advancing our understanding of how plants regulate their growth and shape, this research presents new questions for stem cell researchers in regards to cell size checkpoints and their importance during organism development.

Wnt signals play a key role in directing stem cells during embryonic development, which led Geiger and colleagues to hypothesize that it might be helping to control stem cell growth and pluripotency in the gut later in life.

All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.

This discovery by the scientists at the CRG provides an insight into stem cell - forming molecular mechanisms, and is therefore of great interest for studies on the early stages of life, during embryonic development.

During the initial stages of typical brain development, stem cells go through a period in which they divide to make more stem cells, increasing their numbers.

During brain development, these stem cells migrate outward from the center region.

Using genome analysis tools, scientists outlined the multistage process that sperm stem cells undergo during their normal development.

Instead of mimicking the complex 3D organization of the developing pituitary gland, this approach relies on the precisely timed exposure of human pluripotent stem cells to a few specific cellular signals that are known to play an important role during embryonic development.

But the identity of the progenitor, or stem cells, that give rise to Merkel cells during embryonic development and adulthood is unclear.

Also, because autism results from errors during development, it is unlikely that the stem cells can reverse those effects.

During embryonic development, organ - specific cell types are formed from pluripotent stem cells, which can differentiate into all cell types of the human body.

The ability of a fertilized egg to generate both embryonic and extra-embryonic tissues is referred to as «totipotency,» an ultimate stem cell state seen only during the earliest stages of embryonic development.

«For a stem cell therapy for Duchenne to move forward, we must have a better understanding of the cells we are generating from human pluripotent stem cells compared to the muscle stem cells found naturally in the human body and during the development process.»

They are produced during development from stem cells called glial progenitors.

Mammary stem cells can give rise to new breast cells during fetal development, adolescence or lactation and may also play a role in breast cancer, so they represent a highly promising avenue for breast cancer research.

Retrotransposons are normally silenced to prevent harmful mutations from occurring in egg and sperm cells, but are mobilized during certain stages of brain development, when neurons are being produced from dividing stem cells.

Neural crest cells are a type of stem cell; during vertebrate embryonic development, they eventually differentiate into specialized cells such as those that make facial skeleton cells or those that create pigment cells.

This migration may happen because the repair pathways initiated by the damaged cells are similar to pathways triggered during embryonic development, where stem cells are key, explains ReNeuron co-founder and chief scientific officer John Sinden.

Through this technology, scientists obtained stem cells from individuals with a genetic abnormality that confers increased susceptibility to schizophrenia, and they observed deficits during nerve development that could be traced to a specific gene called CYFIP1, which helps maintain a nerve cell's structure.

The researchers suggest that since the adult muscle stem cells are only activated when injury occurs (by trauma or exercise), they use a new set of genes from those used during embryonic development, which proceeds without injury.

With our unique robotic microscope technology, can we identify the major determinants of cell fate during normal development of stem cells and in neurodegenerative disease?

In parallel, the roles of symmetric and asymmetric cell divisions are investigated as a mechanism for governing stem cell self - renewal and differentiation during embryonic development and in the adult.

The findings from this one cell line are also inconsistent with clinical data from preimplantation genetic diagnosis, further suggesting that the stem cell assay may not wholly reflect what happens during human development.

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«This is precisely the kind of damage we would expect to see from something that was destroying neural and retinal stem cells during development,» said Arnold Kriegstein, MD, PhD, who directs the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at Ustem cells during development,» said Arnold Kriegstein, MD, PhD, who directs the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UStem Cell Research at UCSF.

The grand architecture of the human cortex, with its hundreds of distinct cell types, begins as a uniform layer of neural stem cells and builds itself from the inside out during several months of embryonic development.

Origins of Muscle Stem Cells: During development, the embryo has three different tissue types that, together with the germ cells, will make up the animal's entire Cells: During development, the embryo has three different tissue types that, together with the germ cells, will make up the animal's entire cells, will make up the animal's entire body.

Its pivotal role during development makes runx1 also a good candidate to play an important role in adult stem cells.

Canonical Wnt signaling promotes the proliferation and neurogenesis of peripheral olfactory stem cells during postnatal development and adult regeneration.

Using Drosophila as a model organism, his aims are to identify the gene regulatory networks that modulate neural stem cell properties during the course of development.

A switch has been discovered that instructs blood vessel cells to become blood stem cells during embryonic development in mice.