Sentences with phrase «during the replication of»

A research group from the University of Seville has revealed the role that the protein Rrm3 plays in the repair of breaks that occur during the replication of DNA, by using the yeast Saccharomyces cerevisiae as a model organism.

It corrects mutations that arise during the replication of the genome during cell division.

These tests detect a protein produced during replication of the FeLV virus which is usually present in the blood of cats persistently infected with the virus.

A sheepish post on the game's official forum states, «Unfortunately a defect occurred during replication of the PC version of Terminator Salvation, which does not allow end users to install the game.

Not exact matches

It was inexplicable during hgp was why there was so much of this stuff, when all it could contribute was error in replication and recombination.

This book covers: - The need to advance exclusive breastfeeding - Obstacles and opportunities for exclusive breastfeeding during the reproductive health continuum - Findings related to the obstacles, opportunities, current interventions, and gaps at eight time periods during the reproductive health cycle - Suggestions for innovative implementation to advance exclusive breastfeeding - The Surgeon General's Call to Action to Support Breastfeeding - Monitoring, evaluation, and research needs - Considerations for expansion, replication, and scaling up of activities - Next steps

Telomeres are repetitive stretches of DNA that cap natural chromosome ends to protect them from being damaged or fused together during DNA replication.

Telomeres provide protection to chromosomes during the replication process to prevent the loss of DNA strands.

Genes encoding ribosomal proteins, DNA replication and repair machinery, oxidative stress, and purine biosynthesis were differentially expressed in Wolbachia during the development of B. malayi female worms, suggesting a role of the bacteria in worm reproduction.

This group also clarified that Shugoshin controls DNA replication (the process by which DNA makes a copy of itself during cell division) in subtelomeres as well as higher - order structure of chromosomes.

This is because during replication, DNA polymerase can only synthesize DNA in a 5 «to 3 «direction and can only do so by adding polynucleotides to an RNA primer that has already been placed at various points along the length of the DNA.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

It has multiple hosts and can evolve by mutation but also reassortment (when two closely related strains infect the same host and exchange gene segments, producing new strains — a process distinct from mutation, when the RNA of a virus is miscoded during replication).

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

The dance of chromosomes is tightly controlled during cell replication to preserve the genetic makeup of cells.

Previous research had shown that Topisomerase II was involved in earlier cellular processes like DNA replication, and the enzyme was still detectable even during later phases of meiosis.

The PR - 2B DENV - 2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication.

Fishel and Kolodner had been studying the bacteria and yeast genes involved in the repair process that operates when base pairs slip out of alignment during replication, producing mismatches of bases.

During meiosis, the genome of a diploid germ cell, which is composed of long segments of DNA packaged into chromosomes, undergoes DNA replication followed by two rounds of division, resulting in haploid cells called gametes.

The shortening of telomeres is a process that occurs naturally in the body each time that a cell divides: during cell division the DNA, which is tightly packaged into chromosomes, must be duplicated but the DNA - copying machinery design itself, prevents the full replication of the ends of the chromosomes.

During this stage, the replication forks can meet obstacles that cause their blockage or even the appearance of breaks in the DNA.

«The role of the protein Rrm3 in the repair of breaks in DNA during replication.»

In a September paper in the Journal of Chemical Physics, he reported the theoretical minimum amount of dissipation that can occur during the self - replication of RNA molecules and bacterial cells, and showed that it is very close to the actual amounts these systems dissipate when replicating.

Telomeres are repetitive nucleotide sequences found at the end of chromosomes which protect them from deteriorating during the process of replication.

The mergers occur during DNA replication, when matching segments of otherwise disparate genes mistakenly pair up.

Holstege says the other remarkable finding was that the mutations within the blood cells were harmless — all resulted from mistaken replication of DNA during van Andel - Schipper's life as the «mother» blood stem cells multiplied to provide clones from which blood was repeatedly replenished.

Tanaka had sequenced the middle region of the code for NS5B, the enzyme that makes new genome copies during replication.

An efficient unfolding of these structures is necessary in order to secure the integrity of the genome during DNA replication,» says Nasim Sabouri.

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body's repair mechanism.

Based on the nucleotide context, the authors suggest that a new mutational mechanism may be at work involving cytosine deamination of single - stranded DNA (presumably during replication).

Mechanistically, the instability of CEB1 occurs during leading - strand replication.

That's a lot of T's, C's, G's, and A's, and sometimes mistakes happen during replication.

April 17, 2018 - During any viral infection our immune system produces a powerful molecule (Interferon), which «interferes» with the infection and the replication of viruses.

For instance, classical and alternative pathways interplay and compete for the repair of DSBs occurring during replication (i.e. damaged replication forks)(Figure 1B).

They discovered that this region is prone to errors during DNA replication, resulting in expansion of the polyglutamine tract.

DNA is constantly exposed to a variety of damaging factors such as genotoxic agents, environmental factors (e.g. UV light, irradiation) or normal metabolic activities (e.g. nucleotide misincorporation during DNA replication, reactive oxygen species) that causes a range of lesions.

Somatic Cell Mutants Resistant to Retrovirus Replication: Intracellular Blocks during the Early Stages of Infection

That poses an obvious problem during S phase: While DNA replication machineries («replisomes») zip along the chromosomes trying to faithfully duplicate the entire genome in a matter of just a couple of hours, they encounter — on average — multiple cohesin rings that are already wrapped around DNA.

Moreover, given that point mutations are acquired through DNA copy - errors (and / or failure of DNA damage repair mechanisms) during replication, preferentially within the paternal germline, a detailed knowledge of these basic biological processes is key to understanding the patterns of nucleotide substitutions.

We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication to gain insights into virus - host interactions, using conditional Burkitt lymphoma models of type I and II EBV infection.

Some bacteria have a loop of DNA, and two interlocking rings of nucleic acid can appear as an intermediate during cell replication.

During the DNA replication process, telomeres keep the DNA together (like how the plastic caps on the end of shoelaces keep them from unraveling).

Because of these nearly ubiquitous toxic exposures, however, over the past decades many babies have been born with genes scarred from exposure to inflammatory chemicals during key periods of replication.

During his PhD under the supervision of Drs. Luis Enjuanes and Fernando Almazan at the National Centre of Biotecnology (Madrid, Spain), he studied the mechanism of replication and transcription of coronavirus and the role of host factors that modulate these processes.

The CDC also indicated that during the summer 2012 ``... outbreak likely resulted from many factors, including higher - than - normal temperatures that influenced mosquito and bird abundance, the replication of the virus in its host mosquitoes, and interactions of birds and mosquitoes in hard - hit areas.»

Fritz Schweingruber was aware that the replication of the original Polar Urals chronology was quite low during medieval times and asked for further samples (see page 4 of our SM4 document), which turned out to be non-ideal, as we've demonstrated by comparison with other trees but which might have been expected because they are from the root collar.

The lessons learned are critically analysed, and the opportunities for replication and scaling - up, and for filling in some of the gaps during follow - up interventions, explored.

The National Comorbidity Study Replication, for example, found that during a 12 month period - and among those receiving treatment for mental health concerns - the median number of clinic visits was 2.9 (Wang et al., 2005).