The tri-dimensional organization of the genome is clearly linked to its function as it
varies during the cell cycle and upon differentiation in metazoan.
Figure 1: Live - cell imaging of Ki - 67 (green)
during the cell cycle reveals its re-localisation from nucleoli to the surface of mitotic chromosomes (magenta).
And while this feat should already be enough to warrant devoting a whole blog post to cohesin, you will shortly realize that this complex also performs a myriad of other
functions during the cell cycle, which really makes it «one ring to rule them all».
For example, data may fluctuate depending on cell type, timing of data collection (
during the cell cycle, or diurnal, seasonal, or annual variations), developmental stage, and various external conditions.