Sentences with phrase «during the recent years there»

In the case of imprinted genes, the context of crucial importance is the parental ancestry of those variants, and during the recent years there has been increasing emphasis on our need to understand how imprinting modifies genetic associations to disease.

During the recent years there is a growing shift of emphasis from task — oriented and functional requirements to non-functional, experiential and hedonic aspects of interaction.

Not exact matches

There were $ 221 billion worth of pharmaceutical deals completed in the first half of this year, triple the amount during the first half of 2014, according to a recent report from consulting firm KPMG.

The IPO market has swung back and forth since the dot - com boom in the late 1990s through the bust a few years later and on up to the most recent economic downturn, during which there were six venture capital - backed IPOs in 2008 and 12 in 2009 — compared with 86 in 2007, according to the Exit Poll report by Thomson Reuters and the National Venture Capital Association.

Some of the provinces and companies have built up debt in recent years during the recovery, since there has been so very much artificial liquidity all over the world.

Volume has been low during the recent price decline and one would expect it to remain there as Chinese New Year approaches.

Though, when you take a closer look at recent equity performance in May, each year there has been some volatility in the markets during May and the overall gains have been only marginal.

Christians, like many others, suffered severely during the Cultural Revolution, but in recent years there has been quite a rapid growth in numbers of both Catholics and Protestants.

There is no doubt in my mind that the most disastrous decision we made during the past calendar year, up to and including the most eventful January transfer window in recent memory, was not the Sanchez debacle that saw him off to Old Trafford, which will forever be considered a failure of epic proportions, or the selling off of Ox to Liverpool following a thrashing less than a fortnight earlier, or even the triangular clusterf * ck that saw Giroud head to our crosstown rivals in the 11th hour, but the re-upping of our manager after another tumultuous and cringe - worthy campaign both on and off the pitch.

In addition to honest and open communication concerns, there are also fundamental issues of managerial incompetence, poor negotiating strategy, procrastination, dithering, lack of ambition, lack of willingness to compete with the top teams in the league despite supposedly being financial heavyweights, desperation at the very end of the window, compounded by promises made when Arsene was re-signed and poor team selection decisions for the first three matches, further compounded by a pattern of incompetence during transfer windows and in general management of the team in recent years that understandable has fan patience at a very low level.

I definitely do not count myself among the Arsenal fans who have been calling for a change at the top in recent years, but there have been times when I have despaired at what looks like stubbornness from Wenger, at best, and naivety or downright failure at worst, usually during a transfer window.

There had been talk in recent weeks that Arsenal youngster Jeff Reine - Adelaide was in line for a call up to the first team, due to his fantastic performances with Arsenal during pre-season, as well as his game time with the Under 21's last year.

While the Germany international star, who Arsene Wenger smashed the Arsenal transfer record to sign from Real Madrid a few years ago, was one of a number of high profile Gunners to enter the final year of their current contracts during the recent summer transfer window, there was far less talk and far fewer Arsenal transfer rumours about Mesut Ozil than there were about our Chilean striker Alexis Sanchez and the new Liverpool player Alex Oxlade - Chamberlain.

Picture this, we don't come out of the gate firing on all cylinders, Wenger speaks of how there wasn't enough time for the first - teamers to build chemistry, several key players aren't even playing because of Wenger's utterly ridiculous policy regarding players who played in the Confed Cup or the under21s and the boo - birds have returned in full flight... if these things were to happen, which is quite possible considering the Groundhog Day mentality of this club, how long do you think it will take for Wenger to recant his earlier statements regarding Europa... I would suggest that it's these sorts of comments from Wenger which are often his undoing... why would any manager worth his weight in salt make such a definitive statement before the season has even started... why would any manager who fashions himself an educated man make such pronouncements before even knowing what his starting 11 will be come Friday, let alone on September 1st... why would any manager who has a tenuous relationship with a great many supporters offer up such a potentially contentious talking point considering how many times his own words have come back to bite him in the ass... I think he does this because he doesn't care what you or I think, in fact he's more than slightly infuriated by the very idea of having to answer to the likes of you and me... that might have been acceptable during his formative years in charge, when the fans were rewarded with an scintillating brand of football and success felt like a forgone conclusion, but this new Wenger led team barely resembles that team of ore... whereas in times past we relished a few words from our seemingly cerebral manager, in recent times those words have been replaced by a myriad of excuses, a plethora of infuriating stories about who he could have signed but didn't and what can only be construed as outright fabrications... it's kind of funny that when we want some answers, like during the whole contract debacle of last season, we can't get an intelligent word out of him, but when we just what him to show his managerial acumen through his actions, we can't seem to get him to shut - up... I beg you to prove me wrong Arsene

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

There has been a lot of rivalry between United and Manchester City in recent years but during the Second World War, the latter came to help out by lending their Maine Road ground when Old Trafford was rendered unplayable owing to bomb damage.

The hard - man culture reached its peak during the 1970's and early 1980's although there were still pockets until recent years, when football became much less of a contact sport.

However, there was no significant evidence of an association between early postnatal life (during the first year of life), recent and current exposures to outdoor air pollutants with lung function at preschool age.

