Sentences with phrase «during tumor development»

As we improve methods to identify epigenetic changes that occur during tumor development, can we develop approaches to discriminate between «driver» and «passenger» epigenetic events?

The idea is that mutations driving cancer are positively selected for during tumor development, and so their frequencies should be higher than those of passenger mutations.

Emerging date has shown that IDO1 is induced during tumor development and / or after immune checkpoint treatment in multiple tumor types, helping malignant cells escape eradication by the immune system.

For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.

This model of dosage amplification during tumor development had not previously been considered,» says Sebastian Müller, lead author of the study.

16) Lockwood WW †, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Solis LM, Nunez MI, Behrens C, Yee J, English J, Murray N, Tsao MS, Minna J, Gazdar AF, Wistuba II, MacAulay CE, Lam S, Lam WL (2012) Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.

Study identifies cellular signaling pathway that enables breast cells to resist tissue changes during tumor development and is associated with better prognosis

We also unraveled the role of PHD2 in different cancer cells during tumor development in mice.

Emerging evidence suggests that IDO1 is induced during tumor development or after immune checkpoint treatment in multiple tumor types, helping malignant cells escape eradication by the immune system.

During tumor development, rapid expansion of cancer cells creates a hypoxic microenvironment that is followed by periods of reoxygenation to promote tumor progression.