From the heavy rains that sent the Seine into the streets of Paris last year to a parade of storms that left southern England waterlogged during the winter of 2013 - 2014, there have been startling examples in recent years of the heavy toll that flooding can levy in both human and economic terms.

«This is the first - ever such survey in the Northwest Passage, and we were surprised to find this much thick ice in the region in late winter, despite the fact that there is more and more open water in recent years during late summer,» says Haas.

Their research shows that during the past 32 years there have been widespread increases in both plant growth and evaporation due to recent global climate trends.

Film Review by Kam Williams Headline: Streep and Hoffman Square - Off in Screen Adaptation of Modern Parable There has been an explosion of lawsuits filed against the Catholic Church in recent years by parishioners claiming to have been molested and left traumatized by pedophile priests during childhood.

The premise is that there would be a cumulative effect of principal turnover during this time, which would appear as an overall low level of achievement in the schools in the most recent three years.

During the most recent school year, there have been over three million enrollments in Apex Learning Comprehensive Courses and Adaptive Tutorials.

There have been many anecdotal testimonials describing the benefits of Radio - wave Surgery over the past 25 years, during which it has been a mainstay in veterinary medical hospitals, especially those that treat avian and exotic species.2 Recent advances, however, require us to revisit this technology and consider a broader application to other veterinary species.

It's fair to say that not many journalists know more about what life is like in Iraq more than Paulien Bakker, who has traveled to the country 15 times during the last few years to cover the country's recent tumultuous past, as well as to document the everyday lives of the Iraqis living there.

There's no better time to visit and get a taste of the current landscape than during the Triennial: This year's is co-curated by artist Ryan Trecartin and curator Lauren Cornell, gathering recent works from artists around the world that explore today's hyper - connected media culture.

During the cataclysmic upheavals painting has undergone in recent years there have been rather drastic measures taken with the object.

During his year there, he completed a series of paintings that while predicated on structures already emerging in his recent work address the extended history of geometric imagery that he set out to explore in his Rome project, «New Paintings for -LSB-...]

During his year there, he completed a series of paintings that while predicated on structures already emerging in his recent work address the extended history of geometric imagery that he set out to explore in his Rome project, «New Paintings for an Old City.»

Although non-representative art became more and more popular during the 20th century, there has been a renewed interest in the Pre-Raphaelites in recent years.

Such results do not show the long - term trends, but it's a fact that there have been high temperatures in the Arctic during the recent years.

During recent years (1993 — 2003), for which the observing system is much better, thermal expansion and melting of land ice each account for about half of the observed sea level rise, although there is some uncertainty in the estimates.

B. Over the same time interval there have been periods during which the reported «Annual Temperature of the Earth (TOE)» has increased, others during which it decreased, and yet others, like the most recent 15 - 20 years over which it has remained statistically flat.

But during the last 7000 years there have been greater fluctuations in temperature without the intervention of man, and there seems to be no reason to regard the recent rise as more than a coincidence.

there has been no statistically discernible rise in global temperature for the most recent 15 years despite atmospheric CO2 concentration rising by ~ 4 % during that time so the rise in the CO2 is observed to not be overwhelming other causes of the temperature change, 2.

In addition to that the lacking warming during the recent 15 years can not be explained by any change of CO2 content in the atmosphere, there are evidences available according to which the changes of CO2 contents in the atmosphere are dominated by natural causes, where influence of anthropogenic CO2 emissions is so minimal that it can not be found by measurements in reality.

For instance, ground source heat pumps tend to have higher efficiencies than air source units during the heating season due to the relative stability of ground temperatures below certain depths, though air source units — which involve much lower capital costs — have closed the gap in recent years as manufacturers have refined their design, and there is evidence to indicate that space heating demand in many Irish buildings may be peaking in Ireland's frequently relatively mild but windy weather, as the guide to air source heat pumps in Issue 24 of Passive House Plus discussed.

Monaghan et al. further note «recent literature suggests there has been little overall change in Antarctic near - surface temperature during the past 5 decades» and «the absence of widespread Antarctic temperature increases is consistent with studies showing little overall change in other Antarctic climate indicators during the past 50 years such as sea ice area and snowfall.»

The current warming trend 1998 - 2005, has no precedent in recent Arctic memory, there were a few unique occasions when open water was seen during mid-winter over Barrow Strait, but this was at roughly 10 year intervals, now the intervals are totally irregular, but between Islands ice cover is not the best indication of warming, monthly temperature readings for the past 4 years or so, have been mostly above normal by 1 to the occasional 4 to 5 degrees.

There is simply no precendent during my nearly seventy years for how scientists have been pushed around in recent years.

During a recent conference, Deutsche Bank president Marcus Schenck revealed that there is a hypothesis that traditional bank accounts may be phased out over the next 20 years, to be replaced by digital wallets.

The company admitted during its CES reveal that there have been a few missteps in recent years, focusing on products that became a distraction more than a boon to the brand.

If you have been on any number of interviews in recent years, you know there are some standard questions that are asked during an interview.

However, during recent years, it has been shown that there is a great variability in the way the marital relations change during transition to parenthood (Bradbury et al., 2000).

Because of the many foreclosures during recent years, there are scores of houses in many neighborhoods that need refurbishing.